Histopathological and molecular links of COVID-19 with novel clinical manifestations for the management of coronavirus-like complications

Sood, Ankita; Bedi, Onkar

doi:10.1007/s10787-022-00999-9

Cited by 3 publications

(2 citation statements)

References 112 publications

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“…With the initiation and promotion of this inflammatory cascade, pathological events such as pulmonary damage, ARDS, sepsis, tissue damage, and multi-organ failure occur. Target organs include the lungs, kidney, heart, small intestine, pancreas, liver, and brain [2,6,7]. Pre-existing health conditions such as obesity, hypertension, diabetes, and lung disease may increase the disease burden of COVID-19 and increase morbidity [6].…”

Section: Introductionmentioning

confidence: 99%

The Optimal Strategies to Be Adopted in Controlling the Co-Circulation of COVID-19, Dengue and HIV: Insight from a Mathematical Model

Omame

Raezah

Diala

et al. 2023

Axioms

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The pandemic caused by COVID-19 led to serious disruptions in the preventive efforts against other infectious diseases. In this work, a robust mathematical co-dynamical model of COVID-19, dengue, and HIV is designed. Rigorous analyses for investigating the dynamical properties of the designed model are implemented. Under a special case, the stability of the model’s equilibria is demonstrated using well-known candidates for the Lyapunov function. To reduce the co-circulation of the three diseases, optimal interventions were defined for the model and the control system was analyzed. Simulations of the model showed different control scenarios, which could have a positive or detrimental impact on reducing the co-circulation of the diseases. Highlights of the simulations included: (i) Upon implementation of the first intervention strategy (control against COVID-19 and dengue), it was observed that a significant number of single and dual infection cases were averted. (ii) Under the COVID-19 and HIV prevention strategy, a remarkable number of new single and dual infection cases were also prevented. (iii) Under the COVID-19 and co-infection prevention strategy, a significant number of new infections were averted. (iv) Comparing all the intervention measures considered in this study, it is possible to state that the strategy that combined COVID-19/HIV averted the highest number of new infections. Thus, the COVID-19/HIV strategy would be the ideal and optimal strategy to adopt in controlling the co-spread of COVID-19, dengue, and HIV.

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Section: Introductionmentioning

confidence: 99%

The Optimal Strategies to Be Adopted in Controlling the Co-Circulation of COVID-19, Dengue and HIV: Insight from a Mathematical Model

Omame

Raezah

Diala

et al. 2023

Axioms

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show abstract

“…The 2019 coronavirus pandemic (COVID- 19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had devastating consequences on the mortality and morbidity of afflicted individuals worldwide. Although most patients presented asymptomatic or mild disease states, others developed severe disease, often associated with excessive inflammation and respiratory distress [1,2]. The innate immune system has the crucial role of recognizing the virus and activate inflammatory pathways in order to mount an effective antiviral response and viral clearance [3].…”

Section: Introductionmentioning

confidence: 99%

Obesity in Severe COVID-19 Patients Has a Distinct Innate Immune Phenotype

et al. 2023

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Obesity alters the capacity of effective immune responses in infections. To further address this phenomenon in the context of COVID-19, this study investigated how the immunophenotype of leukocytes was altered in individuals with obesity in severe COVID-19. This cross-sectional study enrolled 27 ICU COVID-19 patients (67% women, 56.33 ± 19.55 years) that were assigned to obese (BMI ≥ 30 kg/m2, n = 9) or non-obese (BMI < 30kg/m2, n = 18) groups. Monocytes, NK, and both Low-Density (LD) and High-Density (HD) neutrophils were isolated from peripheral blood samples, and surface receptors’ frequency and expression patterns were analyzed by flow cytometry. Clinical status and biochemical data were additionally evaluated. The frequency of monocytes was negatively correlated with BMI, while NK cells and HD neutrophils were positively associated (p < 0.05). Patients with obesity showed a significant reduction of monocytes, and these cells expressed high levels of PD-L1 (p < 0.05). A higher frequency of NK cells and increased expression of TREM-1+ on HD neutrophils were detected in obese patients (p < 0.05). The expression of receptors related to antigen-presentation, phagocytosis, chemotaxis, inflammation and suppression were strongly correlated with clinical markers only in obese patients (p < 0.05). Collectively, these outcomes revealed that obesity differentially affected, and largely depressed, innate immune response in severe COVID-19.

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Prevention of Scarring of Lung Parenchyma in COVID-19 Patients through Glucocorticoid Treatment

Nurgül

Yalcin

2023

am j health behav

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Objective: The objective of this research was to determine the impact of glucocorticoid treatment on preventing scarring of lung parenchyma in COVID-19 patients by considering their health behavior. Methods: A sample of 65 Turkish patients who had pneumonia and were hospitalized between March/December 2020 were included in this research. The data for this research was collected after the consent of the hospital. The structural equation model approach was used in data analysis and empirical findings. Results: The research identified that the patients with appropriate health behavior were satisfied with their clinical treatment of scarring of lung parenchyma by the method of glucocorticoid treatment. The research also identified that the patient's health behavior was a significant indicator to improve their perception of the clinical treatment. Conclusion: This study has reliable theoretical implications that are significantly important in the literature because of the nature and uniqueness of the findings. However, this research also has some practical implications related to the patient's lungs mostly infected by COVID-19. Furthermore, the findings of this research can be generalized in a significant way because the respondents of this research belonged to a diverse population.

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Histopathological and molecular links of COVID-19 with novel clinical manifestations for the management of coronavirus-like complications

Cited by 3 publications

References 112 publications

The Optimal Strategies to Be Adopted in Controlling the Co-Circulation of COVID-19, Dengue and HIV: Insight from a Mathematical Model

The Optimal Strategies to Be Adopted in Controlling the Co-Circulation of COVID-19, Dengue and HIV: Insight from a Mathematical Model

Obesity in Severe COVID-19 Patients Has a Distinct Innate Immune Phenotype

Prevention of Scarring of Lung Parenchyma in COVID-19 Patients through Glucocorticoid Treatment

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