Histopathology of endocrine mucin-producing sweat gland carcinoma of the eyelid

Bamberger, Mark; Medline, Paul B.; Cullen, Jim; Gill, Hartej

doi:10.1016/j.jcjo.2015.12.008

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…Once the mass is deemed a primary skin adnexal tumor, the differential diagnosis for EMPSGC includes basal cell carcinoma (nodular subtype), nodular hidradenoma, hidradenocarcinoma, hidrocystoma, apocrine tubular adenoma, monomorphic adenoma, and dermal duct tumor [1, 2, 6, 8]. …”

Section: Discussionmentioning

confidence: 99%

“…It is therefore pertinent that a comprehensive physical exam with imaging is completed to rule out a primary breast lesion with metastases. When considering EMPSGC, the differential diagnosis also includes other skin tumors especially nodular basal cell carcinoma, nodular hidradenoma, hidradenocarcinoma, hidrocystoma, apocrine tubular adenoma, monomorphic adenoma, and dermal duct tumors [1, 2, 6, 8]. If a tumor has a lobular architecture with solid, papillary, and/or cribriform areas, evidence of neuroendocrine differentiation, and mucin production, EMPSGC should be considered.…”

Section: Discussionmentioning

confidence: 99%

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Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge

Brett

Salama

Gohla

et al. 2017

Case Reports in Pathology

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Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare adnexal tumor of the skin with low-grade cytological features and neuroendocrine differentiation. It has a predilection for the skin of the eyelid, but has also been reported in the face and rarely extra-facial locations. The tumor is seen more frequently in women and on average affects the elderly. It is histologically and immunohistochemically analogous to solid papillary carcinoma of the breast/endocrine ductal carcinoma in situ with a nodular, solid, papillary, and/or cribriforming architecture, neuroendocrine differentiation, and mucin production. Since it was first described by Flieder et al. in 1997, less than 60 cases have been reported in literature. We describe the morphological and immunohistochemical features of another case with a review of the common histological differential diagnoses and emphasize the salient features that help distinguish this rare neoplasm.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge

Brett

Salama

Gohla

et al. 2017

Case Reports in Pathology

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“…Importantly, however, EMPSGC shows substantial histomorphologic overlap with metastatic adenocarcinoma, which must carefully be excluded by evaluation of both the histomorphology and immunophenotype. 5,6 EMPSGC is described as a circumscribed or multilobulated dermal tumor showing solid, cribriform, cystic, and or papillary architecture. Mucin is present both intracellularly and extracellularly, and its bland, monomorphous nuclei possess inconspicuous nucleoli, occasionally stippled chromatin, and generally sparse mitotic figures.…”

Section: Introductionmentioning

confidence: 99%

Comparative performance of insulinoma‐associated protein 1 (INSM1) and routine immunohistochemical markers of neuroendocrine differentiation in the diagnosis of endocrine mucin‐producing sweat gland carcinoma

et al. 2020

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Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal malignancy with predilection for the eyelids of older adults. It must be distinguished from metastatic adenocarcinomas of extracutaneous origin and from benign adnexal proliferations on partial samples when a solid growth component and mucin production are not evident. Thus, demonstration of neuroendocrine differentiation can help to ensure a correct diagnosis. Insulinoma-associated protein 1 (INSM1) is a novel neuroendocrine marker that has recently shown greater sensitivity than synaptophysin (SYN) and chromogranin (CHR) in the diagnosis of various neuroendocrine neoplasms. We compared the performance of these three markers across 10 examples of EMPSGC. All EMPSGCs expressed INSM1. Eight of ten were also immunoreactive for SYN; however, INSM1 staining was generally more intense and stained a greater proportion of the tumor cells. CHR staining was weak and focal in most cases. INSM1 staining was present in hidrocystoma-like components of cystic EMPSGC. These findings suggest that INSM1 may be more sensitive than SYN and CHR and thus valuable for establishing a diagnosis of EMPSGC.

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“…Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare low‐grade primary cutaneous sweat gland carcinoma with predilection for the periorbital skin in elderly female patients. Around 70 cases of EMPSGC have been reported so far (Table ). The tumor exhibits morphologic and immunophenotypical similarity to endocrine ductal carcinoma in situ (DCIS) or solid papillary carcinoma of the breast .…”

Section: Introductionmentioning

confidence: 99%