Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification.

Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas

“…Seven PTCL-U samples that contained a significant number (more than 30%) of plasma cells and/or B cells were qualified as 'BL'. In all, 10 samples in which reactive histiocytes were numerous and formed significant aggregates were qualified as 'histiocyte rich', including two samples in which atypical T cells were masked by huge amounts of histiocytes, corresponding to the definition of the so-called Lennert's lymphoma (Suchi et al, 1987). The diagnosis of AIL was considered on the basis of usually admitted criteria (Dogan et al, 2003).…”

“…The World Health Organization (WHO) classification recognizes only two well-characterized nodal PTCL entities, namely angioimmunoblastic lymphomas (AIL) and anaplastic large-cell lymphomas (ALCL) (Harris et al, 1994). In fact, although a number of morphological subtypes of PTCL have been described in the past, such as Lennert's lymphoma, T-zone lymphoma, pleomorphic T-cell lymphoma, or T-immunoblastic lymphoma (Suchi et al, 1987), evidence that these correspond to distinct clinicopathological entities is still lacking (Harris et al, 1994;Gisselbrecht et al, 1998). For this reason, the rest of nodal PTCLs are now referred as 'unspecified' (PTCL-U) (Harris et al, 1994).…”

Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas

“…9 • 1994: 'Anaplastic large cell (CD30 + ) lymphoma' was included as a distinct clinicopathological entity in the Revised European-American Classification of Lymphoid Neoplasms (commonly known as REAL classification) which was proposed by the International Lymphoma Study Group. 10 However, while the so-called T and Null cell types were assigned to the ALCL entity, B cell cases were Leukemia included among the morphological variants of 'diffuse large B cell lymphoma'.…”

Linfoma cutâneo de células B: relato de caso

“…O primário é aquele com apresentação cutânea, sem qualquer evidência de lesão extracutânea no momento do diagnóstico e até seis meses após. [5][6][7][8][9] Apesar de serem idênticos na aparência morfológica, possuem comportamentos clínicos diferentes. O primário apresenta história natural mais indolente do que a do secundário, com bom prognóstico, recorrências locais em 25-68% dos casos e rara disseminação extracutânea.…”