Histopathological Evaluation of Orchiectomy Specimens in 51 Late Postpubertal Men with Unilateral Cryptorchidism

Koni, Artan; Özşeker, Havva Solak; Arpalı, Emre; Kilinc, Ercument; Doğan, Hasan Serkan; Akyol, Aytekin; Tekgül, Serdar

doi:10.1016/j.juro.2014.05.048

Cited by 32 publications

(26 citation statements)

References 25 publications

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“…Half of the study population still had significant germ cell activity at different maturation levels. Importantly, the incidence of intratubular germ cell neoplasia was 2% [64].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Radmayr

Doğan

Hoebeke

et al. 2016

Journal of Pediatric Urology

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173

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“…Half of the study population still had significant germ cell activity at different maturation levels. Importantly, the incidence of intratubular germ cell neoplasia was 2% [64].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Radmayr

Doğan

Hoebeke

et al. 2016

Journal of Pediatric Urology

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173

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“…[146][147][148][149] In postpubertal men who are subfertile or infertile, the prevalence of GCNIS has been found to range from approximately 1% to 4%, although this depends on selection criteria for biopsy and the population demographics. [150][151][152] Germ cell neoplasia in situ is also associated with microlithiasis (although this finding is nonspecific), 153 which may partially account for the scrotal ultrasound irregularities that are often seen in testes with GCNIS.…”

Section: Epidemiology and Clinical Significance Of Gcnismentioning

confidence: 99%

Precursor Lesions of Urologic Malignancies

Khani¹,

Robinson²

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Precursor lesions of urologic malignancies are established histopathologic entities, which are important not only to recognize for clinical purposes, but also to further investigate at the molecular level in order to gain a better understanding of the pathogenesis of these malignancies. Objective.— To provide a brief overview of precursor lesions to the most common malignancies that develop within the genitourinary tract with a focus on their clinical implications, histologic features, and molecular characteristics. Data Sources.— Literature review from PubMed, urologic pathology textbooks, and the 4th edition of the World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs. All photomicrographs were taken from cases seen at Weill Cornell Medicine or from the authors' personal slide collections. Conclusions.— The clinical importance and histologic criteria are well established for the known precursor lesions of the most common malignancies throughout the genitourinary tract, but further investigation is warranted at the molecular level to better understand the pathogenesis of these lesions. Such investigation may lead to better risk stratification of patients and potentially novel treatments.

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“…Data of 222 cases with known testicular volume, location and pathology results were evaluated separately from 97 cases with known semen analysis. Mean age of patients was 21.26±0.85 and median age was 21 (19)(20)(21)(22)(23)(24). Mean testicular volume of pathological specimens was 6.90±5.81 cc [median 6 cc (0.1-30)].…”

Section: Resultsmentioning

confidence: 99%

“…Rogers et al [4] detected CIS in only 2 (4%) out of 50 cases, and in another recent study one case of CIS out of 51 patients was found. [22] However it must be kept in mind that about 50% of CIS cases can develop into invasive tumors within 5 years. [6,23,24] In our study, we diagnosed only one patient with seminoma (0.4%) by coincidence On the contrary, a study done in Welvaart-Netherlands concluded that orchiectomy should be performed only after an accurate tumor diagnosis is made since the exact risk of cancerogenesis is unknown.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathological results of the adult patients with unilateral cryptorchidism patients

Ateş

Soydan

Okçelik

et al. 2016

Turkish Journal of Urology

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Objective: To evaluate the clinical and histopathological results of adult unilateral cryptorchidism patients. Material and methods:Data from adult unilateral cryptorchidism patients that underwent orchiectomy in our clinic between between January 2004 and March 2013 were retrospectively evaluated. Patients were divided into three groups as intra-abdominal, inguinal canal and superficial inguinal region according to the location of the undescended testes. Patients were also grouped according to their testicular volume (<4 cc, 4.1-12 cc, and >12 cc). Histopathology results of orchiectomy specimens were classified as follows: 1. Sertoli cells only, testicular atrophy and vanished testis (anorchia) 2. Hypospermatogenesis, and 3. Maturation arrest. Patients were grouped as normospermia, azoospermia and oligo/astheno/teratospermia groups according to semen analysis results. Correlations between testicular localization, testicular size, semen analysis and pathology results were evaluated. Incidental tumor detection rates were also calculated.Results: Two hundred and forty-four adult unilateral cryptorchidism patients underwent orchiectomy in our clinic. There was no a significant relationship between location of the testis and testicular pathology results (p= 0.707). Most common semen analysis results was normospermia in patients with high testicular volume group however azoospermia and oligoasthenospermia observed commonly in patients with low testicular volume group. There was a significant relationship between testicular volume and semen analysis results (p= 0.023). No significant relationship was observed between semen analysis and pathological results (p= 0.929). After an evaluation of all factors with possible effects on the semen analysis results, only testicular volume (p= 0.036) was found to have a significant impact. Only one case (0.4%) was incidentally diagnosed seminoma after a review of 233 patients with available histopathological results on record. Conclusion:Adult unilateral cryptorchidism has a minimal effect on male fertility or even this effect can be overlooked. Low detection rates of incidental germ cell tumors also make an orchiectomy decision questionable in such cases.

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Histopathological Evaluation of Orchiectomy Specimens in 51 Late Postpubertal Men with Unilateral Cryptorchidism

Cited by 32 publications

References 25 publications

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Precursor Lesions of Urologic Malignancies

Clinical and histopathological results of the adult patients with unilateral cryptorchidism patients

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