Histopathology of the larger colonic polyp

Lescher, Theodore C.; Dockerty, Malcolm B.; Jackman, Raymond J.; Beahrs, Oliver H.

doi:10.1007/bf02617358

Cited by 36 publications

(3 citation statements)

References 2 publications

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“…cancer sequence [ 1,[3][4][5]11,12,14]. However, microscopic adenomatous alterations in single mucosal glands have been described [ 151, leading to the possibility that these may be precursors to carcinoma without always having to postulate a sequence from adenomatous polyp to cancer.…”

Section: Polypsmentioning

confidence: 99%

Small primary de novo adenocarcinoma of the colon with mesenteric lymphatic metastasis

Jelinek

Nava

Nime

1983

Journal of Surgical Oncology

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It is felt that the majority of colorectal carcinomas develop by malignant degeneration of previously benign adenomatous polyps. A small primary colon carcinoma, thought to have developed de novo directly from the colonic mucosa without the usual polyp-cancer sequence, is reported. This small nonulcerated lesion did not have the gross endoscopic appearance of a carcinoma and was associated with lymphatic metastasis. The need to include fiber-optic colonoscopy as part of the routine preoperative work-up and postoperative follow-up to rule out synchronous and metachronous lesions not detected by barium contrast x-ray studies is stressed.

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Section: Polypsmentioning

confidence: 99%

Small primary de novo adenocarcinoma of the colon with mesenteric lymphatic metastasis

Jelinek

Nava

Nime

1983

Journal of Surgical Oncology

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“…Moreover, these percentages decrease dramatically to 3.2 % in patients observed from the fourth to the ninth year after ablation of the polyps. Hellwig (1960), Enterline, Evans, Mercudo, Miller, and Fitts (1962), Knight, (1963), Grinnel (1964), andLesher, Dockerty, Jackman, andBeahrs (1967) give similar results. Awareness of the relationship between polyps and cancer has given rise to the belief that intestinal cancer arises from pre-existing polyps.…”

Section: Relationship Of Polyps To Cancermentioning

confidence: 84%

Polyps of the rectum and colon

Potet¹,

Soullard²

1971

Gut

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“…Obviously, this is not logical. Furthermore, failure to identify a residual adenomatous component does not indicate that the carcinoma arises de novo, as the carcinoma may have replaced a preexisting precursor adenoma [30,31].…”

Section: Discussionmentioning

confidence: 99%

Early Colorectal Cancer with Special Reference to the Superficial Nonpolypoid Type from a Histopathologic Point of View

et al. 2000

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The incidence and histopathologic characteristics of nonpolypoid (superficial type) early colorectal carcinomas were studied and compared with those of the polypoid type. The superficial type was subclassified as elevated (type IIa), type IIa with central depression (type IIa + IIc), plain (type IIb), depressed (type IIc), and IIc with marginal elevation (type IIc + IIa). The superficial type comprised 22% and 27% of intramucosal and submucosal carcinomas, respectively. Pure type IIb was not found, and there were only three pure type IIc lesions. Type IIa + IIc and IIc + IIa (and IIc) showed a significantly higher rate of submucosal invasion among the small tumors (59% and 71% less than 20 mm, respectively) compared to the polypoid type; type IIa showed no significant difference. The incidence of lymph node metastasis among submucosal carcinomas showed no significant difference between the superficial type and the polypoid type. About 64% and 52% of type IIa and IIa + IIc tumors accompanied residual adenoma, suggesting that they originated from small, flat adenomas through the adenoma-carcinoma sequence, whereas type IIc + IIa (and IIc) did not have an adenomatous component, implying that they arose de novo or originated through an adenoma-carcinoma sequence at a smaller size than the type IIa and IIa + IIc lesions. Superficial-type early colorectal carcinomas are not rare, and they are not uniform in nature. Rapid growth and invasion to the submucosa is characteristic of superficial-type lesions with a central depression, and only superficial depressed (type IIc + IIa, IIc) lesions can arise de novo. Although they grow rapidly to invade the submucosa, it cannot be said that they show more aggressive behavior than the polypoid type.

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Histopathology of the larger colonic polyp

Cited by 36 publications

References 2 publications

Small primary de novo adenocarcinoma of the colon with mesenteric lymphatic metastasis

Small primary de novo adenocarcinoma of the colon with mesenteric lymphatic metastasis

Polyps of the rectum and colon

Early Colorectal Cancer with Special Reference to the Superficial Nonpolypoid Type from a Histopathologic Point of View

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