Historical perspective: Two decades of progress in treating metastatic colorectal cancer

Lee, Rachel; Cardona, Kenneth; Russell, Maria C.

doi:10.1002/jso.25431

Cited by 50 publications

(52 citation statements)

References 173 publications

(342 reference statements)

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“…De los pacientes con CCR, el 25% tiene metástasis hepáticas (MH) al momento del diagnóstico, 50% las desarrollarán en el curso de su enfermedad y 33% sólo tendrá metástasis en el hígado. La sobrevida natural de los pacientes con MH es de 6 a 12 meses con una sobrevida a 5 años de 10%, lo cual aumenta a 24-32 meses cuando son sometidos a QMT 4,5 . Sin embargo, la resección de MH ofrece la mayor probabilidad de curación para pacientes en etapa IV, logrando actualmente sobrevidas a 5 años de 40%-45%, similares a los pacientes con CCR etapa III.…”

Section: Tratamiento Quirúrgico De Las Metástasis Hepáticas De Cáncerunclassified

“…Sin embargo, la resección de MH ofrece la mayor probabilidad de curación para pacientes en etapa IV, logrando actualmente sobrevidas a 5 años de 40%-45%, similares a los pacientes con CCR etapa III. Lamentablemente, sólo 20% de los pacientes con MHCCR se consideran resecables 4,8 .…”

Section: Tratamiento Quirúrgico De Las Metástasis Hepáticas De Cáncerunclassified

“…La evaluación oncológica debe estar basa-da en la biología del tumor (carga tumoral, enfermedad extrahepática, respuesta a terapia neoadyuvante, perfil de mutaciones). La evaluación técnica debe estar referida a obtener márgenes negativos preservando un remanente hepático futuro con adecuada irrigación y drenaje vascular y biliar 4,9 .…”

Section: Definición Actual De Resecabilidadunclassified

“…Los criterios actuales aceptados para resección hepática incluyen cualquier número de tumores, de cualquier localización en el hígado, con enfermedad extrahepática estable o resecable, remanente hepático futuro adecuado, compromiso venoso susceptible a resección o incluso reconstrucción, siempre manteniendo el objetivo fundamental de lograr márgenes microscópicos negativos 4 .…”

Section: Definición Actual De Resecabilidadunclassified

“…La NCCN no lo recomienda de uso rutinario, debido a que la QMT preoperatoria puede reducir su sensibilidad. -Volumetría 3D (TC): Es indispensable para evaluar el RHF, y disminuir la posibilidad de falla hepática preoperatoria, especialmente en hepatectomías mayores 4,9 .…”

Section: Estudio De Imágenesunclassified

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Tratamiento Quirúrgico de las Metástasis Hepáticas de Cáncer Colorectal. De las Resecciones Locales al Trasplante Hepático

et al. 2019

Rev. Cirugia

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El cáncer colorectal es de las principales causas de muerte por cáncer a nivel mundial. Una proporción importante de los casos desarrolla metástasis hepáticas. Gracias a los avances diagnósticos y tratamientos oncológicos, la sobrevida ha ido en aumento, sin embargo, para ello es fundamental lograr la resección quirúrgica completa de las lesiones primarias y metastásicas con márgenes microscópicos negativos (R0). Existen numerosos procedimientos y técnicas diseñadas para este objetivo como la quimioterapia neoadyuvante, embolización portal, cirugía en etapas, etc. A pesar de ello, hay casos no resecables por compromiso hepático bilobar, multisegmentario y/o compromiso de vasos arteriales, portales o venosos que en caso de resección, no permiten mantener hígado remanente funcional compatible con la vida del paciente. El trasplante hepático surge como alternativa radical para el tratamiento de casos no resecables. Dado la escasez de donantes y mortalidad en la lista de espera nacional, no es aceptable ocupar hígados del pool de donantes para patologías con criterios expandidos como metástasis colorectales. Sin embargo, con el recurso del donante vivo de adulto a adulto, hoy en día es posible indicar trasplante en casos seleccionados, que cumplan con todos los criterios establecidos.

