Histopathological Pattern of Abnormal Uterine Bleeding in Endometrial Biopsies

Akram,

doi:10.6000/1927-5129.2012.08.01.25

Cited by 8 publications

(2 citation statements)

References 2 publications

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“…In the present study among physiologic patterns, proliferative was the most common followed by secretory i,e (36.1%) and (20.2%) respectively which is similar to Bhatt s et al (26.23% and 16.39%), Mehnaz roohi et al(21.74% and 12.42%) and Talat mirza et al (10) (35% and 30%).…”

Section: Discussionsupporting

confidence: 86%

Correlation of Menstrual Abnormalities with Endometrial Histopathology: A Review

Neha Khanam,

Nahid Khanam,

J.K. Goel

et al. 2023

IJPHRD

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Background: AUB (Abnormal uterine bleeding) is defined as excessive menstrual blood loss which interferes with women's physical, social, emotional and maternal quality of life. Any uterine bleeding outside the normal volume, duration, regularity or frequency is considered abnormal uterine bleeding (AUB).Objective: To study the various types of menstrual abnormalities prevalent in women and to correlate it with different histopathology features in endometrial curettage. Study Design:The study design was prospective observational study with study population being abnormal uterine bleeding newly registered at the opd/ ipd of Saraswathi Institute Of Medical Sciences, Hapur Uttar Pradesh. A sample size of 136 patients were included during study periods from august 2020 to march 2021.Result: Most common endometrial lesion was endometrial hyperplasia (38.2%), followed by proliferative change (35.29%), others were polyp, fibroid, atrophic endometrium. Endometrial carcinoma was detected in 0.78% of cases.Hyperplasia when further categorised, showed simple hyperplasia as the dominant sub-type. Hyperplasia was the dominant change observed in menorrhagia, polymenorrhoea, metrorrhagia, and postmenopausal bleeding. Conclusion:Most common cause of AUB was hormonal imbalance around perimenopausal age group. In elderly age hyperplasia and malignancy was more commonly seen.

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Section: Discussionsupporting

confidence: 86%

Correlation of Menstrual Abnormalities with Endometrial Histopathology: A Review

Neha Khanam,

Nahid Khanam,

J.K. Goel

et al. 2023

IJPHRD

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“…It was in concordance with study by Mirza et al (5%) and Doraiswami et al (4.4%). 19,21 Carcinoma cases was higher than in studies by Nandkishore et al (1%) and Abdullah et al (1.8%). 4,20 Estrogen receptor status plays prognostic and predictive roles in endometrial cancer.…”

Section: Discussioncontrasting

confidence: 56%

Histopathological evaluation of abnormal uterine bleeding with immunohistochemical study of significant estrogen receptor expression in endometrium of women with different age groups

et al. 2023

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Background: Abnormal uterine bleeding is symptom, not disease. Bleeding per vaginum is labelled to be pathological when there is constant irregularity in pattern and flow of bleeding, altered duration or increased amount of menstrual blood. Histopathological examination of endometrium biopsies remains a gold standard diagnostic tool. Methods: A prospective study was done on 150 patients presenting with AUB over the period January 2022 to December 2022 in the department of pathology, Hind institute of medical sciences, Sitapur, Uttar Pradesh, India. The sections were stained with hematoxylin and eosin and special stain estrogen receptor was used. Results: Majority of the patients were seen in the perimenopausal age group and most common complaint was menorrhagia in 73 patients (48%). The commonest pathology observed in our study was proliferative phase endometrium in 48 patients (32%). Most of the endometrial carcinoma (4%) were presented after the age of 50 years. The association between histopathological patterns and estrogen receptor category were found to be statistically significant as the p<0.05. Conclusions: Disease burden on a global scale is witnessed by women affected by AUB thus having a detrimental impact. Accurate diagnosis of AUB in women over the age of 35yrs is important to rule out preneoplastic lesions and malignancies so that surgical interventions can be avoided by initiating proper medical management. Comparing the hyperplastic and neoplastic endometrium to that of the proliferative phase, ER expression was lower. Endometrial carcinoma with advanced stage often lacks the expression of the receptors.

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