Histopathological changes in the liver and kidney tissues of Wistar albino rat exposed to fenitrothion

Abstract

The aim of this study was to investigate the dose-related effects of fenitrothion (FNT) on the liver and kidney. The study was conducted on 8-week-old male Wistar rats that were divided into four groups (three experimental groups and one control group) and were treated orally with different doses (25, 50, 100 mg/kg) of FNT for 28 consecutive days. After treatment, the rats were anesthetized with ether and liver and kidney samples were taken for histological studies. The results showed that the histopathological changes in the liver were mainly represented by parenchymatous degeneration of hepatocytes with mild necrosis, leukocytic infiltration in the portal area, severe congestion, and hemorrhage. These changes were dose dependent. Marked tubular dilation, hydropic degeneration in tubular epithelium, moderate congestion, and hemorrhage in the cortical and medulla part of the kidney were recorded. Histopathologic examination of the liver and kidney indicated a significant injury only in rats receiving 100 mg/kg FNT.

Antioxidant Effect of Clorella vulgaris on Wistar Rat Kidney Induced by CCl4: A Histopathological Review

“…Current study also showed dilatation, vacuolation, and brush border loss of tubule cell. These findings also relevant to study by Ogeturk (2005), Adewole (2007), and Ashafar (2008), which showed similar damage on tubule cell of wistar rats after CCl 4 administration.…”

Toxicological studies for some agricultural waste extracts on mosquito larvae and experimental animals

“…Moreover, fenitrothion and dichlorvos are a contactacting organophosphate insecticide which inhibits acetylcholinesterase activity, thus disrupting the nervous system [24][25][26][27][28] . The pattern of cholinesterase inhibition was in good agreement with the probable runoff of pesticides from agricultural fields [29,30] .…”

“…Each dose from both compounds was dissolved in 0.5 mL water and was administered orally to rats using stomach tube with ball tipped oral incubated needle. The LD 50 value of the two compounds was calculated, for 24 h. mortalities following each treatment.…”

Water Quality and Hispathology of Climbing Perch (Anabas testudineus Bloch) at Cempaka Mining, South Kalimantan, Indonesia

“…There are four categories of damage level based on semi quantitative scale (Di Giulio & Hinton, 2008;Afshar, et al, 2008; Safahieh, et al, 2012). They are: (-) = none; (+) = mild (achieving 25% in 1 visual field); (++) = moderate (achieving 50 % in 1 visual field); and (+++) = severe (achieving75% -100% in 1 visual field).…”

“…They are fixation, dehydration, clearing, infiltration, embedding, sectioning, affixing, defarafinisation, staining, mounting, and labeling. Observation and calculation of the amount of liver organ cell in tissue was done with binocular microscope Olympus BX41 with 400 times of zooming in and photographing using digital camera Olympus CX21FS1.There are four categories of damage level based on semi quantitative scale (Di Giulio & Hinton, 2008;Afshar, et al, 2008; Safahieh, et al, 2012). They are: (-) = none; (+) = mild (achieving 25% in 1 visual field); (++) = moderate (achieving 50 % in 1 visual field); and (+++) = severe (achieving75% -100% in 1 visual field).…”