Histopathological and ultrastructure studies on hepatotoxicity of arsenic in Clarias gariepinus (Burchell, 1822): Hepatoprotective effect of Amphora coffeaeformis

Moneeb, Rehab H.; Mekkawy, Imam A.; Mahmoud, Usama M.; Sayed, Alaa El‐Din H.

doi:10.1016/j.sciaf.2020.e00448

Cited by 10 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in CAT and SOD enzymes were limited by A. coffeaeformis supplementation. These results agree with El-Sayed et al (2018) and Moneeb et al (2020), who suggested that A. coffeaeformis extract can restore antioxidant enzymes to control levels. A. coffeaeformis has antioxidative properties and is considered a natural antioxidant (Lee et al, 2008;Lee et al, 2009) that is able to stimulate a speci c set of biochemical and physiological actions to repel the toxic effects of environmental pollutants (Gaur and Rai, 2001).…”

Section: Discussionsupporting

confidence: 92%

Impacts of microplastics on reproductive performance of male tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis

Ismail

Saleh

Sayed

2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

This study examines the potential defending effects of the diatom, Amphora coffeaeformis, as a feed additive against the deleterious effects (mainly on gonads) caused by microplastics (MPs) in the Nile tilapia, Oreochromes niloticus. Male tilapia groups were pre-fed diets with four different supplementation levels of A. coffeaeformis (0%, 2.5%, 5% and 7.5%) for 70 days, then were exposed to 10 mg/L MPs for 15 days. The results showed signi cantly (p < 0.05) higher numbers of erythrocytes, but signi cant decreases (p < 0.05) in the number of RBCs, Hb, Ht, platelets, and eosinophil percentages. Testicular histological degenerative changes and testis-ova were found in the MPs-exposed sh. Thus, A. coffeaeformis supplementation displayed ameliorative properties that detoxi ed the negative effects of MPs. This study provides a better understanding of the reproductive injuries caused by MPs and provides evidence for the use of A. coffeaeformis as a natural remedy in freshwater tilapia.

show abstract

Section: Discussionsupporting

confidence: 92%

Impacts of microplastics on reproductive performance of male tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis

Ismail

Saleh

Sayed

2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…The rst is the direct damage to liver cells. Dudley et al found that after intravenous injection of 4 mg/kg of Cd to rat, dilation of rough endoplasmic reticulum, loss of ribosomes, and nucleolus condensation were observed in the liver [13][14] . Sakr et al reported that after injecting Cd into rats, vacuoles could be observed in Kupffer cells, which can activate mononuclear macrophages to release a large number of in ammatory factors [15][16] .…”

Section: Introductionmentioning

confidence: 99%

Study on the Role and Mechanism of HDAC6 in Cd-Induced Inflammation and Fibrosis in Mice Liver

Fan Guo,

Lei,

Huang

et al. 2023

Biol Bull Russ Acad Sci

View full text Add to dashboard Cite

The heavy metal cadmium (Cd) is one of the major environmental pollution toxicants, which is highly toxic to the environment and can cause damages to many organs after entering human body. Studies have shown that Cd pollution is characterized by long-cycle and insidiousness, and long-term Cd exposure can lead to liver brosis, but the mechanism remains unclear. This study employed a Cdinduced liver brosis mouse model to investigate the health effects for toxic of Cd exposure by oral administration on in ammation and brosis of liver, and to further explore the role and mechanism of histone deacetylase 6 (HDAC6) in this model. Results showed that the Cd exposure induced in ammation and brosis of mice liver in a dose-dependent manner. Based on Western blotting and immuno uorescence analysis, we found that HDAC6 was involved in Cd-induced liver in ammation and brosis. Inhibition of HDAC6 attenuated Cd-induced in ammation and brosis probably by regulating endoplasmic reticulum (ER) stress. Our ndings provide new insights into the health effects for the liver damage induced by Cd exposure, highlighting that HDAC6 may be a potential target for therapy against Cd-induced in ammation and brosis in liver.

show abstract

Poison in the water: Arsenic's silent assault on fish health

Chandel,

Sharma,

Thakur

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

Arsenic occurs across the world in freshwater and marine environments, menacing the survival of aquatic organisms. Organic and inorganic forms of this substance can be found, in which the inorganic form is more hazardous than the organic form. Most aquatic bodies contain inorganic arsenic species, but organic species are believed to be the dominant form of arsenic in the majority of fish. Natural and anthropogenic both are the sources of water contamination with arsenic. Its bioaccumulation and transfer from one trophic level to another in the aquatic food chain make arsenic a vital environmental issue. Continuous exposure to low concentrations of arsenic in aquatic organisms including fish leads to its bioaccumulation, which may affect organisms of higher trophic levels including large fishes or humans. Humans can be exposed to arsenic through the consumption of fish contaminated with arsenic. Hence, the present review facilitates our understanding about sources of arsenic, its bioaccumulation, food chain transfer, and its effect on the fish health. Also, “Poison in the Water: Arsenic's Silent Assault on Fish Health” serves as a wake‐up call to recognize the pressing need to address arsenic contamination in water bodies. By understanding its devastating impact on fish health, we can strive to implement sustainable practices and policies that safeguard our precious aquatic environments and ensure the well‐being of both wildlife and human communities that depend on them.

show abstract

Histopathological and ultrastructure studies on hepatotoxicity of arsenic in Clarias gariepinus (Burchell, 1822): Hepatoprotective effect of Amphora coffeaeformis

Cited by 10 publications

References 27 publications

Impacts of microplastics on reproductive performance of male tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis

Impacts of microplastics on reproductive performance of male tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis

Study on the Role and Mechanism of HDAC6 in Cd-Induced Inflammation and Fibrosis in Mice Liver

Poison in the water: Arsenic's silent assault on fish health

Contact Info

Product

Resources

About