Histopathological Study of Placental Villi in Pre-Eclampsia-a Quantitative Study

Nafees, Hina; Jain, Shilpi; Khare, Satyam; Khare, Anjali; Kansal, Richa

doi:10.1016/s0003-2778(12)80024-4

Cited by 2 publications

(3 citation statements)

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“…3) It was higher in PIH group compared to control group. Similar results have been observed by Saeed et al, 20 Sharma et al, 21 Pasricha et al, 22 Dhabhai et al 23 and Nafees et al 24 They found higher number of syncytial knots in preeclamptic placenta as compared to control placenta. Khalid et al, 25 Narasimha et al 26 and Tomas et al 27 have also reported the similar findings.…”

Section: Discussionsupporting

confidence: 84%

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A study on histopathological changes in placenta in pre-eclampsia/eclampsia: A case-control study in tertiary care centre, western India

2020

IJPO

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Introduction:In pregnancy induced hypertension (PIH), pathological changes in the placenta occurs which may result in reduced blood flow across placenta. The present study has been undertaken to assess the morphology & histology of placenta from mothers with PIH and to correlate their findings with those of normal pregnancies. Materials and Methods: The present study was a case-control study conducted during July 2015 to September 2017. Placenta of cases of singleton normal pregnancies & those complicated by pre-eclampsia/ eclampsia and of known gestational period were included. The placentae were divided into two groups; Group 1: Pregnancy with hypertension (cases) and Group 2: Normal pregnancy (control). Detailed macroscopic and microscopic examinations were conducted on the placentae. Results:The mean weight of placenta (474 ± 58 grams) was higher among control group in comparison to PIH group (420 ± 61 grams). This difference was statistically significant. (p 0.001) The mean fetoplacental weight ratio (6.14 ± 0.503) was higher among PIH group in comparison to control group (6.03 ± 0.409). This difference was statistically insignificant. (p ˂0.05). There was significant association between presence of gross infarction, calcification, Hyalinised area /10 lpf, medial coat proliferation/ 10 lpf, intervillous hemorrhage, decreased villous vascularity and PIH. Conclusion: It is concluded that there was statistically significant difference between mean birth weight of the babies and mean placental weight in control group and PIH group. It also revealed striking villous lesions like increased syncytial knots, cytotrophoblastic cell proliferation, villous stromal fibrosis and fibrinoid necrosis in placenta from preeclampsia cases.

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Section: Discussionsupporting

confidence: 84%

“…Jones et al 31 found significant increase in number of cytotrophoblast cells in preeclamptic placenta. Narasimha et al, 26 Arnholdt et al, 32 Motwani et a,l 29 Nafees et al, 24 Maqueo et al 33 and also found similar results.…”

Section: Discussionmentioning

confidence: 66%

A study on histopathological changes in placenta in pre-eclampsia/eclampsia: A case-control study in tertiary care centre, western India

2020

IJPO

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“…[10][11][12] Gestational diabetes mellitus results in histopathological abnormalities like syncytial knot formation, fibrinoid necrosis of villi, villous immaturity, and excessive cytotrophoblastic proliferation. 13 The objective was to study the morphological and histopathological variations of the placenta in women with GDM and the effect of these changes on the perinatal outcome.…”

Section: Introductionmentioning

confidence: 99%

Morphological and Histopathological Features of Placenta in Women with Gestational Diabetes Mellitus and Its Association with Perinatal Outcome

Venkatesh,

Shetty,

Chaithra

2024

Journal of South Asian Federation of Obstetrics and Gynaecology

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Background: Placenta, a unique vascular organ, acts as a barrier between maternal and fetal circulation, protecting the fetus from adverse effects of maternal diseases. Gestational diabetes mellitus (GDM) alters the placental function leading to histological and morphological changes in placenta. Hyperglycemia affects placental development leading to adverse maternal and perinatal outcomes. Aim: To understand the morphological and histopathological variations of the placenta in GDM pregnancies and its association with the perinatal outcome. Materials and methods: A hospital-based cross-sectional study was conducted in women with singleton pregnancy between 37 and 40 weeks of gestation with GDM (Cases) and compared with women without GDM (Control). The morphological and histopathological features of the placenta were studied, and the associated perinatal outcome was analyzed. Results: In cases, most of the women had babies with birth weight of 3.51-4 kg (57.1%) and was statistically significant (p = 0.001). The mean placental weight among cases and controls was 719.57 ± 110. 8 gm and 380.71 ± 50.59 gm, respectively. Placental histopathological changes (calcification of the placenta, fibrinoid necrosis of villi and immature villous) were noted in cases and were statistically significant (p = 0.001). Abnormal perinatal outcomes were observed in cases with an oval-shaped placenta (64.7%), increased cord thickness (68.4%), fibrinoid necrosis of villi (50%), syncytial knots (61.9%), and immature villous (54.5%). Conclusion: Gestational diabetes mellitus causes an alteration in morphological and histological features of the placenta resulting in adverse perinatal outcomes. Early diagnosis, treatment, and glycemic control aid in reducing perinatal morbidity and mortality.

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Histopathological Study of Placental Villi in Pre-Eclampsia-a Quantitative Study

Cited by 2 publications

References 5 publications

A study on histopathological changes in placenta in pre-eclampsia/eclampsia: A case-control study in tertiary care centre, western India

A study on histopathological changes in placenta in pre-eclampsia/eclampsia: A case-control study in tertiary care centre, western India

Morphological and Histopathological Features of Placenta in Women with Gestational Diabetes Mellitus and Its Association with Perinatal Outcome

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