Histopathological Relevance in Clinical Spectrum of Hansen’s Disease

Bommakanti, Janardhan

doi:10.18535/jmscr/v4i12.61

Cited by 2 publications

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“…[4] There was a complete agreement with clinical and histopathological diagnosis with 15 cases. The overall clinicopathological concordance was 53.6% similar to the studies done by Tiwari et al 54%, [4] Janardhan Bommakanti et al 56%, [11] Sharma et al 53.44%, [12] Pandya et al 58.13%, [13] and Mithra et al 53%. [16] Various studies showed clinicopathological concordance from 45.3% to 80.4%.…”

Section: Discussionsupporting

confidence: 79%

“…Considering the incidence of cases reported, maximum cases were present in the year 2011 (6 cases) (Fig 1). The maximum Cases diagnosed in clinical and histopathology examination were borderline tuberculoid category both 42.9% and 28.6 respectively ( [7] Mathur et al , [9] Banushree et al [10] Janardhan bommakanti et al [11] Nadkarni NS et al [15] Abdul et al [14] TT …”

Section: Resultsmentioning

confidence: 99%

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India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Ebenezer

Chander

Chitra

2018

APALM

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Background: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. There are various clinico-pathological forms of leprosy depending on the immune status of the host. Diagnosis of leprosy can be done by clinical, microbiological and histopathological examination. Histopathological examination is considered as important for confirmatory diagnosis, for assessment of the disease in patient's under treatment and also for research purposes Methods: A total of 28 skin biopsies of leprosy patients were studied in the Department of Pathology in Saveetha medical college over 7 year's duration (2008 -2015). A Ridley Jopling classification was used for the diagnosis and classification of the disease. All biopsies were stained with haematoxylin and eosin and Fite faraco. Clinico-histopathological correlation was done Result:In this study, number of males (23cases) (82%) were more than the number of females (5 cases) (18%) Mean age of patients was 40 years. The Most common presentation of the lesion was hypopigmented macule involving two areas (13cases). Among 28 cases maximum cases were classified as borderline tuberculoid leprosy (8cases) (28.6%) and least number of cases classified as histiod leprosy (1 case) (3.6%). Fite faraco stain was positive for 3 cases in tuberculoid spectrum and 9 cases in lepromatous spectrum. Conclusion:The current primary goal is early diagnosis of this disease in order to interrupt the transmission by early treatment. Histopathological examination is gold standard in confirmation of its diagnosis and its classification. As new immerging technique become available for the early diagnosis of leprosy, skin biopsies will continue to compliment these for providing more insights into the pathology of this disease.

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Section: Discussionsupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Ebenezer

Chander

Chitra

2018

APALM

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A study on the multidisciplinary diagnostic approach of leprosy: Can we prevent the recrudescence in the post-elimination Indian scenario?

Mukherjee,

Ghatak,

Bhunia

et al. 2023

Journal of Family Medicine and Primary Care

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Introduction: Leprosy also widely known by the name Hansen’s disease is a chronic disease caused by Mycobacterium leprae affecting mankind with various clinico-pathological forms. It remained a major public health issue due to associated case load, morbidity and stigma attached to it. India declared elimination of leprosy in the year 2005. However, it is surprising to see that in some parts of the country, the prevalence is still significant. The objective of the study is to describe the spectrum of histopathological profile of leprosy and compare its correlation with clinical diagnosis in this post elimination era. Methods: A 24-months prospective study was conducted with clinically diagnosed leprosy cases in a tertiary care hospital in eastern India. Lesions were graded and the histopathological slides along with its bacteriological index (BI) on slit skin smears where possible was reviewed and analyzed. Agreement of histopathological finding with clinical finding was established. Results: A total of 220 cases were included in the study. On histopathology, borderline category was the most frequently reported with borderline tuberculoid the most common subtype. Most common clinical feature was hypopigmented plaque, followed by erythematous skin lesions, nodules, macules etc. Bacteriological index was studied in 192 slit skin smears. Moderate agreement between clinical and histopathological diagnosis with kappa measure of inter-rater agreement as 0.457 was noted. Conclusion: Clinico-histopathological correlation is pivotal in the accurate diagnosis of leprosy to prevent, treat, and control the resurgence of the disease in the post-elimination era.

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Histopathological Relevance in Clinical Spectrum of Hansen’s Disease

Cited by 2 publications

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India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

A study on the multidisciplinary diagnostic approach of leprosy: Can we prevent the recrudescence in the post-elimination Indian scenario?

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