Histopathological findings of an excised varicose vein complicated with chemical phlebitis

Abstract

Sclerotherapy aims to obliterate the varicose veins after injection of the sclerosing substance into vein lumen by causing stenosis, fibrosis and thrombosis through endothelial cell damage, spasm and inflammatory reaction mechanisms. However, there is a limited number of studies investigating the histopathological effects of sclerotherapy to the human veins. In this case report, we evaluated the histopathological results of the in vivo liquid sclerotherapy [Lauromacrogol 400 (40 mg-2% Aethoxysklerol)] on a vein wall specimen surgically excised after development of a painful and non-resorbing thrombus.