Histoplasmosis of the central nervous system.

Tan, Veronique Kiak Mien; Wilkins, P.; Badve, Sunil; Coppen, M J; Lucas, Sebastian; Hay, R. J.; Schön, F

doi:10.1136/jnnp.55.7.619

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…Two potential mechanisms for intracranial spread of frontal sinus infection have been described in the literature: through communicating diploic venous channels or alternatively through direct invasion of the posterior frontal sinus wall [I, 4,5]. In this patient, the defect demonstrated in the left…”

Section: Discussionmentioning

confidence: 88%

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Successful Medical Treatment of a Spinal Histoplasmoma

Kelly

Smith²,

McQuillen³

1994

Journal of Neuroimaging

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A woman with previously treated disseminated histoplasmosis was admitted with progressive paraparesis. Magnetic resonance imaging showed multifocal cerebritis and spinal histoplasmoma. She recovered following a second treatment with amphotericin B. This is the fourth reported patient with intramedullary spinal histoplasmoma, and the first demonstrating successful treatment of the lesion with medical therapy alone.

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Section: Discussionmentioning

confidence: 88%

“…The use of steroids in the present patient may have hastened the progression of the illness. In one of the previously reported patients with spinal histoplasmoma, the chronic administration of prednisone to treat an unrelated medical condition was thought to have been the cause for the patient's relapse [ 4].…”

Section: Discussionmentioning

confidence: 99%

Successful Medical Treatment of a Spinal Histoplasmoma

Kelly

Smith²,

McQuillen³

1994

Journal of Neuroimaging

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“…A case of disseminated histoplasmosis in a 72-year-old man was reported, it was the first report of histoplasmosis presenting as a myelopathy. 14 Spinal cord compression caused by histoplasmosis is high in the patient with history of organ transplantation, 8 animal breeders, 10 farm workers, 12,13 endemic areas, 7,9 and human immunodeficiency virus infection. 7,12,13 It was intra-spinal cord abscess.…”

Section: Discussionmentioning

confidence: 99%

Intramedullary Spinal Cord Compression Caused by Histoplasma capsulatum: A Case Report and Meta-Analysis

N’dri-Oka

Adou

Tokpa

et al. 2015

IJNS

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Nine cases of intramedullar histoplasmosis have been published in the literature. In six cases, spinal cord compression was associated with brain localization or with contex of disseminated histoplasmosis. The authors are reporting here the third isolated spinal cord compression in immunocompetent 42-year-old African-rabbits breeder, a woman. This case was successfully managed with surgical removal of the lesion associated to itraconazole during 8 months. Intramedullar lesion because of the Histoplasma capsulatum was necrosis granulomatous localized at spinal conus. In conclusion, according to literature data the most frequent spinal cord compression caused by histoplasmosis capsulatum. General risk factors include residence in endemic areas as well as immunosuppression. Endemic areas include Africa, Australia, parts of Eastern Asia, and America (Mississippi, Missouri, and Ohio River valleys). Initial localization was cutaneous. Two histopathological forms reported are abscess and necrotizing granuloma. Management is mainly based on antifungus like itraconazole. Surgery is only necessary for the etiology diagnosis.

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“…However, in areas where Histoplasma is endemic, these lesions are generally well recognised and are unlikely to be confused with malignancy, particularly when tell-tale calcifications are present [3]. Mass lesions caused by Histoplasma infection may also occur in the central nervous system, including the spinal cord, and here can radiologically simulate a neoplasm [4][5][6][7]. Diffuse enlargement of the adrenal glands without a definable mass is not uncommon in Histoplasma infection [8].…”

Section: Discussionmentioning

confidence: 99%

Histoplasma-associated inflammatory pseudotumour of the kidney mimicking renal carcinoma

et al. 2009

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A 56-year-old female, originally from Suriname, with an otherwise unremarkable previous medical history was found to have a renal mass highly suspicious for renal cancer for which a nephrectomy was performed. Within the kidney, a tumourous mass was found which, on histological examination, showed an inflammatory pseudotumour caused by Histoplasma capsulatum. Further investigations revealed an idiopathic CD4 + lymphopenia. Mass lesions mimicking a malignant tumour caused by infection with Histoplasma have rarely been described. To the best of our knowledge, this is the first report of a Histoplasmaassociated inflammatory pseudotumour mimicking cancer occurring in the kidney

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Histoplasmosis of the central nervous system.

Cited by 21 publications

References 12 publications

Successful Medical Treatment of a Spinal Histoplasmoma

Successful Medical Treatment of a Spinal Histoplasmoma

Intramedullary Spinal Cord Compression Caused by Histoplasma capsulatum: A Case Report and Meta-Analysis

Histoplasma-associated inflammatory pseudotumour of the kidney mimicking renal carcinoma

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