Histoplasmosis: Epidemiology in Latin America

Gómez, Beatriz L.

doi:10.1007/s12281-011-0073-7

Cited by 23 publications

(26 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PDH symptoms are nonspecific and may be similar to those of other infectious diseases, thus complicating diagnosis and treatment (1,3). In Colombia and other countries in the Americas where the disease is endemic and where access to highly active antiretroviral therapy (HAART) is limited, histoplasmosis is a major cause of mortality (up to 30%) in PLWHA (4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Validation of an Enzyme-Linked Immunosorbent Assay That Detects Histoplasma capsulatum Antigenuria in Colombian Patients with AIDS for Diagnosis and Follow-Up during Therapy

Cáceres

Scheel

Tobón

et al. 2014

Clin. Vaccine Immunol.

Self Cite

View full text Add to dashboard Cite

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy. Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum and is most frequently diagnosed in the American continent. In persons living with HIV/AIDS (PLWHA), an infection often develops into a clinical form called progressive disseminated histoplasmosis (PDH), which has a high mortality if not treated early (1, 2). PDH symptoms are nonspecific and may be similar to those of other infectious diseases, thus complicating diagnosis and treatment (1, 3). In Colombia and other countries in the Americas where the disease is endemic and where access to highly active antiretroviral therapy (HAART) is limited, histoplasmosis is a major cause of mortality (up to 30%) in PLWHA (4-9).Detection of circulating Histoplasma antigens in urine specimens by an antigen capture enzyme-linked immunoabsorbent assay (ELISA) is highly sensitive (95%), but this test is not generally available outside the United States (10, 11). To make such a test available to resource-challenged countries, a similar Histoplasma antigen capture ELISA was developed at the Centers for Disease Control and Prevention (CDC) (12) and was validated in a cohort of AIDS patients in Guatemala, demonstrating a sensitivity of 81% infections, 23 were identified as M. tuberculosis and 1 was identified as M. avium-Mycobacterium intracellulare; 4 could not be identified to the species level.

show abstract

mentioning

confidence: 99%

Validation of an Enzyme-Linked Immunosorbent Assay That Detects Histoplasma capsulatum Antigenuria in Colombian Patients with AIDS for Diagnosis and Follow-Up during Therapy

Cáceres

Scheel

Tobón

et al. 2014

Clin. Vaccine Immunol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Histoplasmosis is a systemic fungal disease which has a worldwide distribution. It is one of the most common respiratory mycosis in endemic regions of the United States and Latin America . In Brazil, histoplasmosis has been described in several regions especially in the Midwest, Northeastern and Southeast regions of the country …”

Section: Introductionmentioning

confidence: 99%

Role of western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil

Almeida

Damasceno

Pizzini

et al. 2019

Mycoses

View full text Add to dashboard Cite

Summary Background Histoplasmosis is a frequent fungal infection in HIV/AIDS patients, with high morbimortality rates when diagnosis and treatment are delayed. Antibody detection, which is faster than the gold standard culture test, hastens the laboratory investigation. Objectives To evaluate the role of WB for antibody detection in the diagnosis of histoplasmosis among HIV/AIDS patients. Patients and Methods Fifty patients with proven or probable histoplasmosis were included. Clinical, epidemiological and laboratory data were described in the same population after a review of their medical records. WB was performed using deglycosylated histoplasmin. Results About 82% of patients were adult males and the mean age was 39.3 years. CD4+ T lymphocyte count less than 150 cells/mm3 was observed in 62% patients. Antibodies against Histoplasma capsulatum M antigen were detected in 62% of patients, and against both M and H antigens in 28% of individuals. Sera from 10% of patients were nonreactive. Histoplasmosis was the first opportunistic infection in 38% of the cases. Disseminated and pulmonary histoplasmosis occurred in 84% and 16% of patients, respectively. The overall mortality was 16%. Conclusion WB could be useful for the histoplasmosis diagnosis in HIV/AIDS patients because of its easefulness and good sensitivity in a population where antibody production is hampered.

show abstract

“…Furthermore, after exposure to the fungus, people may experience a latent infection that can be reactivated. People at risk of reactivation of latent histoplasmosis include transplant recipients, patients with hematologic malignancies, those undergoing corticosteroid therapy, or patients in the advanced stages of infection with human immunodeficiency virus-acquired immunodeficiency disease syndrome (HIV-AIDS) [1,8,9]. Histoplasmosis is often diagnosed in urban and rural areas and may affect farmers, gardeners, housekeepers, builders, explorers, speleologists, and archaeologists.…”

Section: Introductionmentioning

confidence: 99%

Capacity ofHistoplasma capsulatumto Survive the Composting Process

Londoño

León

McEwen

et al. 2019

Applied and Environmental Soil Science

View full text Add to dashboard Cite

Histoplasma capsulatum (H. capsulatum) is a thermal-dimorphic fungus, the causal agent of histoplasmosis. Its presence in the environment is related with chicken manure due to their high nitrogen and phosphorus content. In Colombia, chicken manure is the most used raw material in the composting process; however, there is no information about the capacity of H. capsulatum to survive and remain viable in a composted organic fertilizer. To address this question, this study shows three assays based on microbiological culture and the Hc100 nested PCR. First, a composting reactor system was designed to transform organic material under laboratory conditions, and the raw material was inoculated with the fungus. From these reactors, the fungus was not isolated, but its DNA was detected. In the second assay, samples from factories where the DNA of the fungus was previously detected by PCR were analyzed. In the raw material samples, 3 colonies of H. capsulatum were isolated and its DNA was detected. However, after the composting process, neither the fungus was recovered by culture nor DNA was detected. In the third assay, sterilized and nonsterilized organic composted samples were inoculated with H. capsulatum and then evaluated monthly during a year. In both types of samples, the fungus DNA was detected by Hc100 nested PCR during the whole year, but the fungus only grew from sterile samples during the first two months evaluated. In general, the results of the assays showed that H. capsulatum is not able to survive a well-done composting process.

show abstract

Histoplasmosis: Epidemiology in Latin America

Cited by 23 publications

References 46 publications

Validation of an Enzyme-Linked Immunosorbent Assay That Detects Histoplasma capsulatum Antigenuria in Colombian Patients with AIDS for Diagnosis and Follow-Up during Therapy

Validation of an Enzyme-Linked Immunosorbent Assay That Detects Histoplasma capsulatum Antigenuria in Colombian Patients with AIDS for Diagnosis and Follow-Up during Therapy

Role of western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil

Capacity ofHistoplasma capsulatumto Survive the Composting Process

Contact Info

Product

Resources

About