Histopathological study of experimental and natural infections by Trypanosoma cruzi in Didelphis marsupialis

Carreira, João Carlos Araújo; Jansen, Ana Maria; Deane, P U Maria; Lenzi, Henrique Leonel

doi:10.1590/s0074-02761996000500012

Cited by 28 publications

(15 citation statements)

References 21 publications

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“…Experimental infection of marsupials with strains of Lineages 1 and 2 indicates the elimination of type 1 strain from the host, while the type 2 strain promotes a permanent and very mild infection (Carreira et al 1996). In vivo and in vitro experiments suggest that the two lineages differ markedly in infectivity to mammals.…”

Section: Biological Evidencementioning

confidence: 99%

Epidemiology, biochemistry and evolution of Trypanosoma cruzi lineages based on ribosomal RNA sequences

Zingales

Stolf

Souto

et al. 1999

Mem. Inst. Oswaldo Cruz

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Section: Biological Evidencementioning

confidence: 99%

Epidemiology, biochemistry and evolution of Trypanosoma cruzi lineages based on ribosomal RNA sequences

Zingales

Stolf

Souto

et al. 1999

Mem. Inst. Oswaldo Cruz

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“…T. cruzi for example, is a protozoan that causes Chagas disease in humans and is an important contributor to heart disease in Latin America (Kirchhoff, 1996). This parasite is able to infect different marsupial species in America and has been shown to produce inflammatory lesions in tissues similar to those seen in human infections (Barr et al., 1991, Carreira et al., 1996). Furthermore, trypanosomes from the “ T. brucei complex ” are pathogenic trypanosomes from Africa that cause sleeping sickness in humans, and nagana in vertebrate animals.…”

Section: Introductionmentioning

confidence: 99%

In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani : A comparison with Trypanosoma cruzi

Botero

Keatley

Peacock

et al. 2017

International Journal for Parasitology: Drugs and Drug Resistan

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Trypanosomes are blood protozoan parasites that are capable of producing illness in the vertebrate host. Within Australia, several native Trypanosoma species have been described infecting wildlife. However, only Trypanosoma copemani has been associated with pathological lesions in wildlife hosts and more recently has been associated with the drastic decline of the critically endangered woylie (Bettongia penicillata). The impact that some trypanosomes have on the health of the vertebrate host has led to the development of numerous drug compounds that could inhibit the growth or kill the parasite. This study investigated and compared the in vitro susceptibility of two strains of T. copemani (G1 and G2) and one strain of Trypanosoma cruzi (10R26) against drugs that are known to show trypanocidal activity (benznidazole, posaconazole, miltefosine and melarsoprol) and against four lead compounds, two fenarimols and two pyridine derivatives (EPL-BS1937, EPL-BS2391, EPL-BS0967, and EPL-BS1246), that have been developed primarily against T.cruzi. The in vitro cytotoxicity of all drugs against L6 rat myoblast cells was also assessed. Results showed that both strains of T. copemani were more susceptible to all drugs and lead compounds than T. cruzi, with all IC50 values in the low and sub-μM range for both species. Melarsoprol and miltefosine exhibited the highest drug activity against both T. copemani and T. cruzi, but they also showed the highest toxicity in L6 cells. Interestingly, both fenarimol and pyridine derivative compounds were more active against T. copemani and T. cruzi than the reference drugs benznidazole and posaconazole. T. copemani strains exhibited differences in susceptibility to all drugs demonstrating once again considerable differences in their biological behaviour.

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“…In reality, sometimes it is very difficult for the detection of parasites in animals with subpatent infections or symptomless, often requiring specific tests. On the other hand, multiple infections among sylvatic animal hosts involving different parasites species or even different strains from the same species may be very common [46] [47].…”

Section: Discussionmentioning

confidence: 99%

Wild Mammal Translocations: A Public Health Concern

Carreira¹,

Bueno²,

Silva³

2020

OJAS

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With regard to wildlife translocations and the assessment of potential risk of disease transmission, several advances have been made in conservative projects. However, other factors like the large number of species received at screening centers from different locations, rescued after being hit by vehicles, taken by the public or confiscated from illegal trade by the authorities, have increased the risk of spreading, emergence or reemergence of zoonosis. Besides the notorious importance of the procedure improvement for managing wildlife, the access to as much as possible information about the occurrence of potential infections on each particular species can be a tool of great value for mitigating the disease risk. In the present paper, it was showed the evolution of processes for wildlife translocations mostly related to mammals, we also discussed some aspects related to sylvatic animals as reservoir host of zoonosis and finally were presented several tables recording numerous mammals hosts and their respective parasitic protozoa.

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Histopathological study of experimental and natural infections by Trypanosoma cruzi in Didelphis marsupialis

Cited by 28 publications

References 21 publications

Epidemiology, biochemistry and evolution of Trypanosoma cruzi lineages based on ribosomal RNA sequences

Epidemiology, biochemistry and evolution of Trypanosoma cruzi lineages based on ribosomal RNA sequences

In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani : A comparison with Trypanosoma cruzi

Wild Mammal Translocations: A Public Health Concern

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