Histopathological study of Uterine Leiomyoma in Hysterectomy Specimens

Bhadouria

et al. 2021

IJMBS

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center. Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination. Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases. Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions. Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 98%

Histopathological Study of Benign and Malignant Lesions of Uterus and Cervix in Hysterectomy Specimens

Bhadouria

et al. 2021

IJMBS

J. Bahria Univ. Med. Dent. Coll.

“…The spectrum of benign diseases in hysterectomy specimens include uterine leiomyomas, adenomyosis, endometrial polyps, endometrial hyperplasia, endometritis, disordered proliferative phase endometrium and endometrial stromal nodule. 4,5,6,7 Out of which most frequent pathology encountered is leiomyoma. 3,5,8,9,10 Uterine leiomyoma is defined as benign tumor of smooth muscle origin.…”

Section: Resultsmentioning

confidence: 99%

“…4,5,6,7 Out of which most frequent pathology encountered is leiomyoma. 3,5,8,9,10 Uterine leiomyoma is defined as benign tumor of smooth muscle origin. Incidence of leiomyoma is found to be different according to different studies and it ranges from 20.5-69%.…”

Section: Resultsmentioning

confidence: 99%

“…Incidence of leiomyoma is found to be different according to different studies and it ranges from 20.5-69%. 5,8,9,10,11 It is the commonest benign pathology which leads to menorrhagia, dysmenorrhea, infertility and recurrent abortions in women of reproductive age group. Pathogenesis is unclear but most common risk factors are obesity, insulin resistance, familial tendency, advancing age and hormone therapy.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Frequency and Spectrum of Non-Malignant Lesions in Abdominal Hysterectomy Specimens

Zehra¹,

Gardezi²,

Shams³

et al. 2021

Objective: To determine the histological spectrum of non-malignant lesions in abdominal hysterectomy specimens from women of reproductive age group. Study Design and Setting: This was a descriptive cross-sectional study carried out at a private hospital in Karachi from December 2018 to December 2019. Methodology: The uterine specimens of patients (n=262) between the ages of 24 to 55 years were collected. Hysterectomies done due to any benign uterine disease were included in the study. Hysterectomies due to malignant causes were excluded. Pathological diagnosis was done on light microscopy using routine hematoxylin and eosin staining technique. Data collected during the study period included patient's age, clinical history/diagnosis and histological diagnosis. On receiving the hysterectomy specimens as per protocol, specimens were immediately put in 10% formalin, appropriately labeled for patient’s name, gender, age and procedure. In histopathology lab, grossing of the specimens was done using standard protocols. Frequency and variables were analyzed by using descriptive statistics of SPSS-version 22. Results: Total n=262 hysterectomies were received. Mean age of all the patients was 34.7 years ±7.8. Non-malignant uterine pathologies on histopathology included 124(47.7%) leiomyomas, 52(20%) adenomyosis, 32(12.3%) endometrial polyps, 16(6.2%) endometrial hyperplasia, 6(2.3%) endometritis, 3(1.2%) disordered proliferative endometrium and 1(0.4%) endometrial stromal nodule. Rest of the cases showed normal phases of endometrial cycle. Only two cases (0.76%) out of 262 received as clinically benign uterine disease, were diagnosed as malignant on histopathology. Conclusion: Leiomyoma is the most common uterine pathology diagnosed in clinical setting as well as encountered at histopathological examination followed by Adenomyosis and endometrial polyps in women of reproductive age group in Pakistan.

Clinicopathological features of uterine fibroid in a tertiary care teaching hospital

et al. 2021

Background: Uterine fibroids are one of the common benign tumours of uterus seen in women of reproductive age group. These constitute 5-10% of all these tumours.Methods: Total of 56 patients above 21 years of age reporting to OPD or emergency of gynaecology department of the Mayo Institute and found to be suffering from leiomyoma of the uterus were included in the study.Results: Clinical manifestations seen in cases with uterine fibroid. Menstrual irregularities were seen in 69.64% of cases. 39.28% suffered from abdominal pain and infertility was seen in 10.71% cases. Endometrial changes during the histopathological examination. In 71.42% of cases, proliferative endometrium was found. Secretory endometrium was seen in 14.28% and atrophic in 8.92%. Conclusions: Leiomyoma is the most well-known uterine tumor seen in gynecological practice. Feminine aggravations are the commonest manifestation of which menorrhagia is the most well-known show. The vast majority of these tumors are intramural in area. The most widely recognized example of endometrium noticed is proliferative. Hyaline degeneration, myxoid degeneration and cystic degeneration are the normal auxiliary changes found in fibroid uterus.