Histopathological, hematological, and biochemical changes in high-latitude fish Phoxinus lagowskii exposed to hypoxia

Yang, Yuting; Wang, Zhen; Wang, Jing; Lyu, Fengming; Xu, Kexin; Mu, Weijie

doi:10.1007/s10695-021-00947-4

Cited by 30 publications

(4 citation statements)

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“…Hypoxia-tolerant organisms employ metabolic inhibition as a key strategy in response to hypoxia, and it is detrimental to most animals (Bickler & Buck, 2007;Richards, 2010). Our previous study confirmed that P. lagowskii is a hypoxic-tolerant fish (Yang et al, 2021). Changes in cholesterol (a modulator of Na + -K + -ATPase) and the percent of docosahexaenoic acid can reduce metabolic rates (Farhat et al, 2020;Harayama & Riezman, 2018).…”

Section: Discussionsupporting

confidence: 69%

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Biochemical, histological, and gene expression analysis in brain and heart in Phoxinus lagowskii under sustained and diel‐cycling hypoxia

Yao

Wang

et al. 2022

J World Aquaculture Soc

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Sustained and diel-cycling hypoxia frequently occurs in high-latitude environments; however, fish's biochemical, physiological, and histological responses to these two conditions remain unknown. Current hypotheses posit that the heart and the brain of fish from high latitudes are integral to their hypoxia tolerance and that fish exhibit different response mechanisms to cope with sustained and dielcycling hypoxic conditions. To test this, we acclimated Phoxinus lagowskii, a high-latitude fish, to ecologically relevant sustained and diel-cycling hypoxia conditions over 28 days. Histological analysis revealed changes in the relative thickness of the layers in the midbrain. There was a prominent upsurge of oxidative stress biomarkers in dielcycling hypoxia (DCH) treatments, with superoxide dismutase and catalase activity. Our data suggested that triglycerides in the heart were elevated in DCH groups but remained unchanged regardless of sustained hypoxia (SH) treatments. The majority of enzyme activities (LDH, PK, PFK, and HK) increased in DCH groups, especially at day 28. The gene expression results indicated that HIF mainly regulated long-term DCH in the heart and regulated SH in the brain. Collectively, these findings reveal that

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Section: Discussionsupporting

confidence: 69%

“…Our previous study confirmed that P . lagowskii is a hypoxic‐tolerant fish (Yang et al, 2021). Changes in cholesterol (a modulator of Na + ‐K + ‐ATPase) and the percent of docosahexaenoic acid can reduce metabolic rates (Farhat et al, 2020; Harayama & Riezman, 2018).…”

Section: Discussionmentioning

confidence: 99%

Biochemical, histological, and gene expression analysis in brain and heart in Phoxinus lagowskii under sustained and diel‐cycling hypoxia

Yao

Wang

et al. 2022

J World Aquaculture Soc

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“…Therefore, the observed suppression of SMR is likely not a contributing factor to the lower P AAS-50 because the HPC and IRAP testing was performed at a similar 50% hypoxia. Other beneficial hypoxia acclimation mechanisms include remodeling of gill secondary lamellae (Brauner and Rombough, 2012;Anttila et al, 2015;Yang et al, 2021), which would reduce the O 2 diffusion distance (Randall, 1982), could improve hypoxia tolerance and could defend ṀO 2peak under ambient hypoxia. Improved cardiovascular O 2 delivery and O 2 utilization by mitochondria are also possible.…”

Section: (A) Sustained Effect Of Improved Aerobic Performancementioning

confidence: 99%

“…In the present study, we were particularly interested in examining the aerobic performance of fish, the development of a hypoxic phenotypic and its reversibility, i.e., would a fish restore its original normoxic respiratory phenotype after being returned to normoxia following hypoxic acclimation, or would a new phenotype emerge? Phenotypic plasticity in response to hypoxia can occur rapidly in fishes and enhances Dybowski, 1869), for example, remodels its entire gill structure after just a 30-min hypoxic exposure (Yang et al, 2021). Similarly, the mangrove rivulus (Kryptolebias marmoratus Poey, 1880) remodels epidermal ionocytes and respiratory traits after just 24 h of air exposure (Blanchard et al, 2019;Dong et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Respiratory plasticity during acclimation to hypoxia and following a recovery in normoxia

et al. 2023

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Phenotypic plasticity manifested after acclimatization is a very important source of biological variability among fish species. We hypothesized that hypoxic acclimation, besides potentially generating a temporary hypoxic respiratory phenotype, would also manifest as a continued benefit after re-acclimation to normoxia. Hence, we holistically characterized the respiratory phenotype of European sea bass (Dicentrarchus labrax) acclimated to normoxia with or without prior acclimation to hypoxia. Compared with the original normoxic phenotype, prior acclimation to hypoxia and return to normoxia produced a 27% higher absolute aerobic scope (AAS), a 24% higher citrate synthase activity in red muscle and a 28% lower excess post-exercise O2 consumption. Additional testing of hypoxia-acclimated fish under normoxia explored the specific effects of hypoxic acclimation. The hypoxic phenotype, when compared with the original normoxic phenotype, had a lower standard metabolic rate, a better hypoxia performance and a lower minimum PO2 for supporting 50% AAS. Given this respiratory malleability, general predictions for marine fish exploiting a more hypoxic future should better consider respiratory plasticity and prolonged effects of hypoxic exposures.

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Effects of structural remodelling on gill physiology

Gilmour,

Turko

2024

J Comp Physiol B

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Histopathological, hematological, and biochemical changes in high-latitude fish Phoxinus lagowskii exposed to hypoxia

Cited by 30 publications

References 100 publications

Biochemical, histological, and gene expression analysis in brain and heart in Phoxinus lagowskii under sustained and diel‐cycling hypoxia

Biochemical, histological, and gene expression analysis in brain and heart in Phoxinus lagowskii under sustained and diel‐cycling hypoxia

Respiratory plasticity during acclimation to hypoxia and following a recovery in normoxia

Effects of structural remodelling on gill physiology

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