Historical Foundations

Suckow, Mark A.; Baker, Henry J.

doi:10.1016/b978-0-12-814338-4.00001-5

Cited by 7 publications

(5 citation statements)

References 77 publications

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“…11 On the other hand, the post hoc analysis of the groups using 4% and 15% Moringa leaf extract gel showed no significant differences, presumably because of some confounding factors that could interfere with the wound healing process. 19 However, this study has some limitations. This study involved a limited number of samples and a limited variation of extract concentrations in the gel.…”

Section: Discussionmentioning

confidence: 89%

Effect of 4% and 15% moringa leaf extract gel on gingival wound healing in rats

Ramadhany,

Ambarawati,

Musyaffa

2023

Majalah Kedokteran Gigi Indonesia

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Traumatic dental procedures such as incisions and gingival flaps are the leading causes of injury to the gingival structure. One of natural ingredients that can potentially accelerate the wound healing process is Moringa leaves Moringa oleifera). Moringa leaf has several active compounds, one of which is flavonoids, which can be an antiinflammatory and antibacterial agent, and increase collagen synthesis. A randomized posttest-only control-group design was used in this study. 48 wistar rats were categorized into four groups: CMC-Na gel, hyaluronic acid, 4% Moringa leaf extract gel, and 15% Moringa leaf extract gel. The samples were then euthanized on days 1, 3, 5, and 7. The two-way ANOVA test described significant differences (p < 0.05) for all the components of the observation (neutrophils, fibroblasts, angiogenesis, and epithelial thickness). The lowest mean number of neutrophils, the highest mean number of fibroblasts, and the highest mean of angiogenesis were found in the 15% Moringa extract group on the 7th day. The highest mean epithelial thickness was found in the use of 4% Moringa extract on the 5thday. The microscopic images showed that the treatment group gained more effective wound healing processes than the control group. The microscopic image showed that, in terms of neutrophils, fibroblasts, and angiogenesis, 15% Moringa extract was more effective for wound healing compared to 4% Moringa extract.

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Section: Discussionmentioning

confidence: 89%

Effect of 4% and 15% moringa leaf extract gel on gingival wound healing in rats

Ramadhany,

Ambarawati,

Musyaffa

2023

Majalah Kedokteran Gigi Indonesia

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“…Their results showed high activity in the pregnant group only at the early stages of the experiment. This information could suggest that, in the context of rat pregnancy that lasts 21–23 days [ 48 ] tooth movement could be promoted during pregnancy because the action of resorption is faster than deposition.…”

Section: Discussionmentioning

confidence: 99%

Does the rate of orthodontic tooth movement change during pregnancy and lactation? A systematic review of the evidence from animal studies

Omar

Kaklamanos

2020

BMC Oral Health

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Background: The changes in bone homeostasis observed during pregnancy and lactation could result in alterations in the rate of orthodontic tooth movement, but research in human subjects presents significant ethical and practical limitations. Our aim was to compare the amount of orthodontic tooth movement between pregnant/ lactating or not animals. Methods: We searched without restrictions 8 databases and performed hand searching until July 2019 (PubMed, Central, Cochrane Database of Systematic Reviews, SCOPUS, Web of Science, Arab World Research Source, ClinicalTrials.gov, ProQuest Dissertations and Theses Global). We searched for studies comparing quantitatively the amount of orthodontic tooth movement between pregnant/lactating or not animals. Following retrieval and selection of studies, the collection of related data was performed and the risk of bias was assessed using the SYRC LE's Risk of Bias Tool. Exploratory synthesis was carried out using the random effects model. Results: Four studies were finally identified raising no specific concerns regarding bias. One study showed that lactation increased the rate of tooth movement by 50 % [p < 0.05]. Although an overall increase was noted in the pregnancy group as well, it did not reach statistical significance [3 studies, Weighted Mean Difference: 0.10; 95% Confidence Interval: − 0.04-0.24; p = 0.165]. Conclusions: The metabolic changes occurring during pregnancy and lactation may have an impact on the rate of tooth movement in animals. Although these animal experimental results should be approached cautiously, it could be safe practice to consider the impact of these physiological changes in the clinical setting.

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“…The causes of obesity in ZF rats also include hypertrophy and adipocyte hyperplasia, which are linked to their genetic predisposition. Other conditions observed in ZF rats include hyperinsulinemia and impaired glucose tolerance, which do not lead to overt diabetes [51,52].…”

Section: Animal Model Of Obesity Zucker Fatty Rats (Fa/fa)mentioning

confidence: 99%

Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models

Niewiadomska

Gajek-Marecka

Gajek

et al. 2022

Biology

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Metabolic syndrome (MetS) is a disease that has a complex etiology. It is defined as the co-occurrence of several pathophysiological disorders, including obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is currently a severe problem in the public health care system. As its prevalence increases every year, it is now considered a global problem among adults and young populations. The treatment of choice comprises lifestyle changes based mainly on diet and physical activity. Therefore, researchers have been attempting to discover new substances that could help reduce or even reverse the symptoms when added to food. These attempts have resulted in numerous studies. Many of them have investigated the bioactive potential of polyphenols as a “possible remedy”, stemming from their antioxidative and anti-inflammatory effects and properties normalizing carbohydrate and lipid metabolism. Polyphenols may be supportive in preventing or delaying the onset of MetS or its complications. Additionally, the consumption of food rich in polyphenols should be considered as a supplement for antidiabetic drugs. To ensure the relevance of the studies on polyphenols’ properties, mechanisms of action, and potential human health benefits, researchers have used laboratory animals displaying pathophysiological changes specific to MetS. Polyphenols or their plant extracts were chosen according to the most advantageous mitigation of pathological changes in animal models best reflecting the components of MetS. The present paper comprises an overview of animal models of MetS, and promising polyphenolic compounds whose bioactive potential, effect on metabolic pathways, and supplementation-related benefits were analyzed based on in vivo animal models.

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Historical Foundations

Cited by 7 publications

References 77 publications

Effect of 4% and 15% moringa leaf extract gel on gingival wound healing in rats

Effect of 4% and 15% moringa leaf extract gel on gingival wound healing in rats

Does the rate of orthodontic tooth movement change during pregnancy and lactation? A systematic review of the evidence from animal studies

Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models

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