Histopathological evidence of intrahepatic cholangiocarcinoma occurring in ductal plate malformation: A clinicopathologic study of 5 cases

Wang, Qian; Xu, Yi; Wang, Shou‐Mei; Hu, Ai-Yan; Pan, Yun-Cui; Zhang, Shu‐Hui

doi:10.1016/j.anndiagpath.2021.151828

Cited by 5 publications

(9 citation statements)

References 22 publications

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“…Usually combined with sarcomatoid carcinoma, SICC has a worse prognosis than ICC [10]. Chinese scholars have reported that the median postoperative survival time of SICC patients is only 6 months, and those with a tumor less than 2 cm in diameter only survives one year after complete tumor resection [8]. In the present case, rib metastasis occurred one month after partial liver resection.…”

Section: Discussionmentioning

confidence: 51%

“…Sarcomatoid intrahepatic cholangiocarcinoma (SICC) is a pathological subtype of intrahepatic cholangiocarcinoma (ICC) [1][2][3], which has been rarely reported in imaging studies [4][5][6][7][8][9]. SICC and general ICC display similar features on conventional 2-D grayscale ultrasound images: low echo, halo shapes, and detectable internal arterial spectrum.…”

Section: Discussionmentioning

confidence: 99%

“…Because medical imaging methods cannot confirm the diagnosis of SICC, radiologists usually misdiagnose SICC as hepatocellular carcinoma, intrahepatic cholangiocarcinoma or others. The definite diagnosis of SICC depends on pathological and immunohistochemical characteristics [8][9]: (1) malignant epithelial and spindle cell sarcomatoid components, a transitional type between the two types of components, and a proportion of sarcomatoid components > 50%; (2) strongly positive epithelial markers such as CK and EMA, weakly positive or negative mesenchymal markers. Sarcomatoid spindle cells can weakly express mesenchymal markers such as SMA and Vimentin.…”

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid Intrahepatic Cholangiocarcinoma: A Case Report

Wang¹,

Ye²

2023

Advanced Ultrasound in Diagnosis and Therapy

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Conventional two-dimensional ultrasonography revealed a hypoechoic mass in the liver of a middle-aged male patient. Enhanced ultrasound suggested intrahepatic cholangiocarcinoma. Enhanced MRI confirmed it as liver cancer. The patient underwent partial liver resection and was pathologically diagnosed as sarcomatoid intrahepatic cholangiocarcinoma. Pulmonary infection occurred one month after surgery. Chest CT suggested left rib metastasis and then radiotherapy was performed. The patient was treated with Lenvatinib after discharge. No recurrence was observed within 36 months. He survived much longer than other patients reported in the literature. The survival of patients with intrahepatic cholangiocarcinoma can be prolonged through early detection and treatments of surgery, radiotherapy and targeted therapy.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid Intrahepatic Cholangiocarcinoma: A Case Report

Wang¹,

Ye²

2023

Advanced Ultrasound in Diagnosis and Therapy

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“…It is well-known that ductal plate malformation of the bile duct is a precursor to biliary intraepithelial neoplasia that can transform to an invasive carcinoma. 5,6 Intrahepatic cholangiocarcinoma with ductal plate malformation pattern was first recognized as a distinctive variant by Nakanuma in 2012. 3 Intrahepatic cholangiocarcinoma with ductal plate malformation pattern is rare, with a low incidence in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Since 2012, only 4 cases including the present case have been reported. [3][4][5] The clinicopathological features of combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern have not been clarified. Analyzing the molecular features of combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern may be helpful to elucidate the pathogenesis of this entity.…”

Section: Introductionmentioning

confidence: 99%

Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis

Moon

Song

et al. 2023

Int J Surg Pathol

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Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 × 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A, CHD4, CYP2D6, ERBB3, KIR3DL1, KRAS, MDM2, PIM1, STAT6, TPMT amplification, FANCD2, FAT1, FLT4, RASA1, and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern.

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Wogonin inhibits hepatoma cell proliferation by targeting miR‐27b‐5p/YWHAZ axis

Ma,

Wang,

Wang

et al. 2023

J Biochem & Molecular Tox

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Wogonin (5,7‐dihydroxy‐8‐methoxyflavone), a natural flavonoid compound in herbal plants, can suppress growth in hepatocellular carcinoma (HCC). However, the microRNA (miRNA) expression profiles that are influenced by wogonin have not been thoroughly described. To explore the novel miRNAs and the biological mechanism underlying the effect of wogonin on HCC cells. The effect of wogonin on Huh7 cell growth was assessed both in vitro and in vivo. The expression profiles of miRNAs were obtained by small RNA sequencing. Luciferase reporter experiment and bioinformatics analysis were conducted to determine whether tyrosine 3‐monooxygenase/tryptophan 5‐monooxygenase activation protein zeta (YWHAZ) can bind to miR‐27b‐5p. Effects of the ectopic expression of YWHAZ and miR‐27b‐5p on Huh7 cells proliferation and apoptosis were evaluated. Furthermore, the cell cycle, apoptosis and multiple signaling pathway‐related molecules were detected by Western blot analysis. Wogonin substantially inhibited the growth of Huh7 cells both in vitro and in vivo. Seventy miRNAs exhibited greater than twofold changes in wogonin‐treated cells. Upregulation of miR‐27b‐5p inhibited Huh7 cell proliferation, and the anticancer effect of wogonin was reversed after miR‐27b‐5p knockdown. miR‐27b‐5p directly targeted YWHAZ in HCC cells. The proliferation‐inhibiting effect of miR‐27b‐5p was revoked by YWHAZ overexpression. Meanwhile, inhibition of HCC growth was achieved by downregulating YWHAZ. Wogonin exerted antitumor activity through multiple signaling molecules, such as focal adhesion kinase, protein kinase B, mammalian target of rapamycin and molecules related to apoptosis and cell cycle by upregulating miR‐27b‐5p and downregulating YWHAZ. Our findings suggest that miR‐27b‐5p/YWHAZ axis contributes to the inhibitory effect of wogonin in HCC by targeting related genes and multiple signaling pathways.

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Histopathological evidence of intrahepatic cholangiocarcinoma occurring in ductal plate malformation: A clinicopathologic study of 5 cases

Cited by 5 publications

References 22 publications

Sarcomatoid Intrahepatic Cholangiocarcinoma: A Case Report

Sarcomatoid Intrahepatic Cholangiocarcinoma: A Case Report

Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis

Wogonin inhibits hepatoma cell proliferation by targeting miR‐27b‐5p/YWHAZ axis

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