2019
DOI: 10.1111/his.13785
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Histopathological diagnosis of persistent pruritic eruptions associated with adult‐onset Still's disease

Abstract: Aims Persistent pruritic eruptions (PPEs), presenting with dyskeratotic keratinocytes histologically, are characteristic skin rash in patients with adult‐onset Still's disease (AOSD). The lesions may be histologically similar to other entities that present with dyskeratosis. In the present study, we compared the histopathological features between PPEs and other entities presenting with dyskeratosis. Methods and results To investigate whether histopathological findings can be used to discriminate among PPEs and… Show more

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Cited by 18 publications
(18 citation statements)
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“…Histopathologically, the eruption is characterized by the presence of singly or aggregated dyskeratotic/necrotic keratinocytes in the upper layers of the epidermis, accompanied by perivascular inflammatory infiltrates in the upper and middle dermis, without vasculitis ( 32 , 33 ). SLE can present with various types of skin lesions, but unlike AOSD, in persistent pruritic eruptions of SLE, dyskeratotic keratinocytes are rarely found in the upper layers of the epidermis ( 34 ). The clinical and pathological findings of the rash in our patient’s case fit the atypical skin manifestations of AOSD.…”
Section: Discussionmentioning
confidence: 99%
“…Histopathologically, the eruption is characterized by the presence of singly or aggregated dyskeratotic/necrotic keratinocytes in the upper layers of the epidermis, accompanied by perivascular inflammatory infiltrates in the upper and middle dermis, without vasculitis ( 32 , 33 ). SLE can present with various types of skin lesions, but unlike AOSD, in persistent pruritic eruptions of SLE, dyskeratotic keratinocytes are rarely found in the upper layers of the epidermis ( 34 ). The clinical and pathological findings of the rash in our patient’s case fit the atypical skin manifestations of AOSD.…”
Section: Discussionmentioning
confidence: 99%
“…Although the duration and description of the eruption for our patient are not classic for AOSD, case reports of persistent papular/plaque variant have been described. 4 Vitiligo is an acquired cutaneous disorder characterised by the loss of melanocytes in the epidermis resulting in white patches on the skin. 5 The condition affects 0.5% of the world's population and runs an unpredictable course.…”
Section: Discussionmentioning
confidence: 99%
“…With maturation, the FTSG contours well. 4 In case one, the FTSG regained vermilion colour and consistency (Fig. 1e), whereas in case two, the graft remained hypopigmented with slight bulkiness (Fig.…”
mentioning
confidence: 91%
“…On the other hand, the histopathology from urticarial evanescent rash shows normal epidermis, sparse perivascular, and interstitial neutrophilic infiltration with dermal edema. [ 2 7 12 ]…”
Section: Discussionmentioning
confidence: 99%