Histopathological Evidence of the Efficacy of Percutaneous Ethanol Injection in the Treatment of Axillary Osmidrosis: A Promising New Procedure

Asilian, Ali; Abtahi‐Naeini, Bahareh; Shahbazi, Masoom

doi:10.1159/000479433

Cited by 2 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For most patients, it is particularly important to reduce odor and sweating through treatment. Although surgical treatment may lead to compensatory hyperhidrosis after sympathectomy, almost 70% of those patients got relief after the use of oxybutynin, 9 Other nonoperative treatments, such as 2% guronium bromide, botulinum toxin A, anhydrous alcohol, laser, microneedle radiofrequency, can achieve good therapeutic effects in a short period of time, but they all have the disadvantages of short maintenance time and repeated treatment for many times 10–19 . Microwave refers to the electromagnetic wave whose frequency is between 300 MHz and 300 GHz and has the characteristics of penetration, reflection, and absorption.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis

Zhang

Gong

Tang

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

Axillary osmidrosis (AO) and primary hyperhidrosis (PH) are common diseases, but there are still difficulties in treatment. Microwave therapy may become a new method. In order to evaluate long‐time efficacy of patients with AO or PH treated by microwave and to discuss possible mechanism of microwave therapy by combining results of clinical and pathological, the study was carried out. Ten AO or PH patients with moderate or severe level were selected as subjects, and each subject received microwave treatment of bilateral armpits. The follow‐up period lasted 2 years, and the changes of perspiration and odor were evaluated in subjective and objective ways. Each subject took skin biopsy in the treatment area before and after treatment or each follow‐up. Hematoxylin‐eosin and immunohistochemical staining were performed. Both subjective and objective index reflected the significant improvement of AO and PH after treatment (p < 0.05). Dermatology life quality index score decreased by 10.4 ± 4.6 (p < 0.05). The number of apocrine glands decreased significantly after treatment, and most of them changed from secretory phase to quiescent phase. In conclusion, microwave therapy can destroy apocrine sweat glands, reduce number of functional glands, so as to improve symptoms of AO and PH and elevate quality of life, which is safe, effective, and stable.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis

Zhang

Gong

Tang

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

The Initial Exploration of Polidocanol Sclerotherapy for the Treatment of Axillary Osmidrosis: A Retrospective Study

Yao,

Cai,

Zhu

2024

Dermatol Surg

View full text Add to dashboard Cite

BACKGROUND Axillary osmidrosis (AO) is a strong, unpleasant odor that originates from the apocrine axillary glands. Treatments of AO include surgical treatment and nonsurgical treatment. The surgical procedure yields effective results with a low recurrence rate but requires a longer recovery time and has more postoperative complications. Nonsurgical treatments are minimally invasive and safe, but short-term recurrence may occur in some cases. OBJECTIVE Polidocanol sclerotherapy was first described for management of AO. This retrospective study explored the clinical efficacy in relieving symptom of AO assessed by AO severity using the axillary osmidrosis grading system and safety of polidocanol sclerotherapy in treating AO. PATIENTS AND METHODS This retrospective study included 25 patients with AO single-site study, with 12 patients receiving polidocanol (1%) sclerotherapy (the polidocanol group) and 13 receiving botulinum toxin A (BTX-A) injection (the BTX-A group). The short-term efficacy (7 days after injection), the long-term efficacy (6 months after injection), the recurrence rate, and complications were compared between the 2 groups. A p-value of <0.05 was considered statistically significant. RESULTS The short-term efficacies of polidocanol sclerotherapy and BTX-A injection were 100% and 69.2%, which was not clinically significant (p > .05), whereas their long-term efficacies were 100% and 46.2%, respectively (p < .05). The recurrence rates in the polidocanol and BTX-A groups were 25.0% and 84.6%, respectively (p < .05). The complications did not differ significantly between the 2 groups (p > .05). Although the short-term efficacy and complications were comparable between the 2 groups, the long-term efficacy of polidocanol sclerotherapy was superior to BTX-A injection. The polidocanol group has a lower recurrence rate than the BTX-A group. CONCLUSION Polidocanol sclerotherapy may provide an effective and safe treatment with longer efficacy compared to toxin, which is an effective and safe option for AO treatment.

show abstract

Histopathological Evidence of the Efficacy of Percutaneous Ethanol Injection in the Treatment of Axillary Osmidrosis: A Promising New Procedure

Cited by 2 publications

References 10 publications

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis

The Initial Exploration of Polidocanol Sclerotherapy for the Treatment of Axillary Osmidrosis: A Retrospective Study

Contact Info

Product

Resources

About