“…HLH has been previously reported among HIV patients with and without disseminated infections. HLH is notably a known complication of acute disseminated histoplasmosis in both HIV+ and HIV- patients (Subedee and Van Sickels, 2015 ; Townsend et al, 2015 ; Jabr et al, 2019 ). Besides histoplamosis, the main etiology for HLH in AIDS patients are Kaposi sarcoma or lymphoma (B cell, T cell, or primary effusion lymphoma), but also toxoplasmosis, CMV disease, mycobacterial infections, and other opportunistic infections, such as candidiasis and pneumocystosis (Bhatia et al, 2003 ).…”