Historical Background and Introductory Concepts

doi:10.1142/9789813222007_0001

Cited by 1 publication

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References 107 publications

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“…For n5, a = 13.3 ± 0.7 µT and b = 0.017 ± 0.002 mT −1 . This model is commonly used to describe superparamagnetic nanoparticles in the limit that the thermal energy exceeds the magnetic anisotropy energy [38]. The large magnetization and saturation behavior in these small nanoparticles is consistent with recent reports of superparamagnetism in hemozoin sam- ples [37,39].…”

Section: Resultssupporting

confidence: 87%

Diamond Magnetic Microscopy of Malarial Hemozoin Nanocrystals

et al. 2019

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Magnetic microscopy of malarial hemozoin nanocrystals is performed by optically detected magnetic resonance imaging of near-surface diamond nitrogen-vacancy centers. Hemozoin crystals are extracted from Plasmodium falciparum –infected human blood cells and studied alongside synthetic hemozoin crystals. The stray magnetic fields produced by individual crystals are imaged at room temperature as a function of the applied field up to 350 mT. More than 100 nanocrystals are analyzed, revealing the distribution of their magnetic properties. Most crystals (96%) exhibit a linear dependence of the stray-field magnitude on the applied field, confirming hemozoin’s paramagnetic nature. A volume magnetic susceptibility of 3.4 × 10 −4 is inferred with use of a magnetostatic model informed by correlated scanning-electron-microscopy measurements of crystal dimensions. A small fraction of nanoparticles (4/82 for Plasmodium falciparum –produced nanoparticles and 1/41 for synthetic nanoparticles) exhibit a saturation behavior consistent with superparamagnetism. Translation of this platform to the study of living Plasmodium -infected cells may shed new light on hemozoin formation dynamics and their interaction with antimalarial drugs.

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Section: Resultssupporting

confidence: 87%