Histopathology of the Skin in Dermatomyositis

Janis, John F.

doi:10.1001/archderm.1968.01610120030004

Cited by 118 publications

(23 citation statements)

References 13 publications

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“…The clinical and histological findings support the diagno sis of dermatomyositis and a cutaneous mucinosis. The histologic and histochemical findings of the skin are consistent with the findings of others that the mucinous material was noted by J anis and W inkelman [5] in their pa tient with dermatomyositis.…”

Section: Commentsupporting

confidence: 90%

“…It is well established that mucin deposition can follow inflamma tory processes, but it is becoming increasingly evident that mucinosis de posits are associated with more serious and significant systemic abnormali ties. Mucin is a consistent finding in lupus erythematosus and in dermato myositis, as shown by Janis and W inkf.lman [5].…”

Section: Commentsupporting

confidence: 64%

“…Mucinous material was also not present in the muscle in the previous study [5], The significant pathologic changes of the muscle were inflamma tion, atrophy, proliferation of the sarcolemmic nuclei and a vacuolar degen eration of the muscle bundles.…”

Section: Commentmentioning

confidence: 54%

“…The association of dermatomyositis and lichen myxedeniatosus is thus not common, although a reverse inference has been made by J anis and W inkelman [5] in their series of patients with dermatomyositis. In that series they noted the presence of mucin (hyaluronic acid) in the cutaneous biopsies of patients in the series presented clinically with a cutaneous mu cinosis.…”

Section: Commentmentioning

confidence: 97%

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Dermatomyositis and Lichen Myxedematosus

Johnson¹,

Horowitz²,

Charles³

et al. 1973

Dermatology

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Section: Commentsupporting

confidence: 90%

Section: Commentsupporting

confidence: 64%

Section: Commentmentioning

confidence: 54%

Section: Commentmentioning

confidence: 97%

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Dermatomyositis and Lichen Myxedematosus

Johnson¹,

Horowitz²,

Charles³

et al. 1973

Dermatology

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“…11 Periorbital edema secondary to mucin deposition, a striking finding in several patients reported with SHJCM, may also be an important clinical clue to the diagnosis of juvenile dermatomyositis. 12 In addition, patients with dermatomyositis may develop atypical clinical lesions secondary to cutaneous mucin deposition.…”

Section: Discussionmentioning

confidence: 99%

Self-healing juvenile cutaneous mucinosis

Cowen

Scott

Mercurio

2004

Journal of the American Academy of Dermatology

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Keratinocyte apoptosis and p53 expression in cutaneous lupus and dermatomyositis

Pablos¹,

Santiago²,

Galindo³

et al. 1999

J. Pathol.

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Keratinocyte apoptosis may be induced by ultraviolet‐B radiation and represents a potential source of fragmented autoantigens in autoimmune diseases. This study investigates whether excessive keratinocyte apoptosis occurs in the skin lesions of cutaneous lupus (CLE) and dermatomyositis (DM) and the potential mechanisms responsible for this phenomenon. Skin biopsies have been studied from 19 patients with CLE and DM, eight with scleroderma, and five healthy controls. Apoptosis was detected by in situ end‐labelling of fragmented DNA. The expression of Bcl‐2, PCNA, p53, and Ki‐67 proteins was studied by immunohistochemistry. In DM and CLE skin, the number of apoptotic keratinocytes was significantly increased (p=0·008) compared with normal skin. In both diseases, a large accumulation of apoptotic keratinocytes and apoptotic bodies was present in the disrupted basal zone. Unlike normal skin, a large number of keratinocytes, particularly those morphologically apoptotic, expressed p53 protein. A significant increase in the number of proliferating Ki‐67 positive (p=0·0007) and PCNA‐positive (p=0·0008) nuclei was also observed. In both CLE and DM, exaggerated and inappropriate keratinocyte apoptosis occurs. It is associated with increased expression of p53 and PCNA. This suggests that normal solar radiation alone or in combination with additional local factors induces DNA damage and excessive keratinocyte apoptosis in these autoimmune diseases of the skin. Apoptosis can mediate the severe epidermal lesions observed in both diseases and the release of fragmented autoantigens into the dermis. Copyright © 1999 John Wiley & Sons, Ltd.

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Histopathology of the Skin in Dermatomyositis

Cited by 118 publications

References 13 publications

Dermatomyositis and Lichen Myxedematosus

Dermatomyositis and Lichen Myxedematosus

Self-healing juvenile cutaneous mucinosis

Keratinocyte apoptosis and p53 expression in cutaneous lupus and dermatomyositis

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