Histopathological Evaluation of Prostate Lesions: A Comprehensive Approach

Abstract

This chapter encompasses the spectrum of prostatic diseases seen routinely in the evaluation of prostate biopsy or resection specimens. It covers the basic anatomy and histology, along with tissue examination and processing. The common benign conditions such as benign prostatic hyperplasia (BPH), various kinds of prostatitis, etc., are addressed briefly and prostate adenocarcinoma is discussed in a structured pattern, including the morphological variants, IHC, molecular profiling, microscopic variants, grading, mimickers, etc. Other rare tumors of the prostate are also discussed in brief. This chapter provides a comprehensive update on the 2022 WHO classification of urinary and male genital tumors.