Histopathological examination of products of conception after first-trimester miscarriage

Thirukumar, M.

doi:10.4038/cjms.v56i1.4946

Cited by 1 publication

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“…Medical Science 27, e348ms3196 (2023) with other studies that reported an increased risk of abortion with advanced maternal age (Thirukumar, 2019;Frick, 2021). Some chromosomal abnormalities showed corresponding morphological features.…”

Section: Analysis Article | Open Accessmentioning

confidence: 80%

Histopathological study for the products of conception from a regional pathology laboratory in Southwestern Saudi Arabia: A 5-year retrospective study

Abdelbagi,

Alshegifi,

Alameri

et al. 2023

Med Sci

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Introduction: Abortion is defined as the ending of a pregnancy before 20 weeks of gestation or the delivery of a fetus that weighs less than 500 grams. Histopathological examination of the products of conception (POC) candiagnose the underlying cause of abortion e.g., molar pregnancy and hydropic alterations. Methodology: Over a period of five years, from 2017 to 2022; a total number of 569 cases of first-trimester abortion curetted material were sent to the regional laboratory, Department of Histopathology, Al-Qunfudah, Saudi Arabia. Clinical data of each case, type of abortion, placental morphology, villus size, villus vascularity and histopathological findings of each POC sample were studied. Results: The mean age of the studied women was (32.74 ± 7.04 years), with a mean number of pregnancies of 4.68 ± 3.07 (range: 0 -25). Out of the studied POC samples n=355 (62.4%) were incomplete abortions, while inevitable abortion was the least frequent type n=15 (2.7%). There was a significant relationship between fibrin, Arias-Stella, hydrophobic changes, and fibrosis with villus size (p= 0.005, 0.001, 0.001, and 0.013, respectively). Additionally, villus vascularity was significantly associated with the histopathology findings; fibrin, fibrosis, Arias-Stella, and hydrophobic changes (p= 0.001, 0.005, 0.001, and 0.001, respectively). Conclusion: Our findings support that most abortions might be due to chromosomal abnormalities suggested by the significant prevalence of small and hypo-vascularized villi in the studied POC. Routine histopathological examination of all POC is mandatory to rule out critical conditions such as molar or ectopic pregnancy.

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Section: Analysis Article | Open Accessmentioning

confidence: 80%