Histopathological Reactions of Calcium Phosphate Cement

Sugawara, Akiyoshi; Nishiyama, Minoru; Kusama, Kaoru; Moro, Itaru; Nishimura, Satoshi; Kudo, Itsuro; Chow, Laurence C.; Takagi, Shōzō

doi:10.4012/dmj.11.11

Cited by 89 publications

(47 citation statements)

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“…The chemical structure of gutta-percha is a trans-isomer of poly-isoprene, or natural rubber; however it is more crystalline than natural rubber and often is formulated with medications such as zinc oxide, iodoform, chlorhexidine and calcium hydroxide, which contribute to both the antibacterial and antifungal activity 4– 7 . Animal studies have shown that gutta-percha becomes encapsulated by fibrous connective tissue with little inflammatory reaction 8 .…”

Section: Discussionmentioning

confidence: 99%

Case report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain

Hodnett

Ferguson

2014

F1000Res

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Section: Discussionmentioning

confidence: 99%

Case report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain

Hodnett

Ferguson

2014

F1000Res

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“…Incidentally, although the size of HA for bone or dentin is about 2.5 to 7.5 nm in width and about 10 to 30 nm in length 25,26) , at this degree of crystal size, resorption by osteoclast is sufficiently possible even if there is some difference in size. This makes it applicable as a bone graft material because bone replacement by bone remodeling is possible [7][8][9][10]23,24,[27][28][29][30][31][32][33][34][35][36][37] . However, even LT-HA becomes non-resorbable when it becomes highly dense and crystalline like enamel due to crystal growth.…”

Section: Discussionmentioning

confidence: 99%

AFM Observations and Composition Analyses of the Top Surfaces of HA Implants

Sugawara

2017

J. Hard Tissue Biology.

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From the perspective of excellent biocompatibility and osteoconductivity of hydroxyapatite (HA), the frequency of use of HA implants has been steadily increasing in recent years. But the coating layer of certain commercialized HA implants may not be primarily composed of HA, and it may be assumed that the coating layers, contained some HA components, are automatically categorized to the HA implant. The characteristics of the implant to vital tissues are attributable to the properties of the surface components of the implant. Scanning electron microscope (SEM) observations and X-ray diff raction (XRD) analyses of the HA coating have been performed previously, but SEM has some diffi culties in showing clear images of the HA crystal due to the infl uence of coating conditions etc., and the results obtained from XRD are not limited to the surface where contact with vital tissues, but also exhibit the inner components of the coating layer. Therefore, it might be assumed that reports limited to the top surface of the HA coating have still not been published. In this study, AFM observations, and XPS and micro-XRD analyses were performed on the top surface of fi ve commercially available HA implants. AFM results showed that HA crystals were clearly observed on the surface of two samples. XPS and micro-XRD analyses exhibited that HA was detected in all the samples, but other substances including Ti, TiO 2 , CaTiO 3 , etc., were also confi rmed in several samples. These results showed that HA was present on the top surface of all HA implants, and also indicated that all implants might exhibit some sort of biocompatibility and osteoconductivity due to their bioactive natures caused by HA.

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“…They can be transformed into apatite crystals in body fluids with excellent biocompatibility and osteoconductivity [8][9] . CPC was also reported to be a useful material for endodontic therapy [10][11] . However, some kinds of CPC are unsuitable for filling root canals because of the formation of pores as the cement hardens 12) .…”

Section: Introductionmentioning

confidence: 99%

Self-sealing ability of OCP-mediated cement as a deciduous root canal filling materia

et al. 2010

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The densification process and canal sealing ability of octacalcium phosphate (OCP)-mediated cement were investigated for developing biocompatible and biodegradable root canal filling material for deciduous root. The results of the characterization revealed that the starting paste, which consisted of monocalcium phosphate monohydrate, calcium carbonate, and α-tricalcium phosphate, gradually transformed into carbonate apatite for 6 weeks of immersion in medium with 30% fetal bovine serum (MEM30). The canal sealing ability was estimated by dye penetration test. Three kinds of conditions were chosen for the test: one was the cement just after filling the single-rooted extracted human roots; the others were the cement aged in MEM30 for 1 and 6 weeks after filling, respectively. All roots were then immersed in India ink for 3 days. The penetration depth of OCP-mediated cement decreased significantly with time. This demonstrates that OCP-mediated cement has self-sealing ability.

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Histopathological Reactions of Calcium Phosphate Cement

Cited by 89 publications

References 1 publication

Case report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain

Case report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain

AFM Observations and Composition Analyses of the Top Surfaces of HA Implants

Self-sealing ability of OCP-mediated cement as a deciduous root canal filling materia

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