Histopathological Spectrum of Non-Malignant Lesions of Gastrointestinal Tract- An Institutional Study.

Khatib, Wasim M.; Demde, Rakesh B.; Aher, Vidya Chandrashekhar; Patel, Pankti

doi:10.9790/0853-151002113116

Cited by 5 publications

(5 citation statements)

References 8 publications

(7 reference statements)

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“…A study done by Sabharwal., et al [18] and Kamal.,et al [11] support this trend, which is specified by their figures. Gastrointestinal (GI) cancers account for about 20% of estimated new cancer cases and 15% of estimated mortality worldwide [1]. Organ-wise distribution of malignancies in our study signifies the most common organ involved were co-lon, rectum and anal canal (43.7%) with least common being tumors involving the small intestine (2.2%), which is in accordance with other studies in literature carried out by Kamal., et al [11].…”

Section: Colo-rectumsupporting

confidence: 91%

“…Given its sheer length and extent, there is a possibility of various pathologies affecting individual segments of the entire tract. Ranging from congenital anomalies, inflammatory conditions to neoplastic conditions including both, benign as well as malignant lesions, the spectrum of diseases which can occur individually or in combination with various segments is wide [1].…”

Section: Introductionmentioning

confidence: 99%

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Histomorphology Spectrum of Gastrointestinal Lesions in A Tertiary Care Centre

Bamanikar¹,

Sankawade²,

Bamanikar³

et al. 2019

Act Scie Canbio

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Introduction: Today gastrointestinal (GI) pathology is accepted as one of the largest sub-specialties in pathology. Histopathological evaluation of GI lesions is the gold standard for providing essential diagnostic and prognostic information to clinicians for the best and timely management of each patient. Aims and Objectives:To study the pattern of gastrointestinal non-neoplastic and neoplastic lesions and the correlation between age, sex and site distribution of various lesions. Material and Methods:This is a unicentre retrospective and prospective study of 2941 patients with GI lesions over a period of four years from January 2015 to December 2018. Biopsies and resected specimens of gastrointestinal tract were fixed in 10% Formalin. These specimens were then; processed in automatic tissue processor. Routine Hematoxylin and Eosin stain and special stains, including immunohistochemical stains were done; wherever indicated. The slides were examined and the data generated from observations was used for statistical analysis.Results: Out of a total 21831 histopathology specimens received in the four years, over 17 % specimens were GIT lesions. Of the 3738 GI specimens, appendix was the most common specimen received (26.9%) followed by gastric specimens (23.2%) and small intestine specimens (18.9%). Non-neoplastic GI lesions (94.5%) were most common followed by neoplastic lesions (5.5%).Males outnumbered female patients having M: F ratio of 1.2:1. The peak incidence for non-neoplastic lesions was found in the age group of 21-40 years and that for neoplastic lesions found in the age group of 50-70 years. Appendicitis was the most common GI pathology (26.8%) followed by gastritis (21.1%). Adenocarcinoma was the most common histological malignancy (65.4%) followed by Squamous cell carcinoma (26.7%). Most common lesion of the esophagus was squamous cell carcinoma whereas adenocarcinoma was common in the colo-rectum. Conclusion:Apart from an overview of the spectrum of histopathological lesions encountered in the surgical pathology department, this study reiterates that histopathological evaluation is a valuable diagnostic tool for definitive, early diagnosis of GI lesions, which has impact on management of the neoplasia.

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Section: Colo-rectumsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Histomorphology Spectrum of Gastrointestinal Lesions in A Tertiary Care Centre

Bamanikar¹,

Sankawade²,

Bamanikar³

et al. 2019

Act Scie Canbio

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“…In the present study 50(9.76%) specimens were from esophagus, of which 43 (86%) were neoplastic with 42 (97.6%) were malignant tumors and one (2.4%) case was of leiomyoma .Among the malignant lesions all were squamous cell carcinomas. The affected age group in our study various form 21-80 years with more commonly affected age group beign 51-60 years which was similar to studies reported by Sunitha Bamanikar et al 1 and Khatib et al 11…”

Section: Esophagussupporting

confidence: 91%

Histopathological spectrum of gastrointestinal lesions - In a tertiary care centre

