Histopathological and Morphometric Study of Cochleosaccular Dysplasia in Dalmatian Dogs

Sampaio, André Luiz Lopes; Schachern, Patricia A.; Sutherland, Carolyn; Cüreoğlu, Sebahattin; Paine, Elizabeth; Paparella, Michael M.; Oliveira, Carlos Augusto de

doi:10.1016/j.otohns.2004.06.249

Cited by 3 publications

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“…Congenital sensorineural deafness is a common form of hereditary deafness, reported in more than 80 breeds of dogs at prevalence rates up to 30% in Dalmatians, 20% in white Bull Terriers and 14.6% in the Australian Cattle Dog (Strain 2004(Strain , 2020. This form of deafness arises in puppies in the first 4 weeks of life following cochleosaccular or neuroepithelial degeneration (Coppens et al 2000(Coppens et al , 2003Sampaio et al 2010) and deafness can occur in one (unilateral) or both (bilateral) ears. A genetic basis for this deafness is supported by the observation that greatly increased numbers of affected puppies are found in litters bred from parents with one or more deaf ears (Strain et al 1992) and lower in pups with four hearing grandparents than those with one or no grandparents that are tested hearing (Sommerlad et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome‐wide association study analyses

et al. 2021

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Summary Pigment‐associated deafness is a common hereditary condition in a range of dog breeds. The aim of this study was to perform a genome‐wide association analysis to investigate the genetic architecture of deafness in Australian Cattle Dogs. Genotypes for 104 757 polymorphisms in 216 dogs were available for analyses after quality control. A genomic relationship matrix was used in the mixed model analyses to account for polygenic effects, as we tested each polymorphism for its association with deafness, in a case/control experimental design. Three approaches were used to code the genotypes and test for additive, recessive and dominant SNP effects. The genome‐wide association study analyses identified a clear association peak on CFA20, with the most significant SNPs on this chromosome (1.29 × 10−4) in the vicinity of MITF. Variants in MITF have been associated with white pigmentation in dogs and with deafness in humans and other species, supporting the premise that canine deafness is associated with variants in or near this gene. A recessive inheritance for the peak in CFA20 is possible given the significant results in the recessive model; however, the estimated heritability was low (4.54 × 10−5). Further validation, identification of variants and testing in other dog breeds are needed.

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Section: Introductionmentioning

confidence: 99%

Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome‐wide association study analyses

et al. 2021

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“…Cochlea‐related histopathological changes, such as congenital sensorineural deafness in paint horses, are possibly caused by cochleosaccular dysplasia (Wilson et al., ‬). The latter is also responsible for inherited deafness due to a lack of facial pigmentation in Dalmatian dogs, mink, white cats and mice ‬‬‬(Nadol and Burgess, ; Sampaio et al., ). Additionally, the mechanisms of age‐related hearing loss (presbyacusis) and the influence of acute and chronic noise exposure need to be evaluated histopathologically (Wilson et al., ).‬‬‬‬‬‬‬‬‬…”

Section: Discussionmentioning

confidence: 99%

Histological Study of the External, Middle and Inner Ear of Horses

Blanke

Aupperle

Seeger

et al. 2014

Anat Histol Embryol

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Clinical, anatomical and histological aspects of the equine acoustic organ have been poorly investigated and illustrated in literature so far. It is understood that an intact acoustic organ and hearing function are of vital importance for the well-being of flight animals like horses. The knowledge of the acoustic organ is usually transferred analogously from other mammals to horses. The purpose of this study was to provide a detailed and complete histological description of the healthy equine auditory organ, and to determine its congruity to other mammalians. Anatomical dissections and histological preparations were carried out on ten cadaver heads. Specimens of various parts of the equine acoustic organ were taken and evaluated histologically. The histological composition of external, middle and inner ear structures are predominantly congruent to those of other mammals, especially to human beings. Unique inwardly directed rete pegs within the osseous ear canal and the prominent tensor tympani muscle are described for the first time. Results obtained in this study can be employed as references for further research on the equine acoustic organ and improve the understanding of the clinical development of hearing loss, otitis externa/media/interna or tympanosclerosis.

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“…Cochleosaccular pathology has been reported in the white cat, 21,22,48 the dalmatian [49][50][51] and other dog breeds, 52,53 Hedlund white mink, 54,55 several mouse mutants, 56,57 and as Waardenburg syndrome in humans. 58 As background reference, the normal postnatal maturation of the stria vascularis has been described for the dog 59 and the functional morphology of melanocyte types has been described for the mouse.…”

Section: Cochleosaccularmentioning

confidence: 99%

Hearing disorders in cats: Classification, pathology and diagnosis

Strain

2017

Journal of Feline Medicine and Surgery

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Practical relevance: Auditory function is a sense that is central to life for cats - being important in situational awareness of potential predators, pursuit of prey, and for communication with conspecifics, humans and other species. Deafness in cats is most frequently the result of a genetic disorder, strongly associated with white fur and blue eyes, but may also result from acquired causes such as advancing age, ototoxic drugs, infection, environmental noise and physical trauma. Deafness can be sensorineural, where there is loss of cochlear hair cells, or conductive, where sound is muffled on its way to the inner ear. Clinical challenges: Establishing whether a cat is deaf can be difficult as behavioral testing of hearing is subjective and does not reliably detect unilateral deafness. Brainstem auditory evoked response testing is an objective measure but is limited in its availability. Currently, sensorineural deafness is irreversible because no treatments are available to restore lost hair cells. Conductive hearing loss can usually be treated, although full hearing recovery following otitis media may take weeks as the body clears the middle ear of debris. Evidence base: The author draws on the published literature and his extensive research on clinical aspects and molecular genetics of deafness, principally in companion animals, to review types and forms of deafness in cats. He also discusses current diagnostic approaches and provides brief advice for managing cats with hearing loss.

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Histopathological and Morphometric Study of Cochleosaccular Dysplasia in Dalmatian Dogs

Cited by 3 publications

References 0 publications

Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome‐wide association study analyses

Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome‐wide association study analyses

Histological Study of the External, Middle and Inner Ear of Horses

Hearing disorders in cats: Classification, pathology and diagnosis

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