Histopathology and pathogenesis of glaucomatous optic neuropathy

Lawrenson, John G

doi:10.1016/b978-0-7506-3782-4.50006-5

Cited by 1 publication

(2 citation statements)

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“…Vascular dysregulation has been proposed to play an important role in POAG and several recent studies have suggested that systemic hypertension is associated with RNFL and GCC thinning, which may represent an important consideration when using retinal SD-OCT measurements as a diagnostic tool . Therefore, in this study, we explored the association between GCC thickness and blood pressure (systolic, diastolic, and mean arterial pressure).…”

Section: Discussionmentioning

confidence: 99%

“…It is well established that older age and higher intraocular pressure (IOP) are risk factors for primary open-angle glaucoma (POAG) . It also has been suggested that factors such as vascular dysregulation and diabetes may play an important role in the development of POAG. In addition, family history is known to contribute to the risk of developing POAG and genetic variants have been identified that play a role in POAG and its endophenotypes …”

Section: Introductionmentioning

confidence: 99%

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Genetic and Environmental Factors Associated With the Ganglion Cell Complex in a Healthy Aging British Cohort

et al. 2017

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IMPORTANCE Measurement of ganglion cell complex (GCC) thickness may be more sensitive than current methods for glaucoma diagnosis and research. However, little is known about the factors influencing GCC thickness in the general population.OBJECTIVES To investigate the heritability of and factors associated with GCC thickness in a healthy aging population. DESIGN, SETTING, AND PARTICIPANTSA cross-sectional twin study was conducted from August 27, 2014, to March 31, 2016, among 1657 participants of white British ancestry from the TwinsUK study cohort without ocular pathologic conditions. Heritability analyses were conducted in 1432 twins (426 monozygous and 290 dizygous pairs). Association analyses were performed using univariable and multivariable stepwise linear regression models, taking family structure into account. Heritability analyses were conducted using maximum likelihood structural equation twin modeling. MAIN OUTCOMES AND MEASURESParameters measured included GCC thickness, autorefraction, intraocular pressure, blood pressure, body mass index, and cholesterol, creatinine, glucose, insulin, triglycerides, and urea levels. Estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease formula. RESULTS Among the 1657 participants (mean [SD] age, 56.0 [15.3] years; 89.5% women and 10.5% men), the mean [SD] inner GCC thickness was 96.0 [7.6] μm (95% CI, 95.1-96.2). In multivariable modeling, the mean inner GCC thickness was associated with advancing age (β, -0.14; P < .001), increased body mass index (β, -0.15; P = .001), spherical equivalent (β, 0.70; P < .001), and higher estimated glomerular filtration rate (β, 0.03; P = .02). A 1-U increase in age or body mass index was associated with a 0.14-μm and 0.15-μm decrease in GCC thickness, respectively (P < .001), while a 1-U increase in spherical equivalent or estimated glomerular filtration rate was associated with a 0.70-μm (P < .001) and 0.03-μm (P = .02) increase in GCC thickness, respectively. Ganglion cell complex thickness was not associated with sex, intraocular pressure, or diabetes. Age-adjusted GCC thickness was highly heritable, with additive genetic effects explaining 81% (95% CI, 78%-84%) of phenotypic variance and individual environmental factors explaining the remaining 19% (95% CI, 16%-22%).CONCLUSIONS AND RELEVANCE Ganglion cell complex thickness appears to be highly heritable and further genetic analysis may help identify new biological pathways for glaucoma. The results suggest it may be important to account for age, body mass index, refractive error, and sex when using GCC thickness as a diagnostic tool. Replication of their results is required, as is further research to explain the association between renal function and GCC thickness.

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Section: Discussionmentioning

confidence: 99%