Histopathology of important fungal infections – A summary

Ghosh, Arnab; Magar, Dilasma Gharti; Thapa, Sushma; Nayak, Niranjan; Talwar, OP

doi:10.3126/jpn.v9i1.23377

Cited by 11 publications

(10 citation statements)

References 23 publications

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“… 27 The success rates in the management of mucormycosis have ranged between 20% and 70% depending on the time lapse from presentation to diagnosis, the aggressive nature of the disease, and the immunocompromised state of the affected patients. A biopsy of sample from clinically affected sites and demonstration of hyphae by direct microscopy are crucial for diagnosis 13 , 28 , 29 and to define and re-evaluate the treatment response. The presence of viable tissue along with necrotic tissue will confirm that a good debridement was performed.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India

et al. 2022

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Background: An upsurge in cases of rhinosinusitis with or without associated orbital and/or cerebral involvement by mucormycosis has been observed in post-COVID-19 patients. Our objective is to evaluate the clinical and histopathology features of these patients to determine the severity and develop a scoring on the extent on tissue invasion. Method: We prospectively enrolled and analyzed 95 post-COVID-19 patients who presented with the invasive mucormycosis of the head and neck region. Clinical and histology details were noted in predesigned forms. Various histology variables were graded from I to III to propose a scoring system for the severity of the disease. Results: Mucormycosis was common in males with a mean age of 46.8 ± 11 years. Facial pain was the most common presenting complaint and 77% of the patients were diabetic. Most cases (n = 59) showed a moderate degree of neutrophilic infiltrate with ⩾50% tissue necrosis and angioinvasion in three or more vessels with a fungal load of 2+/3+. Histology severity grade III was observed in patients who died from cerebral mucormycosis (n = 3) and septicemia (n = 2) and in patients who had undergone orbital exenteration (n = 6). Conclusion: The histopathology and severity score classification was directly correlated with the outcome of the patients. Further evaluation and a larger study will help to validate the proposed scoring for its clinical use in all forms and causes of mucormycosis.

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Section: Discussionmentioning

confidence: 99%

Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India

et al. 2022

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“…In large specimens, grossing and biting may not be representative, or organisms may be present in the deeper plane and could have been identified on viewing deeper sections. Tissue reactions can be considered a soft sign to suspect fungal infections such as necrosis, histiocytes and lymphocytes, eosinophil aggregates, giant cells, and sometimes neutrophil clumps [ 11 ]. Tissue response is variable and based on allergic, acute, or chronic infection [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Direct Examination, Culture, and Histopathology in the Diagnosis of Mucormycosis: Reiterating the Role of KOH Mount for Early Diagnosis

Mohanty¹,

Gupta²,

Kunnumbrath³

et al. 2021

Cureus

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Introduction Invasive fungal infections have always been a major cause of mortality and morbidity and are especially prevalent in the immunosuppressed groups of patients. Members of the Mucoracea family have an increasing incidence and prevalence. It has always been difficult to diagnose this condition due to various reasons. Materials and Methods This was an observational study carried out jointly by the Department of Microbiology and the Department of Pathology for a duration of one year. All patients who presented in various clinical departments with a high index of clinical suspicion for mucormycosis were included in this study. A total of 186 samples were received from suspected cases of mucormycosis and were all subjected to direct microscopy by potassium hydroxide (KOH), fungal culture, and histopathological examination. Results Mucormycosis was documented in 33 out of 186 cases on direct microscopy, whereas 21 were positive on fungal culture. Histopathological positivity was reduced with only 11 cases showing aseptate hyphae suggestive of mucormycosis. Conclusion As these organisms generally do not grow well on routine culture media and with the histopathological results also being not suggestive clearly of mucormycosis, direct microscopy thus becomes more important and essential in the rapid diagnosis of this deadly condition.

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“…Histopathologic examinations are often specific enough to yield an accurate diagnosis on which treatment can be based. 6 However, microbial cultures of aspergillosis are necessary for confirming the diagnosis and determining the species. 7 In this case report, the diagnosis was determined by histopathological examination using special staining with PAS, GMS, and ZN.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Maxillary Aspergillosis with Unusual Clinical and Imaging Presentations

Jan

Jadu

2020

The Journal of Contemporary Dental Practice

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Aim:The aim of the present study was to present a case of maxillary aspergillosis with unusual clinical presentation and imaging findings. Background: The range of lesions and conditions that affect the maxillary sinus is wide and vast. This necessitates a dynamic multidisciplinary approach for proper diagnosis and effective management. Case description: We present an unusual case of maxillary aspergillosis that mimicked apical periodontitis and was most consistent with lymphoma from the diagnostic imaging perspective. Histopathology, however, established the correct diagnosis; appropriate management commenced promptly. Conclusion: It is imperative that maxillary aspergillosis be diagnosed and managed properly and promptly to improve prognosis. Advanced imaging is required, but it plays an adjunct role to histopathology. Long-term follow-up is also necessary to ensure complete resolution of the infection. Clinical significance: Correlating clinical and imaging findings is a crucial step and any inconsistencies should be resolved promptly so as not to delay adequate management. Histopathology often serves to dispute any inconsistencies and allows the establishment of a proper diagnosis.

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Histopathology of important fungal infections – A summary

Cited by 11 publications

References 23 publications

Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India

Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India

Evaluation of Direct Examination, Culture, and Histopathology in the Diagnosis of Mucormycosis: Reiterating the Role of KOH Mount for Early Diagnosis

A Case Report of Maxillary Aspergillosis with Unusual Clinical and Imaging Presentations

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