Histopathological effects of septoplasty techniques on nasal septum mucosa: an experimental study

Ozdemir, Semih; Çelik, Hatice; Cengiz, Ceyhun; Zeybek, Naciye Dilara; Bahador, Elham; Aslan, Necmi

doi:10.1007/s00405-018-5226-7

Cited by 11 publications

(6 citation statements)

References 10 publications

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“…In the DL area, after the removal of all tissue including bone, the regenerated tissue had different characteristics, and had degenerated into a combination of stratified squamous and respiratory epithelia. This difference in degeneration may be explained by the presence of the septal nasal cartilage in the NS area as a support base, acting to prevent mucosal degeneration after mucosal resection ( Ozdemir et al, 2019 ). Provided that mucosal regeneration advances smoothly following OM resection, olfactory functional outcomes can be maximized after surgery in the OC, allowing the range of surgical options to be broadened.…”

Section: Discussionmentioning

confidence: 99%

Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection

et al. 2021

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Resection of the olfactory mucosa (OM) is sometimes unavoidable during surgery; however, it is not known whether the OM can completely recover thereafter. The aim of this study was to uncover whether the OM fully recovers after mucosal resection and describe the process of OM regeneration. 8-week-old male Sprague–Dawley rats (n = 18) were subjected to OM resection at the nasal septum; six rats were euthanized for histological examination 0, 30, and 90 days after surgery. Immunohistochemistry was performed to identify olfactory receptor neuron (ORN) lineage cells [mature and immature ORNs and ORN progenitors, and olfactory ensheathing cells (OECs)], as well as dividing and apoptotic cells. Squamous and respiratory metaplasia and inflammatory cell infiltration were also assessed. On day 30 after resection, the mucosa had regenerated, and mainly contained thin nerve bundles, basal cells, and immature ORNs, with a few mature ORNs and OECs. On day 90, the repaired nasal mucosa had degenerated into stratified squamous or ciliated pseudostratified columnar epithelia, with reducing ORNs. The lamina propria contained numerous macrophages. Partial regeneration was observed within 1 month after OM resection, whereas subsequent degeneration into squamous and respiratory epithelia occurred within 3 months. Given the poor persistence of ORNs and OECs, OM resection is likely to result in olfactory impairment. Overall, surgeons should be cautious not to injure the OM during surgery.

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Section: Discussionmentioning

confidence: 99%

Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection

et al. 2021

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“…Smoking and alcohol use are not required in patients undergoing nasal septum surgery. They have a negative effect on wound healing [12]. In a study conducted by Yazici et al [13], cigarette smoking has been shown to decrease postoperative quality of life in patients undergoing septoplasty.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for nasal septal perforation after septoplasty operation

Yıldız¹,

Ulu²,

Kahveci³

2019

Journal of Surgery and Medicine

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Aim: Nasal septal perforation is the most common complication in the long term after septoplasty. Nasal septal perforation is the partial opening of the wall between both nasal cavities. In this study, we will evaluate the causes of septal perforation after septoplasty. Methods: 400 patients aged between 18 and 50 years who underwent septoplasty operation in Otorhinolaryngology clinic between 2016 and 2019 were evaluated. The study was performed as a retrospective cohort. These patients were divided into groups with and without perforation. Patients with perforation were evaluated in terms of age, gender, alcohol and cigarette use, and stabilization technique used in surgery. Results: There were 280 male and 120 female patients in the study. 378 patients had no postoperative septal perforation. 22 had perforation after surgery. 19 of the patients in the perforated group were male and 3 were female. Male sex ratio was significantly dominant in perforated patients (19/3) (P=0.022). 21 of the patients were smoking and 1 patient was not drinking. (P=0.012). 11 of these patients were drinking alcohol and 10 of them did not drink alcohol. To stabilize the septum in patients with perforation while transseptal suturation + nasal splint was used in 14 patients, only nasal splint was used in 8 patients. The perforation rate after surgery was 22/400 (1.3%) (21/1) (P=0.012). There was no significant difference in the perforation rate among the patients with alcohol intake (P=0.082). There was significant difference between the methods used to stabilize the septum. The rate of perforation was significantly increased in patients who underwent transseptal suturation (P=0.023). Conclusion: Patients with perforation after septoplasty were found to increase the risk of perforation by male sex, smoking and surgical technique as transseptal suturing technique.

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“…Smoking and alcohol use are not required in patients undergoing nasal septum surgery. They have a negative effect on wound healing [12]. In a study conducted by Yazici ZM, et al Cigarette smoking has been shown to decrease postoperative quality of…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

J Otolaryngol Rhinol

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Histopathological effects of septoplasty techniques on nasal septum mucosa: an experimental study

Cited by 11 publications

References 10 publications

Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection

Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection

Risk factors for nasal septal perforation after septoplasty operation

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