Histopathology of the Salivary Glands

Skálová, Alena; Hellquist, Henrik

doi:10.1007/978-3-540-46915-5

Cited by 48 publications

(68 citation statements)

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“…Translocation of crTc1 and maml2 genes is typical for mucoepidermoid carcinoma 11 . it has also prognostic importance, since it has been associated with longer survival time, fewer local recurrences, and a decreased tendency to metastasize 12 . detection of the fusion genes eTV6 and NTrK3 (ref.…”

Section: Genetic Abnormalities In Salivary Tumoursmentioning

confidence: 99%

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance

Brož¹,

Šteiner²,

Salzman³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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, Ivo Starek aAims. To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters Methods. MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffinembedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis. Results. Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients. Conclusion. A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.

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Section: Genetic Abnormalities In Salivary Tumoursmentioning

confidence: 99%

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance

Brož¹,

Šteiner²,

Salzman³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…It does not form a distinct mass clinically and does not have a capsule. [7,8] These two features differentiate IL from sialolipoma, [7,8,12,16,17,19] and hence our case was diagnosed as IL. This condition is uncommon and chiefly affects the major SG (primarily the parotid).…”

Section: Discussionmentioning

confidence: 99%

“…Causes of IL include diabetes mellitus, cirrhosis, chronic alcoholism, malnutrition, and hormonal disturbances. [1,7,8] Our patient had hypothyroidism since 4 years. It is difficult to establish whether hypothyroidism resulted in this fatty infiltration of MSG, due to lack of literature.…”

Section: Discussionmentioning

confidence: 99%

“…[7] Among these, interstitial lipomatosis (IL) is an overgrowth of adipose tissue throughout the SG and often associated with systemic factors and conditions, that should be histologically differentiated from sialolipoma, a neoplasm. [1,7,8] A rare case of IL of the upper lip in a hypothyroid patient is presented here, that required pathological insight and clinical correlation for diagnosis. An internet search in English literature did not reveal any cases reported of IL of the upper lip, thereby adding to the rarity of the case.…”

Section: Introductionmentioning

confidence: 99%

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Interstitial lipomatosis of minor salivary gland: Fight for a place with sialolipoma

Suma¹,

Kumar²,

Samanta³

et al. 2017

JCRI

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The aim of this article is to report an uncommon lipomatous minor salivary gland (MSG) lesion of the upper lip that was diagnosed with pathological insight and clinical correlation. Differential diagnosis of fat containing salivary gland (SG) tumors will also be discussed. MSG lesions constitute a diverse group encompassing non-neoplastic lesions, benign neoplasms, and malignant neoplasms of varying grades. A rare subset among these includes the lipomatous SG lesions. Interstitial lipomatosis (IL) is an overgrowth of adipose tissue throughout the SG, that should be histologically differentiated from sialolipoma and infiltrating lipoma, which is neoplasms. The former is associated with systemic conditions while the latter is not. This case is of IL in a 55-year-old woman with hypothyroidism. A search in English literature did not reveal any cases of IL of the upper lip. The fact that SG neoplasms are more common in the upper lip than nonneoplastic lesions adds to the rarity of this case. Thus, this report adds another entity in the differential diagnosis of upper lip lesions and underlines the need to differentiate it from lipomatous neoplasms.

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“….Not only the salivary glands AdCC can also involve lacrimal and ceruminous glands as well as other sites in the head and neck 3, 4 .…”

mentioning

confidence: 99%

Adenoid Cystic Carcinoma of Tongue: A Case Report & Review of Literature

K¹,

Sudha²,

C.M³

et al. 2017

IOSR JDMS

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Histopathology of the Salivary Glands

Cited by 48 publications

References 0 publications

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance

Interstitial lipomatosis of minor salivary gland: Fight for a place with sialolipoma

Adenoid Cystic Carcinoma of Tongue: A Case Report & Review of Literature

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