Histopathology of morphea: Sensitivity of various named signs, a retrospective study

Jindal, Rashmi; Shirazi, Nadia; Chauhan, Payal

doi:10.4103/ijpm.ijpm_67_20

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…An interesting finding shared by GA and morphea is that both exhibit alterations in collagen and CD34 loss 2,14,6 . It has been proposed that the collagen degeneration seen in GA is mediated by M1 macrophages, a type of macrophage that initiates inflammation 15 .…”

Section: Discussionmentioning

confidence: 99%

Patch-Type Granuloma Annulare with Clinical and Histological Features of Morphea: A True Overlap?

et al. 2023

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A 67-year-old woman was evaluated for a worsening asymptomatic rash located on her torso, back, and legs. She denied any chills or fevers, and reported feeling otherwise well. Clinically, large brownish, slightly atrophic plaques were seen on the torso suggestive of either morphea or a granulomatous condition. Histopathologic examination revealed an increase in interstitial histiocytes infiltrating between altered collagen fibers, palisaded granulomas with increased mucin, suggestive of granuloma annulare (GA), as well as dermal sclerosis, perineural infiltrates with plasma cells and diminished CD34 counts, that are more typical for localized scleroderma/morphea. Morphea and patch-type GA may be indistinguishable clinically and share some histopathological features. This case demonstrates similarities between these conditions and features of both conditions in the same patient.

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Section: Discussionmentioning

confidence: 99%

Patch-Type Granuloma Annulare with Clinical and Histological Features of Morphea: A True Overlap?

et al. 2023

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“…This entity presents with dense dermal collagen bundles on histopathology, along with sclerosis, fibrosis, and atrophy to the subcutaneous tissue. 8 Lichen planus pigmentosus is a rare condition of unknown cause that is characterized by macular pigmentation in sun-exposed areas. Pathologic findings include hyperkeratosis, atrophic epidermis with vacuolar degeneration, and lichenoid infiltrates of the dermis with melanin incontinence.…”

Section: Discussionmentioning

confidence: 99%

“…This entity presents with dense dermal collagen bundles on histopathology, along with sclerosis, fibrosis, and atrophy to the subcutaneous tissue. 8…”

Section: Discussionmentioning

confidence: 99%

Persistent Hyperpigmented Macules on the Scalp and Face: Answer

Sadeghi,

Ziemer,

et al. 2024

The American Journal of Dermatopathology

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“…These include the square biopsy sign, cookie cutter sign, high eccrine glands, and the line sign (LS). [4][5][6] Alterations in the appearances of H&E-stained dermal collagen have been long recognized as diagnostically useful in dermatopathology. 7 Beyond the definitional collagen alteration associated with keloids, among the most distinctive and best known diagnostic clues is the free-floating collagen (sometimes described as collagen balls, collagen trapping) associated with dermatofibroma (benign fibrous histiocytoma).…”

Section: Introductionmentioning

confidence: 99%

“…Simple, rapidly assessed diagnostic clues for fully evolved morphea that can be assessed at scanning magnification have been well described. These include the square biopsy sign, cookie cutter sign, high eccrine glands, and the line sign (LS) 4–6 …”

Section: Introductionmentioning

confidence: 99%

The Free Sign in morphea and other sclerosing disorders: A clue to the presence of early sclerosis?

et al. 2023

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BackgroundThe Floating Sign is a histopathologic clue to the diagnosis of autoimmune sclerosing skin disorders such as morphea and interstitial granulomatous dermatitis (IGD). On the other hand, the “free‐floating” sign has been associated with neoplasms, for example, dermatofibroma and interstitial mycosis fungoides. Herein, we report the Free Sign in sclerosing skin disorders.MethodsIn a case‐control study, we applied detailed histopathologic definitions of Floating Sign and Free Sign to assess their presence in morphea, IGD, and other sclerosing disorders.ResultsFree Sign was present in most cases of morphea (46/55, 84%) and IGD (7/13, 54%) but not necrobiosis lipoidica (NL) (6/14, 42.8%) or sclerodermoid graft versus host disease (SGVHD) (2/7, 28.5%). The sensitivity and specificity of Free Sign for morphea versus other disorders was 84% and 56%, respectively. Floating Sign was not identified in most cases: NL (3/14, 21.4%), SGVHD (1/7, 14.2%), morphea (5/55, 9%), IGD (1/13, 7.7%). The diagnostic sensitivity of Floating Sign in morphea was 9%.ConclusionsThe Free Sign was present in most cases of morphea in our series and may represent a clue to the presence of evolving sclerosis. Free Sign may be seen in other sclerosing disorders. Technical artifact is a potential cause of a false‐positive Free Sign.

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Histopathology of morphea: Sensitivity of various named signs, a retrospective study

Cited by 5 publications

References 5 publications

Patch-Type Granuloma Annulare with Clinical and Histological Features of Morphea: A True Overlap?

Patch-Type Granuloma Annulare with Clinical and Histological Features of Morphea: A True Overlap?

Persistent Hyperpigmented Macules on the Scalp and Face: Answer

The Free Sign in morphea and other sclerosing disorders: A clue to the presence of early sclerosis?

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