Histopathology of non-coeliac gluten sensitivity

Kirmizi, Ayca; Salman, Fadime Gul; Savaş, Berna; Kalkan, Cagdas; Soykan, İrfan; Ensarı, Arzu

doi:10.1007/s00428-021-03257-5

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…Recently, Kirmizi et al ( 170 ) analyzed duodenal mucosae of 44 NCGS patients, reporting preserved villous architecture, normal or mildly increased intraepithelial lymphocytes (IELs) with clusters, with normal count of eosinophils and mast cells. They proposed the irregular distribution of IELs with clusters in the villous epithelium as an histological finding supporting the diagnosis of NCGS, but larger studies are needed to confirm their results.…”

Section: Non-coeliac Gluten Sensitivitymentioning

confidence: 99%

Skin gluten-related disorders: new and old cutaneous manifestations to be considered

et al. 2023

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The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.

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Section: Non-coeliac Gluten Sensitivitymentioning

confidence: 99%