Historical background of umbilical stem cell culture

Borys-Wójcik, Sylwia; Józkowiak, Małgorzata; Stefańska, Katarzyna; Knap, Sandra; Pieńkowski, Wojciech; Gutaj, Paweł; Bruska, M; Kempisty, Bartosz

doi:10.2478/acb-2019-0002

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…It was performed in France in a child with Fanconi Anaemia (FA) (Ballen et al 2013 ). In Poland, the first cord blood stem cell transplant took place in 1994 to treat a boy suffering from acute myelogenous leukaemia (Borys-Wójcik et al 2019 ). In 2007, there was the first Polish transplant of umbilical cord blood which was previously collected, processed and stored in a private bank (Borys-Wójcik et al 2019 ; PBKM 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…In Poland, the first cord blood stem cell transplant took place in 1994 to treat a boy suffering from acute myelogenous leukaemia (Borys-Wójcik et al 2019 ). In 2007, there was the first Polish transplant of umbilical cord blood which was previously collected, processed and stored in a private bank (Borys-Wójcik et al 2019 ; PBKM 2007 ). Since then, umbilical cord blood stem cells have been transplanted over 40.000 times worldwide including a few transplants in Poland (Ballen 2017 ; FamiCord Group 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Women’s attitude towards umbilical cord blood banking in Poland

et al. 2021

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Umbilical cord blood (UCB) is considered as a valuable potential source of hematopoietic stem and progenitor cells. A process of collecting and storing UCB in the immediate period after the birth is called UCB banking. The study was conducted in order to determine women’s knowledge, awareness, preferences and attitude towards UCB banking in Poland, considering the sociodemographic and obstetric factors. A cross-sectional, self-administered, online questionnaire-based study including mostly multiple choice questions concerning attitude and awareness regarding UCB banking was conducted entirely online among Facebook female users in Poland. A total of 1077 participants correctly completed the survey. Most participants (n = 911, 84.6%) were aware of the possibility of UCB banking. Social media were considered as the main source of information (47.5%). However, the participants mostly indicated the doctor as their preferred source of reliable information (86.8%). The majority of women (61.8%) assessed their level of knowledge of UCB banking as still insufficient. Among the participants who supported UCB banking (70%), the following reasons were considered as the most vital: potential possibility of helping their child (93.9%) and helping other relatives (64.4%). More than half of the respondents (66.9%), who have not stored and are not willing to store their children’s UCB, indicated the high cost of UCB banking as the main reason of this decision. The knowledge and awareness of UCB storage and banking possibilities amongst women in Poland could be improved. The professional medical personnel should be a source of reliable information.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Women’s attitude towards umbilical cord blood banking in Poland

et al. 2021

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“…The first recipient of umbilical cord blood stem cells was a 5-year old boy with severe Fanconi anemia in 1988 [ 16 ]. In Poland, a successful frozen and banked umbilical stem cell transplantation in a boy with acute myeloblastic leukemia was performed eight years later [ 17 ]. Initially, UBC transplantation was limited to children, and both related and unrelated cord blood transplants have been performed with high rates of success for a variety of hematologic disorders and metabolic storage diseases [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Knowledge about Umbilical Cord Blood Banking and Genetic Tests among Pregnant Women from Polish Urban and Rural Areas between 2010–2012 and 2017

Szubert

Ilowiecka

Wilczyński

et al. 2020

IJERPH

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The aim of this study was to evaluate knowledge of umbilical cord blood (UBC) banking and prenatal genetic diagnosis among pregnant women from rural and urban areas, and how this knowledge changed within a five-year period. A survey by questionnaire was conducted between 2010 and 2012, and in 2017 in public hospitals; the study population comprised 6128 women, with 2797 patients from the years 2010–2012 and 3331 from the year 2017. 41% of the studied population declared that they were living in rural areas. In the 2010–2012 period, fewer women from rural areas knew about UBC banking. In 2017 that same relative difference in knowledge persisted, but the percentage of women who now knew about this procedure rose significantly in both studied groups. Prenatal diagnosis was more familiar for urban inhabitants both in 2010 and 2017 but as with the UBC data, a trend of growing awareness was also seen in pregnant women from rural areas. Knowledge of new techniques such as UBC banking and genetic tests has grown among pregnant women during the time frame of our study, but there is still a need to emphasize the benefits of these two possibilities to pregnant women, especially among rural inhabitants.

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“…Then, the collected samples are directly placed in culture flasks (explant cultures) or enzymatically digested (collagenase I/II, hyaluronidase, trypsin). In the next step, the processed solution is filtered or centrifuged and transferred into culture dishes and cultured in various media at 37 °C in a 5% CO 2 atmosphere [ 197 , 223 , 224 , 225 ]. Fortunately, the isolation of MSCs from the umbilical cord tissue is much more efficient.…”

Section: Mesenchymal Stem/stromal Cells Derived From Human and Animal Perinatal Tissuesmentioning

confidence: 99%

Mesenchymal Stem/Stromal Cells Derived from Human and Animal Perinatal Tissues—Origins, Characteristics, Signaling Pathways, and Clinical Trials

Kulus

Sibiak

Stefańska

et al. 2021

Cells

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Mesenchymal stem/stromal cells (MSCs) are currently one of the most extensively researched fields due to their promising opportunity for use in regenerative medicine. There are many sources of MSCs, of which cells of perinatal origin appear to be an invaluable pool. Compared to embryonic stem cells, they are devoid of ethical conflicts because they are derived from tissues surrounding the fetus and can be safely recovered from medical waste after delivery. Additionally, perinatal MSCs exhibit better self-renewal and differentiation properties than those derived from adult tissues. It is important to consider the anatomy of perinatal tissues and the general description of MSCs, including their isolation, differentiation, and characterization of different types of perinatal MSCs from both animals and humans (placenta, umbilical cord, amniotic fluid). Ultimately, signaling pathways are essential to consider regarding the clinical applications of MSCs. It is important to consider the origin of these cells, referring to the anatomical structure of the organs of origin, when describing the general and specific characteristics of the different types of MSCs as well as the pathways involved in differentiation.

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Historical background of umbilical stem cell culture

Cited by 5 publications

References 21 publications

Women’s attitude towards umbilical cord blood banking in Poland

Women’s attitude towards umbilical cord blood banking in Poland

Changes in Knowledge about Umbilical Cord Blood Banking and Genetic Tests among Pregnant Women from Polish Urban and Rural Areas between 2010–2012 and 2017

Mesenchymal Stem/Stromal Cells Derived from Human and Animal Perinatal Tissues—Origins, Characteristics, Signaling Pathways, and Clinical Trials

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