Histopathology of Middle East respiratory syndrome coronovirus (<scp>MERS</scp>‐CoV) infection – clinicopathological and ultrastructural study

Alsaad, Khaled O.; Hajeer, Ali H.; Balwi, Mohammed Al; Moaiqel, Mohammed Al; Oudah, Nourah Al; Ajlan, Abdulaziz Al; Aljohani, Sameera; Alsolamy, Sami; Gmati, Giamal; Balkhy, Hanan H.; Al-Jahdali, Hamdan; Baharoon, Salim; Arabi, Yaseen M.

doi:10.1111/his.13379

Cited by 278 publications

(290 citation statements)

References 18 publications

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“…Due to the small number of autopsies on patients with MERS, detection of pathological basis was limited. Diffuse alveolar damage was also found in the lungs in two autopsies, including damage to alveolar epithelial cells, multinuclear epithelial cells, and submucosal glands (12,13). In the animal model of MERS, consolidation, edema, and inflammation can be found in the infected lungs, and diffuse alveolar injury with hyaline membrane formation can also be observed (14À16).…”

Section: Discussionmentioning

confidence: 99%

Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT

Guan¹,

Lv²,

et al. 2020

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Rationale and Objectives: To retrospectively analyze the chest imaging findings in patients with coronavirus disease 2019 (COVID-19) on thin-section CT.Materials and Methods: Fifty-three patients with confirmed COVID-19 infection underwent thin-section CT examination. Two chest radiologists independently evaluated the imaging in terms of distribution, ground-glass opacity (GGO), consolidation, air bronchogram, stripe, enlarged mediastinal lymph node, and pleural effusion.Results: Fourty-seven cases (88.7%) had findings of COVID-19 infection, and the other six (11.3%) were normal. Among the 47 cases, 78.7% involved both lungs, and 93.6% had peripheral infiltrates distributed along the subpleural area. All cases showed GGO, 59.6% of which were round and 40.4% patchy. Other imaging features included "crazy-paving pattern" (89.4%), consolidation (63.8%), and air bronchogram (76.6%). Air bronchograms were observed within GGO (61.7%) and consolidation (70.3%). Neither enlarged mediastinal lymph nodes nor pleural effusion were present. Thirty-three patients (62.3%) were followed an average interval of 6.2 § 2.9 days. The lesions increased in 75.8% and resorbed in 24.2% of patients.Conclusion: COVID-19 showed the pulmonary lesions in patients infected with COVID-19 were predominantly distributed peripherally in the subpleural area.

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Section: Discussionmentioning

confidence: 99%

Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT

Guan¹,

Lv²,

et al. 2020

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“…Therefore, there are few data on the histopathological changes in patients with MERS-CoV infection, even in severe disease. 46,47 The only two autopsies available show that viral infection was confined predominantly to the respiratory tract, although viral particles were detected in the kidney in one of the reports. 47 Further, ex vivo human kidney cultures were shown to support productive MERS-CoV infection.…”

Section: Pathogenesis and Pathologymentioning

confidence: 99%

Middle East respiratory syndrome

et al. 2020

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The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.

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“…Viral inclusions were identified by electron microscopy not only in the respiratory epithelium but also the epithelial cells of the renal proximal tubules. 30 Also reported in the literature is a case of a man who 8 weeks following infection with MERS-CoV underwent renal biopsy. Histology demonstrated acute tubular sclerosis with proteinaceous cast formation, acute tubulointerstitial nephritis, and no glomerulosclerosis.…”

Section: Histopathologic Featuresmentioning

confidence: 99%

Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella

Bradley

Bryan

2019

Seminars in Diagnostic Pathology

112

126

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A B S T R A C TLower respiratory infections remain one of the top global causes of death and the emergence of new diseases continues to be a concern. In the first two decades of the 21st century, we have born witness to the emergence of newly recognized coronaviruses that have rapidly spread around the globe, including severe acute respiratory syndrome virus (SARS) and Middle Eastern respiratory syndrome virus (MERS). We have also experienced the emergence of a novel H1N1 pandemic influenza strain in 2009 that caused substantial morbidity and mortality around the world and has transitioned into a seasonal strain. Although we perhaps most frequently think of viruses when discussing emerging respiratory infections, bacteria have not been left out of the mix, as we have witnessed an increase in the number of infections from Legionella spp. since the organisms' initial discovery in 1976. Here, we explore the basic epidemiology, clinical presentation, histopathology, and clinical laboratory diagnosis of these four pathogens and emphasize themes in humans' evolving relationship with our natural environment that have contributed to the infectious burden. Histology alone is rarely diagnostic for these infections, but has been crucial to bettering our understanding of these diseases. Together, we rely on the diagnostic acumen of pathologists to identify the clinicopathologic features that raise the suspicion of these diseases and lead to the early control of the spread in our populations. (A. Bryan). Seminars in DiagnosticPathology 36 (2019) 152-159 0740-2570/

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Histopathology of Middle East respiratory syndrome coronovirus (MERS‐CoV) infection – clinicopathological and ultrastructural study

Abstract: The results highlight the pulmonary and extrapulmonary pathological changes of MERS-CoV infection and provide the first evidence of the viral presence in human renal tissue, which suggests tissue trophism for MERS-CoV in kidney.

Cited by 278 publications

References 18 publications

Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT

Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT

Middle East respiratory syndrome

Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella

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