Historical Findings in Subjects from a High Socioeconomic Group Who Have Genital Infections with Herpes Simplex Virus

Knox,; Corey, Lawrence; Ha, Blough; Am, Lerner

doi:10.1097/00007435-198201000-00003

Cited by 30 publications

(9 citation statements)

References 0 publications

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“…8 Surveys of 3142 patients with genital herpes simplex infections report that the mean age of the first episode is 27 years for women and 31 years for men but 4% were older than 50 years when they developed the initial episode. 9 This is consistent with our finding that most patients with recurrent HSV-2 meningitis are young adults; yet, 5% of the reported patients are older than 60 years.…”

Section: Commentsupporting

confidence: 92%

Recurrent Herpes Simplex Virus Type 2 Meningitis in Elderly Persons

Davis

Guerre²,

Gerstein³

2010

Arch Neurol

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To review the ages of patients with recurrent herpes simplex virus type 2 (HSV-2) meningitis. Design: Case report and literature review back to 1970. Setting: Referral Veterans Affairs hospital. Results: Our patient developed his first episode of recurrent HSV-2 meningitis at 78 years of age, 57 years after his only episode of genital herpes simplex infection. Of 223 patients in the literature with recurrent HSV-2 meningitis, 5% occurred in patients older than 60 years and 19% in patients older than 50 years. Conclusions: Although recurrent meningitis due to HSV is primarily seen in young, sexually active adults, a surprising number of episodes of HSV meningitis can develop in older age. Meningitis due to HSV-2 should be in the differential diagnosis of aseptic meningitis in older patients.

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Section: Commentsupporting

confidence: 92%

Recurrent Herpes Simplex Virus Type 2 Meningitis in Elderly Persons

Davis

Guerre²,

Gerstein³

2010

Arch Neurol

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“…Most patients who seek medical attention for symptomatic genital HSV report from five to eight recurrences per year (16,24). Long-term natural history studies are not available to predict reliably whether and when recurrences decrease or change over time.…”

Section: Emergence Of Resistancementioning

confidence: 99%

Acyclovir prophylaxis for herpes simplex virus infection

Gold¹,

Corey²

1987

Antimicrob Agents Chemother

101

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ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transplant recipients and patients with hematologic malignancies undergoing induction chemotherapy should be screened routinely for HSV antibodies; seropositive individuals should receive prophylactic ACV during the period of most profound immunosuppression. Immunologically normal individuals with frequently recurring genital HSV or serious complications associated with outbreaks are candidates for long-term suppression with ACV.

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“…Although the data are limited, the ratio of nongonococcal urethritis to gonococcal urethritis is higher in white than in black men attending selected public health clinics in the US (23,24). Limited surveys also suggest that clinically apparent genital herpes is significantly more common in whites than in other racial categories (25 ). Genital herpes is often the first STD to be acquired in white men and women (25,26 ).…”

Section: Race and Sexmentioning

confidence: 99%

“…Limited surveys also suggest that clinically apparent genital herpes is significantly more common in whites than in other racial categories (25 ). Genital herpes is often the first STD to be acquired in white men and women (25,26 ). The reasons for these differences are speculative; they may reflect a higher threshold for seeking medical care among races other than white when infections are only mildly symptomatic, limited access to health care, or an unrecognized earlier infection in races other than white of lower socioeconomic status that provides a degree of immunity and decreases the rate of infection in the age group most commonly seeking treatment (27).…”

Section: Race and Sexmentioning

confidence: 99%

“…The reasons for these differences are speculative; they may reflect a higher threshold for seeking medical care among races other than white when infections are only mildly symptomatic, limited access to health care, or an unrecognized earlier infection in races other than white of lower socioeconomic status that provides a degree of immunity and decreases the rate of infection in the age group most commonly seeking treatment (27). With respect to genital herpes, races other than white are more likely to have been infected with orolabial HSV 1 in childhood, which may provide some protection against infection and disease manifestations caused by sexually transmitted HSV 2 (25,26 ).…”

Section: Race and Sexmentioning

confidence: 99%

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