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Section: Tratamiento Quirúrgico De Las Metástasis Hepáticas De Cáncerunclassified

Section: Definición Actual De Resecabilidadunclassified

Section: Estudio De Imágenesunclassified

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Tratamiento Quirúrgico de las Metástasis Hepáticas de Cáncer Colorectal. De las Resecciones Locales al Trasplante Hepático

et al. 2019

Rev. Cirugia

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Tumor‐derived endomucin promotes colorectal cancer proliferation and metastasis

Huang

Sun

et al. 2022

Cancer Medicine

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Background Endomucin (EMCN) is a type I transmembrane glycoprotein and a mucin‐like component of the endothelial cell glycocalyx. The mechanism of EMCN action in colorectal cancer (CRC) remains unclear. Aims Our aim was to explore the role of EMCN in the progression of CRC. Materials & Methods We examined EMCN expression in CRC tissues and normal para‐carcinoma tissues. The function and mechanisms of EMCN were checked in CRC cell lines and in mouse xenograft. Additionally, we used co‐immunoprecipitation and mass spectrometry to identify the potential EMCN‐binding proteins. Functional annotation analysis showed where these genes were enriched. Results We found that EMCN was overexpressed in tumor tissues compared with that in normal para‐carcinoma tissues. We also found that overexpression of EMCN induced CRC proliferation and metastasis both in vitro and in vivo. EMCN knockdown prevents epithelial‐mesenchymal transition in vitro. We identified 178 potential EMCN‐binding partners. Furthermore, functional annotation analysis indicated that these genes were considerably enriched in carcinogenic‐related functions and pathways. Collectively, the identification of EMCN‐binding partners enhanced our understanding of the mechanism of EMCN‐mediated malignant phenotypes, and this research may provide valuable insights into the molecular mechanisms underlying CRC. Conclusion Tumor‐derived endomucin promotes colorectal cancer proliferation and metastasis. We identified 178 EMCN‐binding proteins and initially screened three potential EMCN‐interacting proteins: NALCN, and TPM2, ANKK1. Our study provides valuable insights into the molecular mechanisms underlying CRC development.

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Prediction of liver and lung metastases in patients with early‐onset colorectal cancer by nomograms based on heterogeneous and homogenous risk factors

Sun,

Fan

et al. 2023

Cancer Medicine

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BackgroundIdentifying the risk factors for distant metastasis in early‐onset colorectal cancer (EOCRC) is crucial for elucidating its etiology and facilitating preventive treatment. This study aims to characterize the variability in EOCRC incidence and discern both heterogeneous and homogeneous risk factors associated with synchronous liver, lung, and hepato‐lung metastases.MethodsThis study included patients with EOCRC enrolled in the SEER database between 2010 and 2015 and divided patients into three groups by synchronous liver, lung, and hepato‐lung metastases. Each group of patients with different metastasis types was randomly assigned to the development and validation cohort in a ratio of 7:3. Logistic regression was used to analyze the heterogeneous and homogenous risk factors for synchronous liver, lung, and hepato‐lung metastases in the development cohort of patients. Nomograms were built to calculate the risk of metastasis, and the receiver operating characteristic (ROC) curve and calibration curve were used to quantitatively evaluate their performance.ResultsA total of 16,336 eligible patients with EOCRC were included in this study, of which 17.90% (2924/16,336) had distant metastases. The overall incidences of synchronous liver, lung, and hepato‐lung metastases were 11.90% (1921/16,146), 2.42% (390/16,126), and 1.50% (241/16,108), respectively. Positive CEA values before treatment, increased lymphatic metastases, and deeper invasion of intestinal wall were positively correlated with three distant types of metastases. On the contrary, the correlation of age, ethnicity, location of primary tumor, and histologic grade among the three types was inconsistent. The ROC curve and calibration curve proved to have fine performance in predicting distant metastases of EOCRC.ConclusionsThere are significant differences in the incidence of distant metastases in EOCRC, and related risk factors are heterogeneous and homogenous. Although limited risk factors were incorporated in this study, the established nomograms indicated good predictive performance.

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Historical perspective: Two decades of progress in treating metastatic colorectal cancer

Cited by 50 publications

References 173 publications

Tratamiento Quirúrgico de las Metástasis Hepáticas de Cáncer Colorectal. De las Resecciones Locales al Trasplante Hepático

Tratamiento Quirúrgico de las Metástasis Hepáticas de Cáncer Colorectal. De las Resecciones Locales al Trasplante Hepático

Tumor‐derived endomucin promotes colorectal cancer proliferation and metastasis

Prediction of liver and lung metastases in patients with early‐onset colorectal cancer by nomograms based on heterogeneous and homogenous risk factors

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