Histopathology of Neovascularisation Observed During Saphenofemoral Re-Do High Ligation

Ehrler, Michaela; Heim, Dominik; Mouton, Wolfgang G.

doi:10.1016/j.ejvsvf.2021.06.005

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Of the four causes of RVV described, neovascularisation is the mechanism most recently involved in the pathogeny of RVV. This is revealed by eco-Doppler [8], quantified by 3D reconstruction images [16], and confirmed by the histopathological analysis of surgical parts [17]. Neovascularisation is a common cause of post-surgical RVV, with the use of eco-Doppler revealing it accounts for 25-94% of these cases [7,8].…”

Section: Discussionmentioning

confidence: 65%

Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins

Sánchez

Martínez

Méndez-García

et al. 2022

JPM

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Background: Surgery on varicose veins (crossectomy and stripping) may lead to recurrence, with clinical and socioeconomic repercussions. The etiopathogenesis of varicose veins has yet to be fully understood. Objective: Study the expression of endoglin and other molecules involved in the neovascularisation process in patients suffering from this disease. Methods: Total of 43 patients that have undergone surgery for varicose veins (24 primary and 19 recurrent). Endoglin and other molecules were identified on the venous wall (proximal -saphenofemoral junction- and distal), via real-time RT-PCR, and in serum, via ELISA: endoglin (Eng), vascular endothelial growth factor (VEGF-A), its receptors 1 and 2 (VEGFR1 or FLT1), (VEGFR2 or FLK), and the hypoxia-inducible factor (HIF-1A). All the patients signed a consent form. Results: The recurrent group recorded a higher expression of Eng, VEGF-A, VEGFR1, and VEGFR2 at the level of proximal venous wall compared to the primary group. HIF-1A did not record any differences. As regards the determination of the distal venous wall, no markers recorded differences between the groups. Among the serum determinations, only sFLT1 recorded a significant drop among the patients with recurrent varicose veins. Conclusions: Patients with recurrent varicose veins record a higher expression of endoglin and other markers of angiogenesis in proximal veins. Endoglin in the blood (sEng) serves no apparent purpose in recurrent varicose veins.

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Section: Discussionmentioning

confidence: 65%

Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins

Sánchez

Martínez

Méndez-García

et al. 2022

JPM

View full text Add to dashboard Cite

show abstract

“…Out of the four causes of RVV described, neovascularisation is the mechanism most recently involved in the pathogeny of RVV. This may be revealed by eco-Doppler [8], quantified by 3D reconstruction images [16], and confirmed by the histopathological analysis of surgical parts [17]. Neovascularisation is a common cause of post-surgical varicose recurrence; the use of eco-Doppler reveals it accounts for 25-94% of RVV [7][8].…”

Section: Discussionmentioning

confidence: 75%

Endoglin and Other Angiogenesis Markers on Recurrent Varicose Veins

Sánchez¹,

Martínez²,

García³

et al. 2022

Preprint

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Background: Surgery on varicose veins (crossectomy and stripping) leads to recurrence and has clinical and socio-economic repercussions. Their etiopathogenesis has yet to fully under-stood. Objective: Study the expression of endoglin and other molecules involved in the neovascu-larisation process in patients suffering from this disease. Methods: 43 patients that have undergone surgery for varicose veins (24 primary and 19 recurrent). They were identified on the venous wall (proximal -saphenofemoral junction- and distal), via real-time RT-PCR, and in serum, via ELISA: Endoglin (Eng), Vascular Endothelial Growth Factor (VEGF-A), its receptors 1 and 2 (VEGFR1 or FLT1), (VEGFR2 or FLK), and the Hypoxia-Inducible Factor (HIF-1A). All the patients signed a con-sent form. Results: The recurrent group recorded a higher expression of Eng, VEGF-A, VEGFR1 and VEGFR2 at the level of proximal venous wall compared to the primary group. HIF-1A did not record any differences. As regards the determination of the distal venous wall, no markers recorded differ-ences between the groups. Among the serum determinations, only sFLT1 recorded a significant drop among the patients with recurrent varicose veins. Conclusions: Patients with recurrent vari-cose veins record a higher expression of endoglin and other markers of angiogenesis in proximal veins. Endoglin in the blood (sEng) has not proven to be of any use in recurrent varicose veins.

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The sonographic features of lymph node venous networks and flow patterns in patients with primary chronic venous disease

Liu,

Clarke,

Liu

et al. 2024

Phlebology

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Background Our study aims to enhance the understanding of lymph node venous networks (LNVNs) by summarising their anatomical, sonographic features, and reflux patterns. Method We examined 241 legs from 141 patients with primary chronic venous disease (CVD) using duplex ultrasound. Results The findings indicated variations in the shape, size, vascularity, and echogenicity of LNVN. The superficial inguinal lymph node with reflux appeared slightly larger, exhibiting higher velocities in the hilar artery. Regarding connections, venous flow within LNVN was predominantly drained through the saphenofemoral junction (SFJ), anterior accessory great saphenous vein (AAGSV), and great saphenous vein (GSV). A significant number of LNVNs were observed to be associated with anterolateral thigh tributaries. The study also identified valve cusps within LNVN. Conclusion This study revealed a 12% prevalence of primary LNVN. Understanding the anatomical and haemodynamic features of LNVN informs treatment strategies and potentially helps prevent the recurrence of varicose veins.

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Histopathology of Neovascularisation Observed During Saphenofemoral Re-Do High Ligation

Cited by 3 publications

References 8 publications

Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins

Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins

Endoglin and Other Angiogenesis Markers on Recurrent Varicose Veins

The sonographic features of lymph node venous networks and flow patterns in patients with primary chronic venous disease

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