Histoplasma capsulatum tenosynovitis in a patient with rheumatoid arthritis-scleroderma overlap syndrome

Filali, Saoussan Mahfoud; Faïk, Afaf; Allali, F.; Jahid, Ahmed; Chihab, W.; Hassani, S. El; Hajjaj–Hassouni, N.

doi:10.1016/j.jbspin.2006.02.002

Cited by 12 publications

(3 citation statements)

References 8 publications

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“… E. Cucurull [ 13 ] 2005 42/F Systemic lupus erythematosus New Orleans, Lousiana Yes, corticosteroids, hydroxychloroquine, and azathioprine Pain and swelling in the left hand No works at an immunology laboratory No Valdecoxib, Triamcinolone injection, itraconazole 200 mg daily x 12 months Fungal Culture Survived, repeat MRI of the hand showed marked improvement of the edematous signal S.M. Filali[ 14 ] 2006 43/F Rheumatoid Arthritis, Scleroderma, non-Hodgkin’s malignant lymphoma of the parotid gland NA Yes, chemotherapy, radiation, prednisone, penicillamine Swelling in hands and knees No NA No Aspiration, Amphotericin B (no effect after 6 months), itraconazole (improved after 1 year) Periodic Acid Schiff Survived, the peroneus brevis and tibialis anterior tendons were normal and the peroneus longus tendon was improved. S.Y.…”

Section: Resultsmentioning

confidence: 99%

Upper extremity Histoplasma capsulatum treatment with isavuconazole

Le¹,

Perkins²,

Sierra-Hoffman³

et al. 2021

IDCases

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Extrapulmonary Histoplasma capsulatum infections in the immunocompetent population are rare and pose a diagnostic challenge. Upper extremity histoplasmosis without a primary lung infection is uncommon. It is possible to acquire it by inadvertent trauma with direct inoculation. Our case describes an immunocompetent patient with progressive swelling with minimal pain in the wrist associated with a small puncture wound on the left dorsal forearm. The initial workup failed to identify a specific etiology. For the following six weeks, the patient experienced progressive worsening of symptoms, warranting a referral to an orthopedic hand surgeon. Left lower extremity magnetic resonance imaging (MRI) findings were non-specific. The surgeon performed a surgical exploration and debridement with the excision of hypertrophic tissue. Initial stains showed a granulomatous tissue but did not reveal an organism; however, a month later, mold was identified on the growth medium. The patient was initiated in isavuconazole empiric therapy. Four weeks later, a matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) confirmed the diagnosis as Histoplasma capsulatum . The patient had clinical remission with isavuconazole used as the United States Food and Drug Administration (FDA) off label use.

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Section: Resultsmentioning

confidence: 99%

Upper extremity Histoplasma capsulatum treatment with isavuconazole

Le¹,

Perkins²,

Sierra-Hoffman³

et al. 2021

IDCases

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show abstract

“…hepatitis C virus, Cytomegalovirus, Varicella-zoster virus, Parvovirus B19, Human T-Cell Lymphoma/Lymphotrophic Virus Type-1) and bacterial pathogens (e.g. Borrelia Burgdorferi, Helicobacter pylori, Histoplasma capsulatum, Staphylococcus lugdunensis) on scleroderma patients [61,[76][77][78][79][80][81][82][83][84]. So, as showed by IFN production by plasmacytoid dendritic cell (pDC) our myeloid dendritic cell (mDC) after TLR activation model proposed by Borden and colleagues, the recognition of PAMPs of these microorganisms by TLRs could be the initial signal to trigger the development of autoimmune diseases (Fig.…”

Section: Interferons and Sclerodermamentioning

confidence: 99%

Interferons and scleroderma—A new clue to understanding the pathogenesis of scleroderma?

2008

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“…3 Compromise of the skeletal system and joints is typically difficult to recognize due its nonspecific symptoms. 5 The correct surgical management of histoplasmosis in these locations has not been well described. We present a case report and conduct a comprehensive systematic review of the literature to generate awareness of the disease among hand surgeons and to describe the surgical and medical treatment of histoplasmosis involving bone, joints, synovia, and tendons in the upper extremities and their respective outcomes.…”

Section: Introductionmentioning

confidence: 99%

Histoplasmosis of the Upper Extremities: Clinical Case, Treatment Algorithm, and Systematic Review

Huayllani

Restrepo

Boczar

et al. 2020

Hand (New York, N,Y.)

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Background: Histoplasmosis of the upper extremities is extremely rare, and there is no consensus in its management. The aim of this study was to present a case report and literature review of histoplasmosis in the upper extremities to provide the best treatment recommendation and to increase awareness of this disease. Methods: A systematic review of the literature was performed in PubMed, MEDLINE, and EMBASE databases with the search terms “(Tenosynovitis AND histoplasmosis)” OR “(Upper limbs AND histoplasmosis)” OR “(Upper extremities AND histoplasmosis)” OR “((finger OR arm OR hand OR forearm OR wrist) AND histoplasmosis).” Manuscripts were included in the study if they described diagnosis of histoplasmosis in the bone, joint, synovia, or tendons of the upper extremities. Results: In all, 14 manuscripts and 15 cases of histoplasmosis of the upper extremities from 1992 to 2015 met the inclusion criteria. Eight (53.3%) patients were diagnosed with tenosynovitis, 5 (33.3%) with osteomyelitis, 1 (6.7%) with carpal tunnel syndrome, and 1 (6.7%) with joint wrist abscess. Immunosuppression, travel history, previous diagnosis with histoplasmosis, and persistent symptoms may suggest infectious causes. Surgery and medical treatment together are recommended to optimize outcomes compared with single treatment alone. Conclusions: Histoplasmosis of the upper extremities may have various clinical presentations, including tenosynovitis, osteomyelitis, carpal tunnel syndrome, and joint wrist abscess. The type of surgical approach may depend on the etiology of disease. Increased awareness and knowledge of the clinical signs, symptoms, and effective treatment modalities will help decrease possible complications, such as tendon rupture and functional impairment of the upper extremities.

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Histoplasma capsulatum tenosynovitis in a patient with rheumatoid arthritis-scleroderma overlap syndrome

Cited by 12 publications

References 8 publications

Upper extremity Histoplasma capsulatum treatment with isavuconazole

Upper extremity Histoplasma capsulatum treatment with isavuconazole

Interferons and scleroderma—A new clue to understanding the pathogenesis of scleroderma?

Histoplasmosis of the Upper Extremities: Clinical Case, Treatment Algorithm, and Systematic Review

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