BACKGROUND: Gallbladder disease is known to affect a substantial number of people throughout the world. In India, the disease prevalence is
on the rise, largely attributable to dietary & lifestyle changes, thus causing a signicant disease burden. The purpose of this study is to evaluate the
varied histological manifestations of gallbladder pathology and their association with cholelithiasis. MATERIALS & METHODS: This
retrospective study was conducted in the department of pathology, Kilpauk medical college from January 2018 to December 2018. The clinical
data and the histopathological changes were evaluated. RESULTS: Of the 156 cases which were studied, 120 cases (77%) had gallstones. The
mean age was 47 years. Females had a slight preponderance for gallbladder diseases with the Male: Female ratio being 1:2. 138 cases (89.8%) were
diagnosed as chronic cholecystitis. 3 cases were diagnosed to have invasive malignancies. CONCLUSION: A diverse spectrum of diseases affect
the gallbladder encompassing inammatory conditions, parasitic infections, pseudoneoplastic lesions and neoplasms. Routine cholecystectomy
specimens should be evaluated meticulously as incidental ndings and diagnosis can be transformative.