Histoplasmosis of Lungs

Sulfonamides in Experimental Nocardiosis, Histoplasmosis, and South American Blastomycosis

“…Usefulness in disseminated infections in children was later stressed by C hristie [1958] but in view of rather discouraging results in pulmo nary and disseminated forms [e. g., Schwartz, 1954] and while the much more effective drug, amphotericin B, became available, the potential value of sulfonamides in histoplasmosis was almost forgotten, especially in the United States. Reappraisal was suggested, e. g., by Y ates et al [1960], who recommended combining the sulfonamides with amphotericin B. Sulfadiazine was the compound most often used in the earlier trials.…”

The Clinical Diagnosis of Histoplasmosis

“…in one hour. The patient had not 14). Pneumonic infiltrate in right lower lung field with hilar enlargement.…”

“…The earlier attempts were made by Kunstadter, Whitcomb and Milzer,11 Christie/ 2 and Beadenkopf and Loosli. 13 More recently, Schwartz 14 made a clinical differentiation of pulmonary histoplasmosis but After 10 years of experience with histoplasmosis, I am convinced that certain clear-cut clinical pictures are emerging and that it is of great importance to clarify these in terms of frequency, diagnosis and prognosis. The clinical spectrum of the disease as it is presently emerging can perhaps best be illustrated by table l. The different clinical types of the disease will be described in detail.…”

“…FIGt:RE 18 (case14). Development of calcification at site of earlier infiltrate seven years after date offigure 17.…”

Correlation between pathogenicity and temperature sensitivity in different strains of Histoplasma capsulatum.

“…The morphogenic process and the factors that affect it are ofconsiderable interest, because growth ofthe yeast phase appears to be required for pathogenicity (2).…”