Histopathology of skin lesions in renal allograft recipients—an assessment of viral features and dysplasia

Blessing, K.; McLaren, K M; Benton, E. C.; Barr, B. B.; Bunney, Mary H.; Smith, I. P.; Beveridge, G. W.

doi:10.1111/j.1365-2559.1989.tb02123.x

Cited by 75 publications

(36 citation statements)

References 27 publications

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“…which arc thought to have a pathogenetic role [ 14], None of the initial diag nostic biopsies showed any stigmata of HPV infection or discernible dysplasia in the presence of lichen planus. It is interesting that the squamous cell carcinomas themselves showed variable hypergranulosis, development of colloid bodies, clefting at the tumour/stromal interface and a sur rounding 'lichenoid' infiltrate.…”

Section: Discussionmentioning

confidence: 95%

Squamous Cell Carcinoma Complicating Lichen planus: A Clinico-Pathological Study of Three Cases

Gawkrodger

Stephenson²,

Thomas³

1994

Dermatology

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Squamous cell carcinoma complicating lichen planus is described in 3 patients. In 2, the cancers developed on the lower leg in chronic and hypertrophic lichen planus. In the other case, the cancer complicated lichen planus of the lip mucosa in a smoker. In the two cutaneous cases, the tumour and the adjacent skin showed features of lichen planus, including hypergranulosis, cytoid bodies and a lichenoid infiltrate. The association, though rare with cutaneous lichen planus when it tends to affect chronic hypertrophic lesions on the lower legs, is now well recognized with oral lichen planus. Patients with oral involvement warrant long-term follow-up, especially if they have other risk factors such as smoking or excessive ultraviolet exposure. Chronicity of lichen planus at other skin sites may also be a risk factor.

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Section: Discussionmentioning

confidence: 95%

Squamous Cell Carcinoma Complicating Lichen planus: A Clinico-Pathological Study of Three Cases

Gawkrodger

Stephenson²,

Thomas³

1994

Dermatology

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“…dot blot in the largest series of 77 patients [4,14], in situ hybridiza tion on frozen sections [ 15]; however, all the experiments show that the copy number of HPV type 5 DNA is rel atively low. In contrast, in EV patients 300-600 copies could be detected [1].…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Human Papillomavirus Type 5 on Frozen Sections of Multiple Lesions from Transplant Recipients with in situ Hybridization and Non-lsotopic Probes

et al. 1992

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Transplant recipients are at high risk to develop multiple cutaneous lesions after grafting. The frequency of the potentially oncogenic human papillomavirus (HPV) type 5 DNA was evaluated in cutaneous lesions taken from sun-exposed areas in transplant recipients (92 lesions and 5 samples from normal skin) and compared with a nontransplanted population (22 lesions and 7 samples from normal skin) using in situ hybridization and biotinylated probes to HPV types 1 2, 5, 16 and 18. HPV type 5 DNA was identified in 8/92 cutaneous lesions of transplanted recipients: 3 warts, 1 case of seborrheic keratosis, 2 actinic keratoses and 2 keratoacanthomas. HPV type 5 DNA was not detected in 27 malignant tumors (8 basal cell carcinomas and 19 squamous cell carcinomas) from transplant recipients. HPV DNA type 5 was detected in only 1 case of squamous cell carcinoma from the general population. The presence of HPV DNA 5 was confirmed with Southern blotting in 2 out of 6 cases from transplant recipients. The reaction was negative with the squamous cell carcinoma from nontransplant recipients. These data indicate that the presence of HPV DNA type 5 is not very frequent; it can be detected with in situ hybridization and nonisotopic probe, which is easier to handle than Southern blot.

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“…By contrast, investigation of the relationship between HPV and cutaneous cancers in RARs has been inconclusive with regard to both prevalence and type of HPV DNA detected. This may be the result of differences in sample size studied or differences in sensitivity and specificity of the detection (Lutzner et al, 1980(Lutzner et al, , 1983Rudlinger et al, 1986;Jablonska et al, 1987;Van der Leest, 1987;Blessing et al, 1989;Euvrard et al, 1991). An additional factor in some studies may be the inclusion of a large proportion of patients who seem to be at exceptionally high risk of developing multiple and widespread premalignant and malignant cutaneous lesions with increased HPV DNA content .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumour promotion

Stark

Arends²,

McLaren³

et al. 1994

Br J Cancer

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Summary It is well established that renal allograpft recipients (RARs) have an increased incidence of viral warts and premalignant and malignant cutaneous lesions, and the risk of their development increases in proportion to duration of graft survival. It has been postulated that, in addition to the effects of prolonged immunosuppression and previous sun exposure, human papillomaviruses (HPV) may also contribute to the carcinogenic process. In this study, the prevalence of HPV DNA was examined in a range of premalignant and malignant cutaneous tumours from 50 immunosuppressed patients (47 renal allograft recipients plus three cardiac allograft recipients) and 56 immunocompetent patients using Southern hybridisation as a lowstringency screening method and type-specific polymerase chain reaction (PCR) assays for eight HPV types. The combined results for renal allograft recipients show that HPV DNA was detectable in 79% of viral warts, 42% of premalignant keratoses, 33% of intraepidermal carcinomas, 43% of invasive squamous cell carcinomas and 16% of uninvolved skin specimens (squamous cell carcinomas/renal allograft recipients significantly different at P <0.05 from uninvolved skin specimens/renal allograft recipients). In immunocompetent patients the pattern of HPV DNA prevalence was 100% for viral warts; 25% for keratoses, 23% for intraepidermal carcinomas, 22% for squamous cell carcinomas and 8% for uninvolved skin. No single HPV type predominated in tumour specimens from either group. More tumours were found to contain HPV DNA by Southern hybridisation analysis than PCR, indicating the presence of HPV types other than HPV 1, 2, 5, 6, 8, 11, 16 and 18 in some tumours. However, 'low cancer risk' HPV types 1, 2 and 6 as well as 'high cancer risk' HPV types 5 and 16 were specifically detected by PCR in a small number of neoplasms. These data suggest that multiple HPV types may contribute to cutaneous neoplasia in RARs and that they appear to act early in the process of carcinogenesis, perhaps by functioning as tumour promoters via stimulation of cell proliferation.

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Histopathology of skin lesions in renal allograft recipients—an assessment of viral features and dysplasia

Cited by 75 publications

References 27 publications

Squamous Cell Carcinoma Complicating Lichen planus: A Clinico-Pathological Study of Three Cases

Squamous Cell Carcinoma Complicating Lichen planus: A Clinico-Pathological Study of Three Cases

Evaluation of Human Papillomavirus Type 5 on Frozen Sections of Multiple Lesions from Transplant Recipients with in situ Hybridization and Non-lsotopic Probes

Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumour promotion

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