Histoplasmose pulmonaire chez un patient immunocompétent avec nodules pulmonaires multiples évoluant vers la nécrose

Chaptal, Milène; Gallois, J.-C.; Étienne, Noémie; Mathon, G; Nicolas, M.; Cadelis, G.

doi:10.1016/j.rmr.2020.04.004

Cited by 1 publication

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“…Although Martinique is an endemic area for histoplasmosis, most cases are related to massive exposure [ 4 , 10 ]. In 2020, a similar case was described by colleagues in Guadeloupe [ 17 ].…”

Section: Discussionsupporting

confidence: 52%

Acute pulmonary histoplasmosis of immunocompetent subjects from Martinique, Guadeloupe and French Guiana: a case series

et al. 2023

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Introduction Histoplasmosis is a fungal disease caused by Histoplasma capsulatum. Histoplasma capsulatum var capsulatum is found in Martinique. Cluster cases following working in deserted house, have been described in Martinique. Cases of acute pulmonary histoplasmosis have been described in immunosuppressed individuals, or in case of substantial exposure to reservoirs of Histoplasma capsulatum; however, cases of acute histoplasmosis are rare in immunocompetent individuals. Cases series We report a series of 4 cases of sporadic acute pulmonary histoplasmosis in immunocompetent subjects. Investigation revealed definite exposure in one patient and 3 cases with potential exposure. The diagnosis was microbiological and histological in 3 patients and histological in one patient. All subjects had positive serology to histoplasmosis. Pulmonary involvement was in the form of nodules and micronodules in 3 cases and ground glass lesions in one case. Patients were treated with itraconazole for 3 months and all had a favourable outcome. Conclusion We report a series of 4 cases of acute pulmonary histoplasmosis in immunocompetent individuals, occurring in a context where exposure was uncertain. This raises the problem of occult exposure in the Caribbean. Interventions to raise awareness and encourage caution are warranted targeting the population of the French West Indies and French Guiana.

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“…Although Martinique is an endemic area for histoplasmosis, most cases are related to massive exposure [ 4 , 10 ]. In 2020, a similar case was described by colleagues in Guadeloupe [ 17 ].…”

Section: Discussionsupporting

confidence: 52%