Histopathological and Immunophenotypical Features of Intestinal-Type Adenocarcinoma of the Gallbladder and its Precursors

You, Yan; Bui, Katherine; Malafa, Mokenge P.; Coppola, Domenico

doi:10.1177/107327481402100312

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…Ann Jinnah Sindh Med Uni 2020; 6(1): [24][25][26][27][28] In our study, chronic cholecystitis with cholelithiasis is the most commonly encountered gall bladder disease which is in line with other studies done in Pakistan and neighbouring countries. 21,22 However, in developed countries, chronic cholecystitis is a common finding as compared to association with cholelithiasis.…”

Section: Discussionsupporting

confidence: 84%

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Morphological Spectrum of Gall Bladder Diseases at A Tertiary Care Hospital of Karachi

Shabbir¹,

Irshad²,

Javed³

et al. 2020

Ann Jinnah Sindh Med Uni

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Objectives: To determine morphological spectrum of gall bladder diseases at a tertiary care centre of Karachi and to correlate with age and gender. Methodology: Data was collected from histopathological records between June 2017 to June 2019. Relevant data including registration number, age, gender of the patients and diagnosis were recorded. Data was entered and analyzed using SPSS version 21. P-value < 0.05 was considered as significant. Results: In our study, patients 26-35 years of age were predominantly found to be susceptible to gall bladder diseases and male to female ratio was 1:3.7. Out of the total 150 cases, 75 were identified as chronic cholecystitis with cholelithiasis whereas 32 cases of chronic cholecystitis were without stones or any other associated pathology. Out of 150 cases, 40 were seen in combination with different pathologies. Our series also included three cases of adenocarcinoma and all of these were diagnosed in females. Significant association of diagnosis was seen with gender and type of stones (p-value = 0.03) (p-value = 0.01) respectively. Conclusion: In our study, chronic cholecystitis with cholelithiasis was the most common finding which was most predominantly seen in females. Younger age group was mainly affected in both genders. Mixed type of gall stones were the most common stones found in our series.

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Section: Discussionsupporting

confidence: 84%

“…DOI:https://doi.org/10.46663/ajsmu.v6i1. [24][25][26][27][28] Acute pancreatitis is the other severe complication of cholelithiasis. 11 Moreover, literature shows that gall bladder diseases are the major risk factor for developing hepatocellular carcinoma independent of cirrhosis and viral hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Morphological Spectrum of Gall Bladder Diseases at A Tertiary Care Hospital of Karachi

Shabbir¹,

Irshad²,

Javed³

et al. 2020

Ann Jinnah Sindh Med Uni

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“…Gallbladder adenoma itself exhibited no clinical symptoms, and the symptoms were mainly induced by cholecystitis, cholelith disease. About 1/3 to 3/5 of the gallbladder adenoma was accompanying with gallbladder stone [11][12][13]. The form of gallbladder adenoma was larger, multiple, and can cause a series of clinical symptoms [14].…”

Section: Discussionmentioning

confidence: 99%

Imaging diagnosis of gallbladder adenoma

Jian¹,

Zhu²,

Lv³

et al. 2018

biomedicalresearch

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Recent studies have shown that the gallbladder adenomas belong to precancerous lesions, with possible malignant transformation, and imaging examination is the first choice for the diagnosis. The study was involved in the diagnosis of gallbladder adenoma commonalities by ultrasound, CT and MRI in characterization of do retrospective analysis in order to improve the accuracy. 32 cases of hospitalized patients with the diagnosis of gallbladder adenoma were collected. The 32 patients were retrospectively analyzed by ultrasound, CT and MRI images to find its generality characteristic imaging. B ultrasonic echo showed that the diameter of the malignant papillary adenoma increased in 18 cases of cystic papillary adenoma; CT showed that adenoma internal density was uniform and CT values continue to rise; MRI in common displayed for contour shadow equally. The benign lesions were wide and the malignant lesions were narrow. Portal phase lesions around was continuous reinforced obviously and the central displayed slightly lower density area. In the 14 cases of gallbladder tubular papillary adenoma, ultrasound showed that medium echoes, and commonness CT in enhanced arterial phase, portal phase and delay lesions was progressively light-moderate strengthened. MRI was performed for single nodule "cauliflower" shaped surface and signal shadow, and high signal stove, borders, "cauliflower" shaped surface was tested on the malignant nodules. Imaging diagnostic methods can improve the detection rate of gallbladder adenoma and reduce missed diagnosis.

