Histopathological spectrum of lichen sclerosus Et atrophicus

Dalal, Varsha; Kaur, Manveen; Bhushan, Chandra; Singh, Avninder; Ramesh, V.

doi:10.4103/ijdpdd.ijdpdd_66_16

Cited by 11 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the clinical diagnosis of genital LS with clinical findings, the diagnosis of extragenital LS often requires histologic confirmation. Hyperkeratosis, epidermal thinning, follicular occlusion, and a band of inflammation composed of lymphocytes with variable vacuolar interface degeneration, dermal edema and deep dermal fibrosis, and a diffuse perivascular lymphocytic infiltration are observed 9 . In this case, histopathological findings confirmed the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of pediatric extragenital lichen sclerosus: A case report

Oğrum¹,

Dürer²

2019

TURKDERM

View full text Add to dashboard Cite

©Copyright 2019 by Turkish Society of Dermatology and Venereology Turkderm-Turkish Archives of Dermatology and Venereology published by Galenos Yayınevi. Turkderm-Turk Arch Dermatol Venereology 2019;53:113-5 Liken sklerozus (LS) etiyolojisi bilinmeyen kronik enflamatuvar bir dermatozdur. Olguların büyük kısmı prepubertal ve perimenopozal dönemde olmakla beraber, hastalık her yaş grubunu etkileyebilir. Ağırlıklı olarak anogenital bölge etkilenmekte olup, ekstragenital tutulum çocuklukta nadir görülür. Anogenital lezyonlar klasik olarak kaşıntılı ve ağrılı beyaz ya da kırmızı yamalar şeklindeyken, ekstragenital lezyonlar sıklıkla asemptomatik beyaz papül ya da yamalar şeklindedir. Ekstragenital lezyonların en sık yerleştiği alanlar gövde, boyun ve aksilladır. Kızlardaki genital LS lezyonlarının çoğunluğu puberte döneminde spontan gerilerken, çocuklardaki ekstragenital LS lezyonlarının prognozuna ilişkin bilgi sınırlıdır. Burada, ekstragenital LS lezyonunda spontan regresyon görülen 14 yaşında bir kız olgu sunuldu.

show abstract

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of pediatric extragenital lichen sclerosus: A case report

Oğrum¹,

Dürer²

2019

TURKDERM

View full text Add to dashboard Cite

show abstract

“…In contrast to anogenital one, the extragenital LS form is not associated with an increased risk of cancer transformation into squamous cell carcinoma. 33 Some authors consider that LS is a superficial variant of morphea occurring mostly in the genital area. 34 Although there are some similarities between LS and morphea, their exact relationship remains debated and those diseases are considered as separate entities.…”

Section: Diagnosismentioning

confidence: 99%

Lichen sclerosus – A review of the literature

Kasprowicz-Furmańczyk

Owczarczyk‐Saczonek

Kwaśny

et al. 2020

Pol. Ann. Med.

View full text Add to dashboard Cite

Introduction: Lichen sclerosus (LS) is a chronic inflammatory dermatosis which may lead to scarring and atrophy of the tissues. It has predilection for the skin and mucoses of anogenital area in men, women and children. The extragenital lesions occur less frequently. The most common symptoms are itching, pain and dyspareunia. The true prevalence of this disease is unknown and probably underestimated due to the underdiagnosis. Therapy of LS often causes many difficulties. Aim: The aim of our review of the literature is to discuss the diagnostic and therapeutic difficulties of LS that may come across doctors of various specializations. We reviewed the literature regarding the etiology, clinical, medical and surgical management of LS. Material and methods: We performed a comprehensive research of the literature in PubMed, Medline and other electronic databases between 1956–2019 using the key words: ‘lichen sclerosus,’ ‘balanitis xerotica obliterans,’ ‘kaurosis vulvae.’ We reviewed 54 articles. Results and discussion: The clinical features and the management vary depending on the age and sex of the patient. To properly treat and prevent possible complications of LS, an interdisciplinary approach to patients care and timely diagnosis of the disease are extremely important. The essence of treatment is to control symptoms, prevent and treat complications and search for early signs of cancer. Conclusions: LS is a disease that presents numerous challenges for doctors specializing in dermatology, gynecology, urology and pediatrics. An interdisciplinary approach is crucial to achieve therapeutic success and patient’s satisfaction.

show abstract

“…Histologically, early LS may show a mild or pronounced bandlike CD8 and CD57 positive lymphocytic infiltrate often accompanied by a lymphocytic vasculitis, basal cell vacuolar degeneration and pigment incontinence. 15 As the lesion progresses, subepidermal oedema develops and there is a loss of elastic fibres within the upper dermis. This gradually becomes replaced by dense fibrosis to create the classic appearance of subepidermal hyalinisation with loss of dermal structures ( Figure 3).…”

Section: The Surgical Specimenmentioning

confidence: 99%

“…Ectatic vessels may be encountered and are a particular feature in lesions previously treated with topical steroids. 15 Gradually, the epidermis becomes more atrophic with flattening of rete ridges and hyperkeratosis. In later stage disease the band-like lymphocytic infiltrate is less pronounced.…”

Section: The Surgical Specimenmentioning

confidence: 99%

“…Both will show homogenised collagen bundles but in morphoea these tend to be located within the deep dermis and subcutaneous tissue. 15 Plasma cell balanitis Plasma cell balanitis (PCB), also known as balanitis circumscripta plasmacellularis, was first described by Zoon, a Dutch dermatologist in 1952 and is now commonly referred to as Zoon's balanitis. 16 This uncommon dermatosis typically affects uncircumcised middle-aged to elderly men.…”

Section: Differential Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

An overview of benign and premalignant lesions of the foreskin

Sewell

Oxley

2019

Diagnostic Histopathology

View full text Add to dashboard Cite

The foreskin is a common surgical specimen encountered by the practising histopathologist. Therapeutic circumcisions are performed to treat both benign and neoplastic foreskin lesions. Penile intraepithelial neoplasia (PeIN) is the precursor lesion of penile squamous cell carcinoma (SCC). The World Health Organisation (WHO) classifies PeIN into two subtypes based on the association with Human Papillomavirus (HPV); these include differentiated and undifferentiated PeIN. These subtypes of PeIN can be differentiated by specific cytological and architectural characteristics. This review article will discuss these histological characteristics and highlight potential difficulties that may arise in diagnosing PeIN. Furthermore, it will also consider common benign and preneoplastic foreskin lesions that may be encountered when reporting the foreskin specimen.

show abstract

Histopathological spectrum of lichen sclerosus Et atrophicus

Cited by 11 publications

References 1 publication

Spontaneous regression of pediatric extragenital lichen sclerosus: A case report

Spontaneous regression of pediatric extragenital lichen sclerosus: A case report

Lichen sclerosus – A review of the literature

An overview of benign and premalignant lesions of the foreskin

Contact Info

Product

Resources

About