Histopathology of spontaneous periodontitis in dogs

Hamp, Sven‐Erik; Lindberg, R.

doi:10.1111/j.1600-0765.1977.tb00108.x

Cited by 40 publications

(19 citation statements)

References 17 publications

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“…12,43 In the present study, the sequential dental radiographs confirmed previously reported changes secondary to periodontal disease. These findings are in agreement with the findings of previous studies, 44,45,47,48 although other studies contradict any association. 45 The early furcation involvement in dogs compared with humans may be related to the proximity of the gingival sulcus to the furcation.…”

Section: Discussionsupporting

confidence: 94%

“…45 The early furcation involvement in dogs compared with humans may be related to the proximity of the gingival sulcus to the furcation. 33,36,44,46,47,51 Histometric analyses and histopathology reported in this study were similar to results reported in Beagle dogs in other studies. These findings are in agreement with the findings of previous studies, 44,45,47,48 although other studies contradict any association.…”

Section: Discussionsupporting

confidence: 90%

“…These findings concur with findings from previous similar studies. [33][34][35][36][44][45][46] Clinical signs of plaque, calculus, mobility, pocket depth, and furcation pathology were positively associated with radiographic changes. This observation may be related to the narrow width of the gingiva at 105-107 in the dog and also to the close proximity of the zygomatic and parotid salivary ducts, depositing saliva that enhances calculus formation.…”

Section: Discussionmentioning

confidence: 99%

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Repair of Experimental Plaque-Induced Periodontal Disease in Dogs

et al. 2007

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Forty mongrel dogs were used in this study for induction of periodontal disease by placing subgingival silk ligatures affecting maxillary and mandibular premolar teeth during a 12-month period. Experimental premolar teeth received monthly clinical, radiographic, and histometric/pathologic assessments. The results demonstrated significant increases in scores and values of periodontal disease parameters associated with variable degrees of alveolar bone loss. The experimental maxillary premolar teeth exhibited more severe and rapid rates of periodontal disease compared with mandibular premolar teeth. Histometric analysis showed significant reduction in free and attached gingiva of the experimental teeth. Histopathological examination of buccolingual sections from experimental premolar teeth showed the presence of rete pegs within the sulcular epithelium with acanthosis and erosive changes, widening of the periodontal ligament, and alveolar bone resorption. Various methods for periodontal repair were studied in 194 experimental premolar teeth exhibiting different degrees of periodontal disease. The treatment plan comprised non-surgical (teeth scaling, root planing, and oral hygiene) and surgical methods (closed gingival curettage, modified Widman flap, and reconstructive surgery using autogenous bone marrow graft and canine amniotic membrane). The initial non-surgical treatment resulted in a periodontal recovery rate of 37.6% and was found effective for treatment of early periodontal disease based on resolution of gingivitis and reduction of periodontal probing depths. Surgical treatment by closed gingival curettage to eliminate the diseased pocket lining resulted in a recovery rate of 48.8% and proved effective in substantially reducing deep periodontal pockets. Open root planing following flap elevation resulted in a recovery rate of 85.4% and was effective for deep and refractory periodontal pockets. Autogenous bone graft implantation combined with canine amniotic membrane as a biodegradable membrane was used in 18 premolar teeth and failed to improve advanced furcation defects in most teeth.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Repair of Experimental Plaque-Induced Periodontal Disease in Dogs

et al. 2007

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“…In the connective tissue, the dense cellular infiltrate consists mainly of plasma cells and lymphocytes. The osteoclastic resorption of alveolar bone may result in deep, narrow lesions extending vertically around a single root leaving the interdental space intact [38, 39]. The bone defect can involve the furcation areas of premolar and molar teeth.…”

Section: The Different Animal Models In Periodontologymentioning

confidence: 99%

Experimental Animal Models in Periodontology: A Review

Struillou¹,

Boutigny²,

Soueidan³

et al. 2010

TODENTJ

196

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In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models should make possible the validation of hypotheses and prove the safety and efficacy of new regenerating approaches using biomaterials, growth factors or stem cells. A review of the literature was carried out by using electronic databases (PubMed, ISI Web of Science). Numerous animal models in different species such as rats, hamsters, rabbits, ferrets, canines and primates have been used for modeling human periodontal diseases and treatments. However, both the anatomy and physiopathology of animals are different from those of humans, making difficult the evaluation of new therapies. Experimental models have been developed in order to reproduce major periodontal diseases (gingivitis, periodontitis), their pathogenesis and to investigate new surgical techniques. The aim of this review is to define the most pertinent animal models for periodontal research depending on the hypothesis and expected results.

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“…This model has been used to study the prevalence, severity and aetiological factors of PD (e.g. Gad, 1968;Sorensen et al, 1980); the clinical, histological and histopathological features associated with the disease (Lindhe et al, 1975;Hamp and Lindberg, 1977;Berglundh et al, 1991); analyze the efficiency of new therapeutic protocols (Jansen and Pilot, 1981;Haney et al, 1995); evaluate the regenerative potential of periodontal tissues (e.g. Iwata et al, 2009;Kwon et al, 2010) and utilized in comparative studies on the inflammatory response associated with the pathogenesis of the disease in dog an human (Skaleric et al, 1997;Papadimitriou et al, 2006).…”

Section: Introductionmentioning

confidence: 99%