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“…The proportion of cells staining positive for each marker as a percentage of the total number of neoplastic cells was calculated. Immunostaining for p53 DO-7, Leica ; 800-fold dilution was also carried out following the same staining procedure [1][2][3] .…”

Section: Investigation Of Cell Lineagementioning

confidence: 99%

“…These elevated lesions form a diverse group that includes not only cholesterol polyps, hyperplastic polyps, and adenomyomatosis, but also adenomas and adenocarcinomas. Adenocarcinomas are further subdivided into low-grade tumors, which may be confused with adenomas and hyperplastic polyps, and obviously high-grade tumors [1][2][3] . The present study focused on the characteristics of the neoplastic cells in intraluminal elevated lesions in patients diagnosed with massforming gallbladder cancer, as well as the influence of the cellular dysplastic grade on the clinicopathological features, including staging and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Study of Mass-forming Gallbladder Cancer Focusing on the Grade of Cellular Dysplasia

:筆頭著者:責任著者

Ohike

Suzuki

et al. 2018

Showa Univ J Med Sci

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The relationship between the clinicopathological features and the grade of cellular dysplasia of the neoplastic glands in mass-forming gallbladder cancer was investigated. In this retrospective study, 41 mass-forming 1 cm gallbladder cancer specimens from 83 resected cases were examined. Tumors were classi ed into three groups : Group A had intraluminal masses consisting of neoplastic glands with only low-grade dysplasia ; Group B had mixed low-and high-grade dysplasia, and Group C had only high-grade dysplasia. Of the 41 tumors, 13 were classi ed as Group A, 11 as Group B, and 17 as Group C. For Group A, B, and C, respectively, the mean tumor diameter was 1.6, 3.7 and 3.4 cm ; macroscopic type pedunculated / semi-pedunculated / sessile was 7 / 5 / 1, 4 / 6 / 1 and 0 / 10 / 7 ; frequency of an invasive component inside the mass was 0 , 9 and 82 ; and cell lineage biliary / metaplastic / mixed was 2 / 1 / 10, 8 / 1 / 2 and 14 / 1 / 2. In addition, invasion depth Tis T1 / T2 / T3 was 13 / 0 / 0, 7 / 4 / 0 and 3 / 10 / 4 ; lymph node metastases were present in 0 , 9 and 24 of patients ; 3-year survival rate was 100 , 100 and 82 ; and 5-year survival rate was 100 , 100 and 69 , for A, B and C, respectively. Signi cant intergroup differences were seen for positive lymph node metastasis rate and 5-year survival rate. The present study indicates that the clinicopathological features of mass-forming gallbladder cancer are different depending on the grade of cellular dysplasia of the mass lesion. The tumors in Groups A and B were of lower malignancy than those in Group C and the prognosis of patients in the former groups was excellent. Group A and B tumors may be intracholecystic papillary-tubular neoplasms, a recently proposed new disease concept.

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Histopathological and Immunophenotypical Features of Intestinal-Type Adenocarcinoma of the Gallbladder and its Precursors

Abstract: This case showed the complete spectrum of the progression of intestinal-type intracholecystic papillary-tubular neoplasms of the gallbladder.

Cited by 6 publications

References 19 publications

Morphological Spectrum of Gall Bladder Diseases at A Tertiary Care Hospital of Karachi

Morphological Spectrum of Gall Bladder Diseases at A Tertiary Care Hospital of Karachi

Imaging diagnosis of gallbladder adenoma

Clinicopathological Study of Mass-forming Gallbladder Cancer Focusing on the Grade of Cellular Dysplasia

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