Histopathological findings of the urinary bladder epithelium in aged dogs.

Tsunemi, Kunihiko; Ozono, Seiichiro; Yamaguchi, H.; Hayashi, Yoshiki; K, Babaya; Hirao, Yoshihiko; Okajima, Eigoro; Fukushima, Shoji; Niki, Rikio

doi:10.1293/tox.7.73

Cited by 2 publications

(4 citation statements)

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“…These previous studies indicated that dog bladder tumor shows patterns of histogenesis and progression similar to the natural history of human bladder cancer, and that it is highly useful as a model of human bladder cancer. As described in our previous report [16], our histopathological examination of changes in the bladder epithelium of 50 elderly beagle dogs suggested the high utility of beagles for experiments involving bladder carcinogenesis. The present study was undertaken to study histopathologically two types of bladder tumor induced in mongrel dogs.…”

Section: Discussionsupporting

confidence: 67%

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A histopathological mapping study of the urinary bladder tumors induced byN-butyl-N-(4-hydroxybutyl)nitrosamine in dogs

et al. 1997

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Bladder tumors were induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in five Beagles and four mongrel dogs. The tumors were observed for long periods and the tumor progression was traced using histopathological mapping. The results indicated (1) that low-dose BBN over a long period induced multiple low-grade (G1-2) and low-stage (pTa-1) papillary tumors, resembling superficial bladder cancer in humans; (2) that high-dose BBN over a short period induced high-grade (G2-3) and high-stage (pT3b) nonpapillary tumors and carcinoma in situ (CIS) resembling invasive cancer and CIS in humans; (3) that beagle dogs required longer periods and higher total doses of BBN as compared with mongrel dogs; (4) that the tumors induced by low-dose BBN in beagles were observed without BBN as long as the animals lived, and neither increasing numbers of tumors nor malignant features such as deep infiltration and metastasis was observed; and (5) that low-dose BBN seems to induce mild dysplasia, which is followed by Brunn's nest-like proliferation in the lamina propria and nodular change, eventually leading to the development of papillary noninvasive transitional cell carcinoma (TCC); and that high-dose BBN seems to induce severe dysplasia which leads to CIS and nonpapillary invasive TCC. These results may contribute to clarifying the natural history of human bladder cancer.

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Section: Discussionsupporting

confidence: 67%

“…When the urinary bladder mucosa of elderly beagles was examined, the lamina propria of every region of the mucosa in all dogs had Brunn's nests, and the same finding was obtained in 66.7% of younger beagles [16]. Brunn's nests are regarded as representing proliferative changes [8].…”

Section: Discussionmentioning

confidence: 99%

A histopathological mapping study of the urinary bladder tumors induced byN-butyl-N-(4-hydroxybutyl)nitrosamine in dogs

et al. 1997

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“…Papillary shaped-bladder tumors have been known to be more indolent than nodular-shaped ones. This concept is supported by animal model investigations regarding urothelial carcinogenesis [ 23 24 25 26 27 28 29 30 31 ].…”

Section: Favorable Prognosis Of Papillary Bladder Tumors Verified In mentioning

confidence: 81%

“…BBN-induced urothelial carcinogenesis of the bladder in dogs (beagle dogs and mongrel dogs) has been investigated in detail by our colleagues, Okajima et al [ 26 27 28 29 30 ]. When 2 beagles were treated daily with 160 mg of BBN in oral capsules, multifocal papillary G1/G2 tumors were seen 137 weeks after the initiation of BBN treatment.…”

Section: Favorable Prognosis Of Papillary Bladder Tumors Verified In mentioning

confidence: 99%

Active surveillance for nonmuscle invasive bladder cancer

2016

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Nonmuscle invasive bladder cancer (NMIBC) is known to be a heterogeneous malignancy that requires varying treatment modalities and follow-up schedules. Low-grade Ta papillary tumors are categorized as low-risk NMIBC because of their favorable prognosis. There is an expanding movement that overdiagnosis and overtreatment should be avoided considering the economic impact and the patients' quality of life. It has been over 10 years since the initial assessment of active surveillance for low-risk NMIBC suggested its feasibility and safety. However, urologists are still unfamiliar with this treatment option, which can be ideal in appropriately selected patients. In this review article, we focus on active surveillance for low-risk NMIBC and discuss the evidence and rationale for this treatment option. There are several issues to resolve in order to advocate active surveillance as a standard option in selected patients. A specific follow-up protocol including intervals of cystoscopy, urine cytology, urine markers, and other radiographic examinations need to be optimized and validated. Finally, we integrate the available data into the follow-up strategy and propose a new surveillance protocol for active surveillance of recurrent low-risk bladder cancer.

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Histopathological findings of the urinary bladder epithelium in aged dogs.

Abstract: Abstract:Apparently normal urinary bladder of beagle dogs of both sexes were examined histopath

Cited by 2 publications

References 6 publications

A histopathological mapping study of the urinary bladder tumors induced byN-butyl-N-(4-hydroxybutyl)nitrosamine in dogs

A histopathological mapping study of the urinary bladder tumors induced byN-butyl-N-(4-hydroxybutyl)nitrosamine in dogs

Active surveillance for nonmuscle invasive bladder cancer

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