Historical evolution of automated blood culture systems

Ryan, Mitchell R.; Murray, Patrick R.

doi:10.1016/0196-4399(93)90051-n

Cited by 11 publications

(2 citation statements)

References 10 publications

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“…Blood cultures are routinely used whenever the presence of clinically significant bacteremia is suspected [1]. Several automated blood‐culture systems have been developed over the past three decades [2,3]. The introduction of automated blood‐culture systems has enabled an optimal microbiological yield, associated with a decrease in detection time and a reduction of the laboratory workload.…”

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False-positive blood cultures in a patient with acute myeloid leukemia

Meessen¹,

Pampus

Jacobs³

1999

Clinical Microbiology and Infection

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Tel: +31 43 3876643 Fax: +31 43 3876644 References 1. Aronson MD, Bor DH. Blood cultures. AM Intern Med 1987; 106: 246-53. 2. Ryan MR, Murray PR. Historical evolution of automated blood culture systems. Clin Mimbiol N e d e t t 1993; 1 5 105-8. 3. W b t e i n W. Current blood culture methods and systems: clinical concepts, technology, and interpretation of mule. Clin Infect Dis 1996; 23: 40-6. 4. Ziegler R, Johnsher I, Marms P, Lcnhardt D, Just H-M. Controlled clinical laboratory comparison of two supplemented aerobic and anaerobic media used in automated blood culture systems M detect bloodstream infections. J Clin Microbioll998; 3 6 65761. 5. Jorgcascn JH, Mirrct S, McDonald LC, et 11. Controlled clinical laboratory comparison of BACTEC plus aerobic/& medium with Bact/Alert aerobic F A N medium €or detection of bacteremia and f..9Mli.. J Clin Microbioll997; 35: 53-8. McRsen NEL, Jacobs JA. Blood volume in BACTEC plus/F culture bodes sampled using the direct-draw technique. Clin Microbiol Infect 1998 4 471-2. Alfa M, Sanche S, Roman S, Fiola Y, Lenton P, Harding G. Continuous quality improvements for introduction of automated blood cultun instrument. J Clin Microbiol 1995; 33: 1185-91. Martinez RM, Martinez R, P d Y, C w s J, Llosa J. A l m a g~~ M. An in&quent cause of false-positive blood cultures. Clin Microbiol Newslett 1993; 15: 7-8. Rhnbdonryolysis in acute Q fever Clin Minobiof Infect 1999; 5: 770-771Acute Q fever is a non-specific febrile illness caused by Cwciella burnetii. The most common clinical presentations of acute C. burnetii infection are atypical pneumonia and hepatitis [l]. Other complications of acute Q fever include hemolytic anemia, myocarditis, pericarditis, pancreatitis, thyroiditis, mesenteric panniculitis, mediastinal lymphadenopathy, orchitis, erythema nodosum and optic neuritis [2]. However, rhabdomyolysis is an apparently uncommon complication of C. burnetii infection, and this association has rarely been reported [MI. Here we report another case of severe

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False-positive blood cultures in a patient with acute myeloid leukemia

Meessen¹,

Pampus

Jacobs³

1999

Clinical Microbiology and Infection

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“…Blood cultures are one of the most significant single tests performed in the microbiology laboratory (2,21) and can account for up to 10% of the total microbiology supplies budget. Recently, many ''new-technology'' automated blood culture systems have been introduced (14,17,19,24,26). Despite the critical nature of this test, there is generally heavy reliance on the manufacturer's test site evaluation and little reliance on local in-hospital assessment.…”

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Continuous quality improvement for introduction of automated blood culture instrument

et al. 1995

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Despite the critical nature and high cost of blood cultures, hospitals rely on manufacturers' test site data. As a result, in-hospital testing and compliance evaluation of newly acquired instruments are seldom done. The goal of this study was to apply a continuous quality improvement approach and to develop assessment criteria for all stages from the purchase order, through the on-site instrument evaluation, to the compliance evaluation. Despite the introduction of an automated high-blood-volume instrument (BacT/Alert) in our hospital, 56% of adult patients had only one venipuncture and 89.5% had Յ20 ml of total blood volume sampled. False positives were associated with overfilling of bottles. These problems occurred because the phlebotomists did not like to perform multiple venipunctures on ill patients; therefore, they were drawing 20 ml of blood from one venipuncture and splitting it between two bottles. Unknown to the staff, the vacuum in the bottles draws significantly more than 10 ml of blood; therefore, the first bottle in the set was frequently overfilled and the second bottle was frequently underfilled. A diagrammatic guideline for a new blood culture protocol based on two venipunctures, taken one immediately after the other, to inoculate three bottles was developed. Compliance evaluation demonstrated that within 1 month of starting the new protocol, 74% of patients had at least two or more venipunctures and 60% had Ն30 ml of blood drawn per patient episode. This study demonstrates the need for continuous quality improvement, including compliance evaluation, to ensure that the potential benefits of newer blood culture technology are actually realized.

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