GK,

2024

ACHR

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Gastrointestinal (GI) pathology is one of the largest sub- specialities in pathology. Histopathological evaluation of GI lesions is the gold standard for providing essential diagnostic and prognostic information to the clinicians for the best timely management of each patient. : This is an unicenter retrospective and prospective study of 510 patients with GI lesions over a period of 2 years from July 2021 to June 2023. Biopsies and resected specimens of gastrointestinal tract were fixed in 10% formalin. Those specimens were then processed in automatic tissue processor. Routine Haematoxylin and Eosin stain and special stains, including immunohistochemical stains were done, whenever indicated. Then slides were examined and data generated from observation and was used for statistical analysis. Out of total 2462 histopathological specimens received in 2 years, over 21% of specimens were GIT lesions of them 510 were GI specimens. Gall bladder was the most common specimen received [34.3%] followed by appendix specimens [18.6%] and gastric biopsies [13.9%]. Non neoplastic GI lesions [89.3%] were the most common followed by neoplastic lesions [10.7%]. Males outnumbered female patients having M: F ratio1.3:1. The peak incidence of non neoplastic lesions are found in the age group of 21-40 years and that for neoplastic lesions found in the age group of 50-70 yrs. Chronic cholecystitis was the most common GI pathology [34.3%] followed by appendicitis [18.1%]. Adenocarcinoma was the most common histopathological malignancy [52.7%] followed by squamous cell carcinoma [47.2%]. Most common lesion in the oesophagus and oral cavity was squamous cell carcinoma whereas adenocarcinoma was most common in colo-rectum. This study enables the overview of the spectrum of histopathological lesion encountered in the surgical pathology department and also reiterates that the histopathological evaluation is a valuable diagnostic tool for definitive and early diagnosis of GI lesions which has an impact on management of neoplastic lesions.

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“…However, yet another study by Khatib W M et al [26] showed a slightly altered report in which the non-neoplastic lesions observed in 75.29% of cases and the neoplastic lesions were seen in 24.71% of cases. The variation in the results may due to personal, nutritional and environmental factors of the individuals.…”

Section: Total 113 100mentioning

confidence: 93%

Evaluating the spectrum of histomorphological patterns on endoscopic biopsy in patients with upper gastrointestinal tract disorders

Theresa

Lavanya

Rakesh

et al. 2020

Trop J Pathol Microbiol

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Introduction: The upper gastrointestinal tract (UGT) disorders are more common complaints in clinical practice and have got high degree of mortality and morbidity. Many different types of lesions can affect the upper gastrointestinal tract and can be classified as congenital anomalies, infections, inflammation and neoplastic lesions. Material and Methods: A total of 152 cases of upper gastrointestinal tract biopsies are included in this study, out of which 113 cases were gastric biopsies, 22 cases were esophageal biopsies and the remaining 17 cases were duodenal biopsies. Present study was carried out in the Department of Pathology at Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry for a period of one year between March 2018 and February 2019. All the biopsies were performed using fiberoptic endoscopy. Endoscopic biopsy in combination with histopathological examination plays an important role in the early diagnosis of determining UGT lesions. Also, special stains like Giemsa, Warthin starry stain was used to demonstrate Helicobacter pylori. Aim of the study is to evaluate the histomorphological patterns of upper gastrointestinal tract disorders on endoscopic biopsy and to correlate various upper gastrointestinal tract disorders in correspondence to clinical parameters. Results: It is reported among 152 cases of UGT biopsies 137 were non-neoplastic lesions and 15 were neoplastic. Commonly affected age group was 31-40 years followed by 41 to 50 years. As per the present study, males were affected more predominantly than females. Out of the 22 cases from esophageal biopsies, 16 cases showed non-neoplastic lesions and 6 were neoplastic. The most common non-neoplastic lesion was chronic nonspecific esophagitis and neoplastic lesion reported was squamous cell carcinoma. Among 113 gastric biopsies, 104 cases were non-neoplastic lesions and 9 were neoplastic lesions. Adenocarcinoma was the predominant neoplastic lesion of stomach. All the 17 duodenal biopsies showed non-neoplastic lesions.

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Histopathological Spectrum of Non-Malignant Lesions of Gastrointestinal Tract- An Institutional Study.

Abstract: Abstract:Background: Gastrointestinal tract (GIT)

Cited by 5 publications

References 8 publications

Histomorphology Spectrum of Gastrointestinal Lesions in A Tertiary Care Centre

Histomorphology Spectrum of Gastrointestinal Lesions in A Tertiary Care Centre

Histopathological spectrum of gastrointestinal lesions - In a tertiary care centre

Evaluating the spectrum of histomorphological patterns on endoscopic biopsy in patients with upper gastrointestinal tract disorders

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