Histopathological, immunohistochemical, and biomechanical effects of splenectomy on Achilles tendon healing in rats

Yüksel, Serdar; Güleç, Mehmet Akif; Gültekin, Zeki; Çağlar, Aysel; Beytemür, Ozan; Alagöz, Ender; Eker, Ayşegül Akdoğan; Subaşı, Cansu; Karaöz, Erdal

doi:10.1080/03008207.2018.1483361

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…Proper inflammatory responses are likely to be necessary for tissue regeneration, which may be impaired by the high levels of proinflammatory cytokines . Yuksel et al reported that reduced proinflammatory cytokines (such as IL-1β, TNF-α) and unregulated anti-inflammatory cytokines (such as IL-2, IL-10) positively influenced Achilles tendon healing . We also found that the secretions of IL-2, IL-4, IL-10, and IL-17 significantly increased in the TEDA group compared with the DA group from months 1 to 3, which is an important period of ACL ligament remodeling and tendon–bone healing.…”

Section: Discussionsupporting

confidence: 65%

“…48 Yuksel et al reported that reduced proinflammatory cytokines (such as IL-1β, TNF-α) and unregulated anti-inflammatory cytokines (such as IL-2, IL-10) positively influenced Achilles tendon healing. 49 We also found that the secretions of IL-2, IL-4, IL-10, and IL-17 significantly increased in the TEDA group compared with the DA group from months 1 to 3, which is an important period of ACL ligament remodeling and tendon− bone healing. IL-17-treated tenocytes were reported to increase the expression of collagen III.…”

Section: ■ Discussionsupporting

confidence: 51%

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Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction

Zhu

Wang

et al. 2020

ACS Biomater. Sci. Eng.

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Anterior cruciate ligament (ACL) reconstruction with allografts is limited by high immunogenicity, poor cellularization, and delayed tendon–bone healing. Decellularized tendons (DAs) have been used as bioscaffolds to reconstruct ligaments with variable success. In the study, four kinds of decellularized allogeneic hamstring tendons were prepared and their microstructure and cytocompatibility were examined in vitro. The results showed that decellularized allografts neutralized by 5% calcium bicarbonate had typical reticular and porous microstructures with optical cytocompatibility. Tissue-engineering decellularized allografts (TEDAs) were prepared with the selected decellularized allografts and tendon stem/progenitor cells and used for ACL reconstruction in a rabbit model. Histological staining showed that the TEDAs promoted cellular infiltration and new vessel formation significantly and improved tendon–bone healing moderately compared to decellularized allografts. Better macroscopic scores and biomechanical results were observed in TEDA groups, but there were no significant differences between DA and TEDA groups at months 1, 2, and 3 postoperatively. Immunohistochemical data showed that the tissue-engineering decellularized allografts enhanced the expression of collagen I at each timepoint and collagen III at months 1 and 2. ELISA analysis showed that the tissue-engineering decellularized allografts reduced the secretion of IgE and IL-1β within 1 month and promoted the secretion of IL-2, IL-4, IL-10, and IL-17 after 1 month. The results showed that tissue-engineering decellularized allografts strengthened intra-articular graft remodeling significantly and provided moderate improvements in tendon–bone healing by creating more suitable immune responses than decellularized allografts. The study revealed that tissue-engineering decellularized allografts as a promising option for ACL reconstruction could achieve more favorable outcomes.

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Section: Discussionsupporting

confidence: 65%

Section: ■ Discussionsupporting

confidence: 51%

Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction

Zhu

Wang

et al. 2020

ACS Biomater. Sci. Eng.

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“…However, the levels of circulating CD4+ and CD8+ T lymphocytes and their alterations should be detected in SCD patients with COVID‐19 to confirm the above hypothesis. (2) Benefit of splenectomy in animal models, with decreased proinflammatory/anti‐inflammatory ratio through a decrease in spleen‐originated inflammatory cells 51 . Since only four SCD patients with splenectomy and good outcomes were reported, 7,11,15,30 the possible benefit of splenectomy against the produced cytokine storm in COVID‐19 patients needs to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Sickle cell disease and COVID‐19: Susceptibility and severity

Sayad

Karimi

Rahimi

2021

Pediatric Blood & Cancer

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We surveyed published papers and an international sickle cell disease (SCD) registry to detect susceptibility and clinical course of coronavirus disease 2019 (COVID‐19) in SCD patients. COVID‐19 presentation was mild in children and moderate in many SCD adults. Regarding increased comorbidities with age, it seems severe COVID‐19 to be more common in older SCD patients. Although the overall outcome of COVID‐19 was favorable in SCD children, a high rate of pediatric intensive care unit admission should be considered in managing these patients. To explain COVID‐19 outcome in SCD patients, the possible benefits of hydroxyurea therapy could be considered. The obtained results should be interpreted, considering low cases from sub‐Saharan people, younger age of SCD patients compared to general population, a bias toward registry of the more severe form of disease, the effect of pre‐existing comorbidities with multisystem organ damage, and the role of health socio‐economic determinants.

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“…The anti-inflammatory effect and inflammatory cytokine reduction have been reported in an animal study after splenectomy. However, the beneficial role of splenectomy against cytokine storms and severe forms of COVID-19 in patients with β-thalassemia needs to be confirmed (37).…”

Section: Splenectomy and Iron Overloadmentioning

confidence: 99%

Thalassemia and COVID-19: Susceptibility and Severity

et al. 2021

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Context: COVID-19 results in an imbalance between procoagulant and anticoagulant homeostatic mechanisms that could be complicated with thrombotic events. In β-thalassemia patients, the presence of comorbidities, iron overload, adrenal hypofunction, splenectomy, and chronic hypercoagulable state might increase the susceptibility to COVID-19 and its severity. Evidence Acquisition: The search was conducted in PubMed, Web of Science, and Scopus databases for the key terms of β-thalassemia/thalassemia and COVID-19 until July 2021. Results: The survey of published observational studies (mostly multicenter and case reports) indicated a lower prevalence of COVID-19 in β-thalassemia patients compared with the general population, as well as mild to moderate COVID-19 in these patients, especially in those without comorbidity. β-Thalassemia children were susceptible to COVID-19 but with less severity compared to adults. There is no report of pulmonary embolism and thrombotic events in β-thalassemia patients with COVID-19; however, coagulation abnormality and pulmonary microembolism have been found in these patients. Conclusions: Findings could be interpreted by the presence of high hemoglobin F (HbF) levels, the advantage of hydroxyurea (HU) therapy, splenectomy, and iron chelation therapy in these patients. However, due to the low sample size and studying mainly young patients, the results should be interpreted with caution, and it still needs more studies with a larger sample size to confirm these findings.

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Histopathological, immunohistochemical, and biomechanical effects of splenectomy on Achilles tendon healing in rats

Abstract: Splenectomy may positively influence Achilles tendon healing through modification of the proinflammatory/anti-inflammatory ratio in favor of anti-inflammatory cytokines by causing a decrease in spleen-originated inflammatory cells.

Cited by 3 publications

References 30 publications

Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction

Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction

Sickle cell disease and COVID‐19: Susceptibility and severity

Thalassemia and COVID-19: Susceptibility and Severity

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